Clinical trials: Infant Gut Microbiome
Gut Microbiota, Skin Microbiota
Lactobacillus Rhamnosus GG: Interaction With Human Microbiota and Immunity
Hypothesis: Probiotics have been used as novel adjunct therapeutic approach in atopic dermatitis. In addition to balancing the gut microecology and promoting host immune defences, specific probiotics might further aid in…
- Conditions
- Gut Microbiota, Skin Microbiota, Humoral Immune Responses, Severity of Atopic Dermatitis
- Trial name
- NCT01148667
- Testing
- Casein hydrolysate added with LGG, Infants drink casein hydrolysate without LGG
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Anemia, Iron Deficiency
Iron and Prebiotics Fortification in Kenyan Infants
Iron deficiency and anemia are health issues affecting mainly infants and women in developing countries. Iron deficiency in infancy can have long-lasting impact on cognitive and motor development of the child.
- Conditions
- Anemia, Iron Deficiency, Diarrhea, Malaria
- Trial name
- Iro'n'Pre (NCT02118402)
- Testing
- Fortified maize porridge
- Where
- Kenya
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Infant Growth and Development, Gut Microbiota
The Impact of Early-life Organic Feeding on Infants' Health: A Cluster Randomized Controlled Trial
This completed study compared early-life feeding with organic infant formula and organic complementary foods, conventional infant formula and conventional complementary foods, and breastfeeding with family-selected complementary…
- Trial name
- NCT07886424
- Testing
- Organic infant formula and organic complementary foods, Conventional infant formula and conventional complementary foods
- Where
- 3 sites in China
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Gut Microbiota
Impact of Probiotics Supplement on the Gut Microbiota in Caesarean-born Infants
The purpose of this study is to evaluate the effect of probiotics on the gut microbiota of infants born by cesarean section.
- Trial name
- NCT05086458
- Testing
- probiotics
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Obesity, Metabolic Syndrome
Milk Types and Fish Oil in 9- to 12-Month-Old Infants
The objective of this intervention study is to examine the effect of whole cow's milk versus infant formula as primary milk sources with or without supplements of n-3 LCPUFA for growth, nutritional status, development, risk…
- Conditions
- Obesity, Metabolic Syndrome, Growth, Blood Pressure
- Trial name
- NCT00379171
- Testing
- Cow's milk with fish oil, Cow's milk without fish oil, Formula with fish oil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Infant Allergy, Infant Gut Health
Study on the Impact of Different Feeding Methods on Allergy Prevention and Digestive Absorption in Infants and Young Children
Based on a real-world research paradigm, this study aims to evaluate the performance of infants fed via different methods-specifically goat milk formula, control formula, and breastfeeding-regarding allergy prevention and protein…
- Conditions
- Infant Allergy, Infant Gut Health, Infant Respiratory Diseases, Infant Feeding Scale
- Trial name
- NCT07886437
- Testing
- Observation, biological sample collection: stool
- Where
- China
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Child Growth, Diversity of Microbiome
MORDOR II Burkina Faso: Longitudinal Trial
Globally, childhood mortality has shown a promising downward trend in recent years, however, many sub-Saharan countries still have relatively high child mortality rates.
- Conditions
- Child Growth, Diversity of Microbiome, Child Mortality, Resistance Bacterial
- Trial name
- GAMIN (NCT03676751)
- Testing
- Azithromycin
- Where
- Burkina Faso
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Jaundice, Neonatal
Research of Diagnostic Value for BMJ Infants
Breast milk jaundice (BMJ) is the main cause of neonatal hyperbilirubinemia. Excessive serum unconjugated bilirubin level will not only cause the interruption or early termination of breastfeeding, but also cause kernicterus.
- Trial name
- NCT04527536
- Testing
- Neonatal hyperbilirubinemia
- Volunteers
- 300 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Cow Milk Allergy
A Growth and Hypoallergenicity Study of a New Formula for Infants With Cow Milk Allergy
This study involves the use of 2 different Neocate formulas: a control formula called Neocate Infant and a test Neocate formula.
- Trial name
- CMA (NCT00664768)
- Testing
- Neocate Infant, new Neocate
- Where
- 22 sites in United States
- Volunteers
- 126 people
- Sponsor
- Nutricia North America
Healthy Newborn Infants
Resilience to Antibiotic-induced Obesogenic Microbiota: Discovering Mechanism of Microbiota Modulation
The aim is to study whether the microbiota of children who are exposed to antibiotics at birth could be modified by synbiotic supplement and thereby reduce the risk of obesity, chronic diseases and respiratory tract infections.
