Clinical trials: Infection Complication
Vaginal Flora
Longitudinal Study of Vaginal Flora
Bacterial vaginosis is a syndrome manifested by adverse alterations in vaginal microbial flora. It is present in 10 to 25% of women in the general population, and is the most common vaginal infection.
- Trial name
- NCT00340275
- Where
- United States
- Volunteers
- 5,500 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Neonatal Infection, Invasive Fungal Infections
Micafungin Versus Amphotercine B in Treatment of Invasive Fungal Infection
The incidence of fungal infection has increased dramatically over the past few decades.This is due to increase in survival rates of preterm neonates, advances in medical technology and drug therapy, broad spectrum antibiotics and…
- Trial name
- NCT06413056
- Testing
- Micafungin, Amphotericin B
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Ain Shams University
Pelvic Inflammatory Disease
The Role of Novel Organisms in Acute Endometritis
The goal of this project is to identify the microorganisms present in the endometrial samples obtained from women with or without evidence of endometritis using a combination of culture methods, rRNA sequencing and whole genomic…
- Trial name
- NCT01236131
- Testing
- no intervention
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- Sharon Hillier
Infections, Papillomavirus
Immunogenicity and Safety of GlaxoSmithKline Biologicals' Huma Papillomavirus (HPV) Vaccine 580299 in Healthy Females 15 - 25 Years of Age
Infection with human papillomavirus (HPV) has been clearly established as the central cause of cervical cancer. The current phase 3b study is designed to assess the immunogenicity and safety of GlaxoSmithKline Biologicals' HPV…
- Trial name
- NCT00552279
- Testing
- Cervarix TM
- Where
- 16 sites in Italy, Romania and 1 more
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Brain and Central Nervous System Tumors, Breast Cancer
Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma
RATIONALE: Giving antibiotics may be effective in preventing or controlling early infection in patients receiving chemotherapy for solid tumors or lymphoma.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Extragonadal Germ Cell Tumor, Infection
- Trial name
- NCT00005590
- Testing
- levofloxacin
- Where
- United Kingdom
- Sponsor
- Cancer Research Campaign Clinical Trials Centre
Rhinosinusitis, Intracranial Extension
Role of Imaging in Complications of Sinusitis
This study aims to assess the diagnostic performance of CT and MRI in the diagnosis of complications of rhinosinusitis in comparison to clinical and operative findings.
- Conditions
- Rhinosinusitis, Intracranial Extension, Rhinosinusitis Chronic, Rhinosinusitis Acute
- Trial name
- NCT05836935
- Testing
- Multislice CT scan of the paranasal sinuses., MRI examination of the paranasal sinuses
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
HIV Infections
A Study of Amprenavir in Patients With Protease Inhibitor-Related Complications
The purpose of this study is to see if it is safe and effective to give the protease inhibitor (PI) amprenavir (APV) to patients with fat production and distribution problems associated with other PIs.
- Trial name
- NCT00002417
- Testing
- Amprenavir
- Where
- United States
- Sponsor
- Glaxo Wellcome
Cervical Cancer Squamous Cell, Human Papilloma Virus Infection
Hybrid Capture Test on Mobile Unit Program to Improve Cervical Cancer Screening in Brazilian Rural and Remote Areas
This study evaluates the women cervical samples through molecular tests in order to: 1. Deploy the test careHPV (hybrid capture test) in mobile unities of the Barretos Cancer Hospital to evaluate their performance;
- Conditions
- Cervical Cancer Squamous Cell, Human Papilloma Virus Infection, Human Papilloma Virus-Related Carcinoma, Prevention
- Trial name
- careHPV (NCT01539668)
- Where
- 2 sites in Brazil
- Volunteers
- 5,079 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
HPV Infections, Cervical Cancer
Immunobridging Study of 9-valent Human Papillomavirus Recombinant Vaccine in Chinese Females Aged 9 to 19 Years
This phase 3 study will evaluate the immunogenicity and safety of 9-valent HPV recombinant vaccine in Chinese females aged 9 to 45 years
- Conditions
- HPV Infections, Cervical Cancer, Vulvar Cancer, Vaginal Cancer
- Trial name
- NCT04895020
- Testing
- 9-valent HPV vaccine
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Upper Respiratory Tract Infections, Urinary Tract Infections
Routine Prescription Feedback and Peer Comparison to Lower Antibiotic Prescriptions in Primary Care
To evaluate the effect of a continuous postal and web-based feedback and peer comparison system of individual antibiotic prescription rates on the prescription behaviour of primary care physicians in Switzerland.
