Clinical trials: Independence
Spinal Cord Injuries
Kayak Ergometer Training in Individuals With Spinal Cord Injury
One of the main objectives in spinal cord injury rehabilitation programs is the improvement of trunk control in order to achieve independence, to prevent complications and, in specific cases to walk.
- Trial name
- NCT03531164
- Testing
- kAYAK ERGOMETER GROUP, CONTROL GROUP
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Puberty, Precocious
Pediatrics Testotoxicosis Study [Bicalutamide Anastrozole Treatment for Testotoxicosis]
The primary objective of this study is to investigate whether bicalutamide given in combination with anastrozole once daily for 12 months is effective in treating testotoxicosis in boys.
- Trial name
- BATT (NCT00094328)
- Testing
- Bicalutamide, Anastrozole
- Where
- 15 sites in United States, Canada and 4 more
- Volunteers
- 14 people
- Sponsor
- AstraZeneca
Type 1 Diabetes
The Insulin Independence Trial (IIT) Evaluating the Safety and Efficacy of Oral Cyclosporine and Oral Lansoprazole for Insulin Independence Among Patients With Existing Type 1 Diabetes
The purpose of this study is to determine if oral Cyclosporine A and oral Lansoprazole are effective in rendering patients with existing type 1 diabetes, insulin independent.
- Trial name
- IIT (NCT01762657)
- Testing
- Oral Cyclosporine and Oral Lansoprazole
- Sponsor
- Perle Bioscience, Inc.
Rett Syndrome
Measuring Impact of Computer Gaming on Arm Use in Rett Syndrome
Using a tele-research approach, we will recruit, enroll, guide and support carers and participants to engage in computer based activities (modified virtual reality) with the primary outcome of reducing stereotypies and increasing…
- Trial name
- NCT05012475
- Testing
- Modified Virtual Reality Gaming
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Georgetown University
Lymphedema, Lymphatic Filariasis
A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-SL (NCT02929134)
- Testing
- Doxycycline
- Where
- Sri Lanka
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- The Task Force for Global Health
Staphylococcus Aureus Pneumonias
Panton Valentine Leucocidin
Staphylococcus aureus expresses a variety of virulence factors, including Panton Valentine leukocidin (PVL), a cytotoxin. PVL is specifically associated with primary skin and soft-tissue infections and severe necrotizing…
- Trial name
- PVL (NCT02798497)
- Testing
- Serum and Blood samples
- Where
- France
- Volunteers
- 234 people
- Sponsor
- Hospices Civils de Lyon
Program Engagement, Treatment Adherence and Compliance
Choice and Autonomy in Learning Mindfulness for Pediatric Residents
This study is a pilot clinical trial designed to evaluate a flexible, online mindfulness program for pediatric residents. Medical training can be stressful, and although mindfulness programs are often offered to support…
- Conditions
- Program Engagement, Treatment Adherence and Compliance, Mindfulness, Self-Compassion
- Trial name
- CALM-PR (NCT07542769)
- Testing
- Wakeful Digital Mindfulness Program
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Lung Cancer
BICR in New Therapeutic Lung Cancer Trials
Double reads in blinded independent central reviews (BICRs) are recommended to control the quality of trials but they are prone to discordances.
- Trial name
- NCT05038826
- Where
- France
- Volunteers
- 1,833 people
- Sponsor
- Median Technologies
Precocious Puberty, Gonadotropin-dependent
(Z)-Endoxifen in Girls With MAS-Associated Peripheral Precocious Puberty
The goal of this clinical trial is to evaluate the safety, tolerability, and blood levels of (Z)-endoxifen in girls with McCune-Albright Syndrome that have peripheral precocious puberty.
- Trial name
- NCT07869732
- Testing
- (Z)-endoxifen
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Atossa Therapeutics, Inc.
Adrenal Gland Neoplasm
Study of Adrenal Gland Tumors
The adrenal glands, located atop the kidneys, normally produce several types of hormones. Tumors of these glands may or may not secrete hormones.