- Trial name
- ReCoverHealth (NCT06974994)
- Testing
- Synbiotic Supplement
- Where
- Finland
- Volunteers
- 125 people
- Sponsor
- Turku University Hospital
Respiratory Syncytial Virus Infection, Bronchiolitis
Gut Microbiome and Immune Response in Severe RSV Infection in Vietnamese Infants
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in young children, and a substantial proportion of severe cases occur in previously healthy infants.
- Conditions
- Respiratory Syncytial Virus Infection, Bronchiolitis, Viral Lower Respiratory Tract Infection (LRTI)
- Trial name
- GUT-LUNG RSV (NCT07417657)
- Where
- Vietnam
- Volunteers
- 250 people
- Sponsor
- Phuc Huu Phan
Focus on Healthy Infant Growth.
Infant Formula Supplemented With Probiotic Microorganisms and/or Prebiotic.
Evaluation the nutritional suitability of a based milk infant formula supplemented with friendly bacteria (probiotic microorganisms) and or nutritional fibers (prebiotic) to healthy, full term infants compare with an otherwise…
- Trial name
- NCT00836771
- Testing
- Infant Formula
- Where
- Israel
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Materna Laboratories
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Low Birth Weight Infants
The Influence by Dietary Human Milk Oligosaccharide in Low Birth Weight Infants
This study aims to investigate the concentration of various growth factors and cytokines in blood, and to examine the gut microbiota of low birth weight infants fed with formulas with or without Human Milk Oligosaccharide (HMO)…
- Trial name
- NCT05203900
- Testing
- Infant formula with Human Milk Oligosaccharide, Infant formula without Human Milk Oligosaccharide
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Meiji Co., Ltd.
Urinary Tract Infections
The Association of Gut Microbiota With Urinary Tract Infection in Infants
This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants.
- Trial name
- NCT04615689
- Testing
- The collection of feces
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Preterm, Neurodevelopmental Disorders
Dietary Pattern Intervention for Neurodevelopment in Preterm Infants
The purpose of this randomized controlled trial is to evaluate the effect of a structured, high-prebiotic dietary pattern on the neurodevelopmental outcomes of preterm infants.
- Conditions
- Preterm, Neurodevelopmental Disorders, Dysbiosis
- Trial name
- NCT07702734
- Testing
- Structured High-Prebiotic Dietary Pattern
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Fudan University
Gastrointestinal Complication, Intestinal Obstruction
The Influence of Feeding Source on the Gut Microbiome and Time to Full Feeds in Neonates With Congenital Gastrointestinal Pathologies
This study explores the use of an exclusive human milk diet versus standard feeding practices to compare the influence on feeding outcomes and the gut bacteria in infants with intestinal differences.
- Conditions
- Gastrointestinal Complication, Intestinal Obstruction, Gastroschisis, Hirschsprung Disease
- Trial name
- NCT06072976
- Testing
- Standard of Care, Exclusive Human Milk
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Seattle Children's Hospital
Breast Milk Collection, Human Milk/Breastfeeding
Human Milk and Its Effect on Infant's Metabolism and Infant Gut Microbiome
This protocol explains the MAINHEALTH cohort. The study examine the influence of maternal health parameters on human breast milk composition and integrates milk phenotype with infant metabolism and infant gut microbial content…
- Conditions
- Breast Milk Collection, Human Milk/Breastfeeding, Human Milk Microbiome, Infant Gut Microbiome
- Trial name
- MAINHEALTH (NCT05111990)
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cystic Fibrosis
Intestine-lung Axis of Cystic Fibrosis Patients Treated With the Combination Elexacaftor/Tezacaftor/Ivacaftor
Cystic fibrosis is a systemic disease, which affects in particular the respiratory and digestive systems of patients, sites of chronic inflammation.
- Trial name
- KAF-BIOTA (NCT05937815)
- Testing
- Sample collection
- Where
- 15 sites in France
- Volunteers
- 253 people
- Sponsor
- University Hospital, Bordeaux
Microbiota, Eczema
Intestinal Microbiota Composition After Antibiotic Treatment in Early Life
In this prospective observational cohort study the potential clinical consequences of antibiotic use in early life and perturbations in the gastrointestinal microbiota composition due to that antibiotic use are studied.
- Conditions
- Microbiota, Eczema, Atopy
- Trial name
- INCA (NCT02536560)
- Where
- 4 sites in Netherlands
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Agentschap NL