- Trial name
- NCT01773824
- Testing
- Antibiotic prescription feedback, No Feedback
- Where
- Switzerland
- Volunteers
- 2,900 people
- Sponsor
- University Hospital, Basel, Switzerland
Surgical Site Infection
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI.
- Trial name
- OPerAtiC (NCT04366440)
- Testing
- Order set review and modification with facilitation, Order set review and modification
- Where
- 10 sites in United States
- Volunteers
- 18,267 people
- Sponsor
- Washington University School of Medicine
Urinary Tract Infection, Vesicoureteral Reflux
Contrast Enhanced Ultrasound for Evaluation of Reflux Nephropathy
The study will be evaluating the efficacy and safety of a contrast drug in pediatric renal ultrasound.
- Trial name
- NCT02786810
- Testing
- Sulfur hexafluoride type-a lipid microspheres
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Necrotizing Enterocolitis, Sepsis
Lactulose Supplementation in Premature Infants
A pilot study to test the safety of use of lactulose in preterm infants and to preliminary assess the hypothesis that lactulose would support the early growth of Lactobacilli in the stools of premature infants and possibly would…
- Trial name
- NCT00616876
- Testing
- Lactulose, Dextrose
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Bnai Zion Medical Center
Efficacy Povidone Soaked Suture in Reducing Surgical Site Infection
Title: Povidone-soaked Sutures Versus Ordinary Sutures for Reducing Surgical Site Infection
To determine efficacy of using 3 minutes povidone-soaked suture in reducing surgical site infection during wound closure in elective surgery.
- Trial name
- NCT05090176
- Testing
- povidone-soaked suture, ordinary suture
- Where
- Malaysia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Surgical Site Infection in Obese Women Undergoing C-section
Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery
The purpose of this study is to evaluate if preoperative antibiotics, followed by 48 hour course of broad spectrum antibiotics prevents wound infection complications in patients that are obese who undergo cesarean section.
- Trial name
- SSI (NCT01194115)
- Testing
- cephalexin & metronidazole
- Where
- United States
- Volunteers
- 475 people
- Sponsor
- University of Cincinnati
Bacterial Vaginosis
Urogenital Infections in Women of Reproductive Age and the Activity of 4-Thiazolidinone Derivatives Against Pathogens
Research concerning women pathogenic microflora during different conditions
- Trial name
- NCT06616168
- Testing
- Microbiological identification kits (ANAEROtest, STAPHYtest, ENTEROtest, NEFERMtest), Antibiotic therapy after the results of antibiotic sensitivity test (Mostly Oxacillin, Benzylpenicillin, Ceftriaxone, Doxycycline, Clindamycin), Suppositoria for vaginal microflora recovery (Giynoflor)
- Where
- Ukraine
- Volunteers
- 200 people
- Sponsor
- Danylo Halytsky Lviv National Medical University
Incisional Hernia, Surgical Site Infection
Prophylactic Mesh Reinforcement for Stoma Closure
In the current work we are aiming to compare between the mesh-reinforced stoma closure and the anatomical closure in terms of the risk of developing surgical site incisional hernia (SSIH),incidence of surgical site infection …
- Conditions
- Incisional Hernia, Surgical Site Infection, Postoperative Pain, Hospital Stay, Length of Stay in Hospital From Surgery to Discharge
- Trial name
- OASIS (NCT06157645)
- Testing
- Prolene mesh
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Assiut University
Cryptococcosis
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or…
- Trial name
- NCT00001701
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute (NCI)
Surgery, Nasal Disease
Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections
This is a randomised, unblinded interventional device proof of concept pilot trial in which patients undergoing nasal surgery will be selected for either photodisinfection therapy (PDT) with the Steriwave™ ND System, or control…
- Conditions
- Surgery, Nasal Disease, Light; Therapy, Complications
- Trial name
- LIGHT (NCT06731881)
- Testing
- Nasal PDT, Photosensitizer formulation only, Standard follow-up
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Leukemias of Ambiguous Lineage, Bacterial Infection
Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation
This randomized phase III trial studies how well levofloxacin works in preventing infection in young patients with acute leukemia receiving chemotherapy or undergoing stem cell transplant.
- Conditions
- Acute Leukemias of Ambiguous Lineage, Bacterial Infection, Diarrhea, Fungal Infection
- Trial name
- NCT01371656
- Testing
- levofloxacin
- Where
- 84 sites in United States, Canada
- Volunteers
- 624 people
- Sponsor
- Children's Oncology Group
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