Clinical trials: Infant Development
Twins, Preterm Infants
Internal and Familial Resources and Motherhood. Follow Up of Mothers With Twins and Preterm Infants Versus Mothers With Single Full Term Infants
To evaluate the contribution of internal and familial resources on the development of motherhood in a population of mothers having preterm twin infants and comparing this population to a population of mothers giving birth to…
- Trial name
- NCT00320840
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Astigmatism Bilateral, Eyeglasses
Spectacle Prescribing in Early Childhood
The purpose of this study is to compare developmental outcome for young children (12 to 35 months of age) with astigmatism meeting American Academy of Ophthalmology spectacle prescribing guidelines and who are prescribed and…
- Trial name
- SPEC (NCT04728451)
- Testing
- Spectacle wear support, Spectacles
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Pregnancy Related, Pregnancy Disease
Chinese Pregnant Woman Cohort Study (Offspring Follow-up)
Purpose: To investigate the growth and development status for children of 1 ~ 3 years old in China, and to explore and analyze the influencing factors of infant growth.
- Conditions
- Pregnancy Related, Pregnancy Disease, Pregnancy, Infant Development
- Trial name
- NCT04444791
- Where
- China
- Volunteers
- 1,978 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Immune System Disorder, Preterm
Preterm Immune System Development and Response to Immunization
In this study the response to vaccination and development of the immune system in very preterm infants upon the current vaccination schedule will be compared to healthy term infants.
- Conditions
- Immune System Disorder, Preterm, Vaccination Failure
- Trial name
- PRIMI (NCT05266664)
- Where
- 7 sites in Netherlands
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Preterm Birth, Breast Milk Expression
Targeting Human Milk Fortification to Improve Preterm Infant Growth and Brain Development
This study is a randomized trial comparing 2 methods of human milk fortification for preterm infants in the neonatal intensive care unit (NICU).
- Conditions
- Preterm Birth, Breast Milk Expression, Nutrition Disorder, Infant, Brain Development Abnormality
- Trial name
- NCT03977259
- Testing
- Individually targeted fortification
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Brigham and Women's Hospital
Autism Sibling
Sibwatch: Optimizing Intervention Options for Infants and Toddler Siblings of Autistic Children
This rigorous randomized controlled trial will evaluate the efficacy and acceptability of a preemptive, telehealth intervention (tele-ImPACT) in a large, representative sample of infant siblings of autistic children, who are…
- Trial name
- Sibwatch (NCT07069413)
- Testing
- tele-ImPACT
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Texas at Austin
Child Development
Zambia Infant Cohort Study - Brains Optimized for Surviving and Thriving
Children exposed to HIV in-utero but uninfected (CHEUs) number 14.8 million globally. In Zambia, an estimated 56,000 CHEUs are born annually, a staggering fraction of the national birth cohort.
- Trial name
- ZICS-BOOST (NCT05119959)
- Testing
- ECD intervention for CHEUs, Usual care for CHEUs
- Where
- 2 sites in United States, Zambia
- Volunteers
- 469 people
- Sponsor
- Boston University
Infant Development
Effect of Long-Chain Polyunsaturated Fatty Acid Supplementation on Toddler Cognition
The hypothesis to be examined is that dietary LCP-supplementation in the second and third years of life will improve cognitive and visual maturation in early childhood.
- Trial name
- NCT00982462
- Testing
- Docosahexaenoic acid (DHA) and arachidonic acid (ARA)
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Retina Foundation of the Southwest
Cerebral Palsy Infantile, Pre-Term
Motor-voice Assessment in Infants (MAMI)
The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants..
