Clinical trials: Infantile Diarrhea
Diarrhea, Infantile
Descriptive Study of Pathogens Involved in Summer Diarrhea in Children Leading to Pediatric Emergency Room Visits (PE-DIA)
Acute diarrhea in children is a public health problem. It is estimated that children under 3 years are subject to 1 or 2 episodes of diarrhea per year in Europe.
- Trial name
- PE-DIA (NCT04209751)
- Testing
- Stool removal
- Where
- France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infantile Colics, Constipation
Randomized, Blinded, Placebo-Controlled Evaluation of BioAmicus Complete
This is a randomized, single-blind, placebo-controlled study to evaluate the efficacy of the dietary supplement BioAmicus Complete (oral drops; a mixture of 10 strains of lacto- and bifidobacteria) in managing functional…
- Conditions
- Infantile Colics, Constipation, Infantile Diarrhea, Atopic Dermatitis
- Trial name
- NCT07444008
- Testing
- BioAmicus Complete
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- NovoNatum Ltd
Diarrhea, Infantile, Enteropathy
Whole Genome Sequencing Versus Whole Exome Sequencing for Congenital Diarrhea and Enteropahty
This study will seek to determine if whole genome sequencing (WGS) improves diagnostic rates, and outcomes for congenital diarrhea and enteropathy (CODE) patients.
- Trial name
- NCT04528303
- Testing
- Whole genome sequencing, Whole exome sequencing
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Children's Hospital of Fudan University
Acute Gastroenteritis
Fortified Oral Rehydration Therapy for Pediatric Diarrhea
The goal of this clinical trial is to compare amino acid-fortified oral rehydration therapy (ORT) to the standard of care ORT in pediatric patients with acute gastroenteritis (AGE).
- Trial name
- fORT (NCT06137014)
- Testing
- Fortified Oral Rehydration Therapy, Standard of Care Oral Rehydration Therapy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Paul A Breslin
Diarrhea, Infantile
Study on the Association Between Vitamin C Deficiency and Diarrhea in Children
Diarrheal disease is the second leading cause of death in children under five, althought it is both preventable and treatable. The causative factors of diarrheal diseases vary a lot from region to region (bacteria, viruses…
- Trial name
- VITAL (NCT05328037)
- Testing
- Blood sample collection
- Where
- 3 sites in Central African Republic, France and 1 more
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Infantile Colic, Gastroesophageal Reflux (GER)
BioAmicus Complete for Functional Gastrointestinal Symptoms in Infants Aged 0 to 24 Months
Infants often experience functional gastrointestinal symptoms (e.g., colic, excessive gas, regurgitation, constipation, or loose stools) that distress families and may reflect an imbalance of the gut microbiome.
- Conditions
- Infantile Colic, Gastroesophageal Reflux (GER), Functional Constipation, Functional Diarrhea
- Trial name
- CTBE2503 (NCT07148583)
- Testing
- BioAmicus Complete, Usual Care (No Probiotic)
- Where
- Vietnam
- Volunteers
- 110 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
Diarrhea Infantile
Phenotype and Multi-omics Analysis of Children With Congenital Diarrhea and Enteropathy in China
This study will establish a clinical cohort of children with congenital diarrhea and enteropathy (CODE), mine biomarkers of CODE through multi-omics technology and construct a clinical risk prediction model.
- Trial name
- NCT06356545
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Diarrhoea;Infectious;Presumed, Diarrhea, Infantile
Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa
This project is a community-based randomized controlled trial designed to test the effectiveness of two point-of-use water treatment technologies to improve clean drinking water access, reduce enteropathogen burden, and improve…
- Conditions
- Diarrhoea;Infectious;Presumed, Diarrhea, Infantile, Diarrhea Tropical, Environmental Exposure
- Trial name
- NCT03012048
- Testing
- Silver-impregnated ceramic tablet, Silver-impregnated ceramic water filter, Safe-storage water container
- Where
- South Africa
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Rotavirus Gastroenteritis, Rotavirus Vaccines
ROTA-biotic: Measuring the Impact of Rotavirus Vaccines on Paediatric Antibiotic Usage
Rotavirus is the most common aetiology of serious diarrhoea in young children. Despite antibiotics not being indicated in its treatment, diarrhoea remains a very common cause for antibiotic prescribing in low-income settings.
- Conditions
- Rotavirus Gastroenteritis, Rotavirus Vaccines, Antimicrobial Resistance (AMR), Antibiotic
- Trial name
- NCT06882070
- Testing
- Vaccine
- Where
- 2 sites in Ghana, Zambia
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Functional Gastrointestinal Disorders, Gastroesophageal Reflux
Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants.
The goal of this observational study is to learn about the prevalence and characteristics of functional gastrointestinal disorders (FGID) in at risk infants (former preterm infants and those with birth asphyxia) during the first…
- Conditions
- Functional Gastrointestinal Disorders, Gastroesophageal Reflux, Constipation - Functional, Diarrhea
- Trial name
- FUSID (NCT06031025)
- Testing
- Questionnaire, clinical examination
- Where
- Italy
- Volunteers
- 71 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stool Assessment, Skin Rash
GI Symptoms in Infants Fed Goat Milk-based Infant Formula
A cross-sectional observational survey was conducted in Brazil, Mexico, Russia, and The Netherlands by recruiting parents/legal guardians through social media.