- Trial name
- NCT00005927
- Where
- United States
- Volunteers
- 690 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Co-Occurring Disorders, Homelessness
Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking
This study seeks to implement wrap around services for Veterans suffering from co-occurring mental illness and substance use and who are homeless.
- Conditions
- Co-Occurring Disorders, Homelessness, Substance Abuse Disorder, Mental Illness
- Trial name
- MISSION-HPACT (NCT02942979)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- VA Office of Research and Development
Lymphedema, Lymphatic Filariasis
A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-Mali (NCT02927496)
- Testing
- Doxycycline
- Where
- Mali
- Volunteers
- 220 people
- Sponsor
- The Task Force for Global Health
Adverse Events
Retrospective Independent Safety Review of Closed Irrisept Study
The purpose of CLP-01 was to complete the safety endpoint of the closed trial and ensure that all safety data generated by IRR-CT-901-2013-01 was accounted for and accurately identified, verified, and independently adjudicated.
- Trial name
- NCT05359666
- Testing
- Irrisept, Standard of Care
- Where
- 17 sites in United States
- Volunteers
- 592 people
- Sponsor
- Irrimax Corporation
Knee Osteoarthritis
Implementing Group Physical Therapy (PT) for Veterans With Knee Osteoarthritis (Group PT): Function QUERI 2.0
Implementing Group Physical Therapy (PT) for Veterans with Knee Osteoarthritis (OA): Function QUERI 2.0 (Group PT) aims to implement, evaluate and sustain Group PT in 16 VA sites using a type III effectiveness-implementation…
- Trial name
- Group PT (NCT05282927)
- Testing
- Implementation Strategy: Foundational REP, Implementation Strategy: Enhanced REP (enREP)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Spinal Dysraphism
Assessment of Functional Independence and Quality of Life in Adolescents With Spina Bifid
The purpose of this study is to investigate the level of functional independence and the quality of life of adolescents and young adults with spina bifid in an Italian population.
- Trial name
- NCT00966927
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Pneumonia
Evaluation of Integrated Community Case Management in Ethiopia
The purpose of this study is to to measure the effect of the HEP+ICCM program relative to routine HEP approach in rural Ethiopia on changes in coverage of case management of common childhood illnesses and severe acute…
- Trial name
- NCT01606267
- Testing
- health systems intervention: HEP+ICCM
- Where
- Ethiopia
- Volunteers
- 607,770 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Pediatric Obesity, Nutrition Disorder
A Positive Food Parenting Intervention to Promote Healthy Growth in Children at Risk for Obesity
This study is the pilot of a 12 - week positive food parenting intervention focused on structure-based and autonomy promoting practices.
- Trial name
- NCT06981429
- Testing
- Nourish to Flourish: The Power of Positive Food Parenting
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Mobility Limitation, Physical Activity
PREPA PREvention of Loss of Autonomy
According to several reports, the proportion of people aged 80yrs or older will be doubled within the next 25y, reaching 10% of the global population.
- Trial name
- PREPA (NCT03667664)
- Testing
- Multidimensional assessments, Multicomponent group-based and supervised exercise program, Follow-up at T3 + 6 months and T3 + 12 months
- Where
- France
- Volunteers
- 530 people
- Sponsor
- Hospices Civils de Lyon
Activities of Daily Living, Hospitalization
Independence in Self Care - A Program Focused on Nursing Care
This study is a randomized clinical trial conducted in a medical ward of an acute 580-bedded teaching hospital. One hundred fifty-eight older acute medical patients will be blindly randomly allocated to the control group or…
- Conditions
- Activities of Daily Living, Hospitalization, Nursing Care, Functional Impairment
- Trial name
- NCT03106064
- Testing
- Promoting independence in self-care, Usual Care
- Where
- Portugal
- Volunteers
- 158 people
- Sponsor
- Centro Hospitalar do Porto