- Conditions
- Cerebral Palsy Infantile, Pre-Term, Motor Delay, Neurodevelopmental Disorders
- Trial name
- MAMI (NCT06807203)
- Testing
- Behavioral observation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Ohio State University
Preterm Birth, Parent-Child Relations
Epigenetics and Protective Factors in the Preterm Infant
Preterm infants (PT) spend their first weeks of life in the Neonatal Intensive Care Unit (NICU) where they are exposed to unfavorable conditions with different effects on child development including long-term alterations in…
- Conditions
- Preterm Birth, Parent-Child Relations, Epigenetics
- Trial name
- EPIC (NCT04804280)
- Testing
- DNA methylation of target genes, Functional Magnetic Resonance Imaging (fMRI) acquisition
- Where
- Italy
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Pneumonia, Pollution; Exposure
The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa
This study will evaluate the feasibility and acceptability of a household-based clean air intervention
- Conditions
- Pneumonia, Pollution; Exposure, Lung Function Decreased, Chronic Respiratory Disease
- Trial name
- PLUS2 (NCT05724082)
- Testing
- Clean Air Intervention
- Where
- Uganda
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Infant Development, Cerebral Palsy
Families Filming Infants Learning Movement
The study objective is to improve accuracy in the early detection of neurodevelopmental impairment, especially CP, by evaluating the timepoint (in weeks post term age) that the Prechtl GMA is most useful for prediction of…
- Conditions
- Infant Development, Cerebral Palsy, Motor Disorders, Neurological Disorder
- Trial name
- FILM (NCT06278961)
- Testing
- Observational
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Psychomotor Development Impaired
Psychomotor Performance of Preterm Infants
The first part involved 120 children in grades II and III of elementary schools. From this group, children were qualified for the second part of the study - 35 randomly selected children born on time (BoT) and 35 children born…
- Trial name
- NCT05930522
- Where
- Poland
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Premature Birth
Permissive Hypercapnia and Brain Development in Premature Infants
In the US, every year approximately 30,000 infants are born very prematurely, with birth weight less than 1000 grams. These infants usually require ventilators to help them breath normally during the first few weeks of life.
- Trial name
- NCT01361360
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Breastfeeding, Infant Development
Effectiveness of an Early Nutrition Program on Promoting Breastfeeding and Optimizing Infant Growth and Diet Quality
Effective early life programs that reduce the long-term non-communicable diseases (NCDs) risk could bring great economic benefits to the society.
- Trial name
- NCT03493594
- Testing
- Nutrition education program
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Neurodevelopmental Abnormality
Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU)
A sub-study to evaluate longer-term developmental outcomes in non-vigorous term and near-term newborns who receive umbilical cord milking in comparison to those who undergo early cord clamping at delivery.
- Trial name
- MINVIFU (NCT03621943)
- Testing
- Umbilical Cord Milking, Early Cord Clamping
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 1,207 people
- Sponsor
- Sharp HealthCare
Literacy, Parent-Child Relations
Testing an App-Based Approach to Reading and Screen Time Guidance for Parents of Infants
The American Academy of Pediatrics (AAP) recommends that parents read to their children as often as possible beginning in infancy and limits on screen time at all ages, yet many families question the value of reading to infants…
- Conditions
- Literacy, Parent-Child Relations, Language Development
- Trial name
- NCT05508282
- Testing
- Reading Bees app and children's book to enhance parent-infant reading quality (0-2 month visit), Reading Bees app and children's book to encourage alternatives to digital media (6-month visit)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Premature - Weight 1000g-2499g or Gestation of 28-37weeks, Premature Baby 26 to 32 Weeks
Comparison of Two Early Treatments for Premature Babies and Their Effects Over Time
According to the latest World Health Organization report, prematurity is a major health issue, recognized as a significant vulnerability factor contributing to the emergence of neurodevelopmental disorders.
- Conditions
- Premature - Weight 1000g-2499g or Gestation of 28-37weeks, Premature Baby 26 to 32 Weeks, Premature Baby 33 to 36 Weeks, Premature Between 32 and 36 Weeks of Amenorrhoea
- Trial name
- PREMOTSENS (NCT07261046)
- Testing
- ATVV (Auditory, Tactile, Visual and Vestibular stimulation), Singing
- Where
- 2 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Elsan
Premature Birth of Newborn
Neuroendocrine Mechanisms of Developmental Massage Therapy (DMT) in Preterm Infants: Clinical Study
The purpose of this study is to see if daily massage therapy will help premature infants respond to stress better, as well as improve their growth and neurobehavioral development.
- Trial name
- DMT (NCT00722943)
- Testing
- Developmental Massage Therapy, no intervention
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of Utah