- Conditions
- Stool Assessment, Skin Rash, Urticaria, Regurgitation
- Trial name
- NCT06755424
- Where
- Netherlands
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Ausnutria Hyproca B.V.
Diarrhea, Infantile, Infection Gastrointestinal
PAthogen Transmission and Health Outcome Models of Enteric Disease
The objective of the PATHOME study is to (1) develop statistical and computational methods for examining a complex disease system of interactions between and amongst children, animals, the environment, and enteric pathogens and…
- Conditions
- Diarrhea, Infantile, Infection Gastrointestinal, Stunting, Wasting
- Trial name
- PATHOME (NCT05322655)
- Where
- Kenya
- Volunteers
- 286 people
- Sponsor
- State University of New York at Buffalo
Diarrhea, Infantile
Study to Evaluate the Efficacy and Safety of Racecadotril in Children Aged 3 to 60 Months Suffering From Acute Diarrhea
This is a prospective, open-label, multicenter, single-arm study evaluating the efficacy and safety of Racecadotril the treatment of children aged 3 to 60 months suffering from acute diarrhea
- Trial name
- NCT03473561
- Testing
- Racecadotril plus ORS
- Where
- 2 sites in Taiwan
- Volunteers
- 31 people
- Sponsor
- Abbott
Infantile Colic, Constipation
Randomized Placebo-controlled Study of L. Reuteri NCIMB 30351 in GI Functional Disorders and Food Allergy in Newborns
This study is a randomized, placebo-controlled, single-masked (blinded), post-marketing clinical study of a drug Lactobacillus Reuteri NCIMB 30351 drops in functional disorders of gastrointestinal tract and skin symptoms of food…
- Conditions
- Infantile Colic, Constipation, Infantile Diarrhea, Gastro Esophageal Reflux
- Trial name
- NCT04262648
- Testing
- Lactobacillus Reuteri
- Where
- 2 sites in Russia
- Volunteers
- 90 people
- Sponsor
- NovoNatum Ltd
Diarrhea, Infantile
Effect of Prompting the Supply of Zinc/LO-ORS Co-packs in the Private Sector Plus BCI on Childhood Diarrhea Treatment
This study assesses whether prompting the supply of zinc and LO-ORS co-packs in the private sector coupled with behavior change communication (BCC) has an effect on the treatment of uncomplicated childhood diarrhea.
- Trial name
- NCT04335877
- Testing
- Private sector component + modified BCC
- Where
- Kenya
- Volunteers
- 1,245 people
- Sponsor
- Nutrition International
Diarrhea, Infantile
Efficacy and Safety of "VS002A" With the Standard WHO-ORS in Non-cholera Acute Watery Diarrhea in Infants and Young Children
Randomized double blinded clinical trial comparing amino acid based oral rehydration solution/medical food and glucose-based oral rehydration solution is infectious diarrhea in pediatric population
- Trial name
- NCT04677296
- Testing
- VS002A, WHO-ORS
- Where
- Bangladesh
- Volunteers
- 312 people
- Sponsor
- Entrinsic Bioscience Inc.
Death, Death, Infant
Coupons for Safe Water Project
Guaranteeing access to safe drinking water is still a challenge in rural households in developing countries, and unsafe water sources are responsible for millions of deaths each year around the world.
- Conditions
- Death, Death, Infant, Diarrhea, Diarrhea, Infantile
- Trial name
- Coupons (NCT05766826)
- Testing
- Coupons for safe water program: Treatment, Coupons for safe water program: Control
- Where
- 2 sites in Kenya
- Volunteers
- 3,468 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Nosocomial Infection, Diarrhea, Infantile
Effect and Tolerability of Lactobacillus Rhamnosus GG LA801 for the Preventive Nutritional Care of Nosocomial Diarrhea in Children
One of the most common infections acquired in hospital, also known as nosocomial infections, is intestinal infections. These infections can lead to the development of nosocomial diarrhea which can have serious consequences in…
- Trial name
- EPISODE (NCT04628819)
- Where
- 2 sites in France
- Volunteers
- 61 people
- Sponsor
- PiLeJe
Diarrhea, Infantile
IVC Index in Patient With Diarrhea and Dehydration And How It Affects Its Management
IVC Index in patient with Diarrhea and Dehydration And How It affects its management.
- Trial name
- NCT04654832
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diarrhoea;Acute, Diarrhea, Infantile
Efficiency and Safety of Zinc Sulphate to Reduce the Duration of Acute Diarrheal Disease Between 6 and 59 Months of Age
This study evaluates the effect of zinc over the duration, severity and relapse of acute diarrheic disease, in children between 6 and 59 months of age.
- Trial name
- ESZnDiarrhea (NCT04061538)
- Testing
- zinc sulfate
- Where
- 9 sites in Mexico
- Volunteers
- 529 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico