Clinical trials: Infection Control
Failure of Dental Implant Due to Infection, Infection
Regenerative Surgical Treatment of Peri-implantitis
The purpose of the study is to evaluate if surgical treatment of peri-implantitis with enamel matrix derivative (Emdogain®, EMD) will have an additional effect on the healing outcome, changes in the peri-implant microflora and on…
- Conditions
- Failure of Dental Implant Due to Infection, Infection, Inflammation, Peri-implantitis
- Trial name
- NCT02500654
- Testing
- Emdogain®, Surgery alone
- Where
- Sweden
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Catrine Isehed
Infections, Rotavirus
A Study to Test 2 Doses of the HRV Vaccine in Healthy Infants.
The main objectives of this study are: 1) In a subset (N = 20 000), to determine vaccine efficacy against severe rotavirus (RV) gastroenteritis (GE) during the period starting from 2 weeks after Dose 2 until one year of age.
- Trial name
- NCT00140673
- Testing
- Rotavirus
- Where
- 17 sites in Argentina, Brazil and 10 more
- Volunteers
- 63,227 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hepatitis E Infection
Safety and Immunogenicity of Hecolin® in Healthy Pregnant Women
This is a phase II randomized, observer-blinded, placebo-controlled study with 3 arms enrolling a total of 2,358 participants. The arms are composed of Arm 1, pregnant participants receiving Hecolin® (N=1,104) with immunogenicity…
- Trial name
- NCT05808166
- Testing
- Hecolin® (Recombinant Hepatitis E Vaccine (Escherichia coli))., Isotonic Sodium Chloride injection
- Where
- Pakistan
- Volunteers
- 2,358 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Respiratory Syncytial Virus Infection
Study on a Live-attenuated Respiratory Syncytial Virus Vaccine for Assessment of Safety, Transmissibility, and Genetic Stability of the Vaccine Virus Among Close Contacts in Infants and Toddlers 6 to < 24 Months of Age in Puerto Rico (USA)
The primary purpose of the study is to assess the shedding, transmission, and genetic stability of the live-attenuated RSVt vaccine after each intranasal vaccination (56 days apart) in infants and toddlers 6 to < 24 months of age.
- Trial name
- NCT05687279
- Testing
- RSVt Vaccine, Control Group
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Tonsillitis, Airway Obstruction
Acetaminophen's Efficacy For Post-operative Pain
The purpose of this study is to compare IV acetaminophen to oral acetaminophen for pain control in children undergoing tonsillectomy with or without adenoidectomy.
- Conditions
- Tonsillitis, Airway Obstruction, Difficulty Swallowing
- Trial name
- NCT01721486
- Testing
- IV acetaminophen, PO acetaminophen
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Kaveh Aslani, MD
Dental Crowding, Malocclusion, Angle Class I
Treatment Outcome of Elastomeric and Nickel-Titanium Separators in Tooth Separation
Patients seeking fixed orthodontic treatment that requires band placement will be enrolled in this study. This trial aims to compare the efficiency of rectangular cross-section nickel-titanium separators with elastomeric…
- Trial name
- NCT07591454
- Testing
- Elastomeric separators, Nickel-Titanium separators
- Volunteers
- 30 people
- Sponsor
- 3D-Aligners
Influenza, Human, Respiratory Tract Infections
A Study to Confirm Efficacy of a Single Dose of Baloxavir Marboxil in the Post-exposure Prophylaxis (PEP) of Influenza Virus Infection in Chinese Participants
The main purpose of the study is to evaluate the efficacy of a single dose of baloxavir marboxil compared with placebo in the PEP of influenza virus infection with respect to symptomatic, laboratory-confirmed influenza in…
- Conditions
- Influenza, Human, Respiratory Tract Infections, Post-exposure Prophylaxis
- Trial name
- Pearlstone (NCT07827599)
- Testing
- Baloxavir marboxil
- Where
- 8 sites in China
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Infection, Bacterial
Effect of a Infection Control Program on the Reduction of Bacterial Contamination on NG Tube Feeding in RCHEs
Septicaemia is a potential complication of nasogastric (NG) tube feeding contamination (Leanne, 2014; Anderton, 2000) and a major cause of morbidity and mortality in residential care home for elders ( RCHEs) (Leanne, 2014).
- Trial name
- NCT04075344
- Testing
- Multimodal Infection control programme
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Urinary Tract Infections
Gentamicin Bladder Instillation Trial
Recurrent UTIs are common among patients on IC. These create significant patient morbidity and healthcare burden. In desperation, many physicians prescribe prophylactic oral or intravesical antibiotics.
- Trial name
- NCT01884467
- Testing
- Gentamicin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Gillette Children's Specialty Healthcare
Asthma, Asthma Exacerbations
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers
In this 7-month randomized controlled trial, children aged 1 to less than 6 years, with recurrent asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual…
- Conditions
- Asthma, Asthma Exacerbations, Preschool Child, Vitamin D
- Trial name
- DIVA (NCT03365687)
- Testing
- Vitamin D
- Where
- 9 sites in Canada
- Volunteers
- 323 people
- Sponsor
- Professor Francine Ducharme
Bronchiolitis, Viral
Efficacy and Safety of Curosurf® in Patients Invasively Ventilated for Severe Bronchiolitis Under 12 Months of Age
Background. Viral bronchiolitis is a common cause of hospitalization for acute respiratory insufficiency in young infants. Despite several RCT have tested the effectiveness of various agents, currently there is no proven specific…
- Trial name
- NCT03959384
- Testing
- Curosurf 80Mg/Ml Intratracheal Suspension, Ambient Air
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Infection Control Training
The Effect of Catheter-Associated Infection Control Training
The goal of this type of study: clinical trial is to determine the effectiveness of educational practices on catheter-associated infection control measures on surgical nurses.
- Trial name
- NCT05670119
- Testing
- Structured Training
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Herpes Genitalis, HIV Infection
Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding
Genital herpes is a long-life sexually transmitted diseases which infects a large proportion of women in Africa. Its clinical symptoms are painful sores on the genitals, which heals after a few days.
- Trial name
- NCT00158509
- Testing
- Valacyclovir
- Where
- Burkina Faso
- Volunteers
- 215 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Viral Wart
Evaluation of Combined Treatment With Er:YAG & Nd:YAG Lasers for the Treatment of Recalcitrant Warts
Background: Viral warts are common infectious skin disease induced by human papillomavirus (HPV). Lasers have been used for warts treatment in recent years with variable success rates.
- Trial name
- NCT05768893
- Testing
- Long-Pulsed Nd:YAG Laser 1064nm & Er:YAG Laser 2940nm, Er:YAG Laser 2940nm
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Rambam Health Care Campus
Rhinitis; Allergic, With Asthma
Efficacy Study of Homeopathic Medicines in Treatment of Allergic Rhinitis and/or Induced Bronchial Asthma
The purpose of this study is to test whether individualized homeopathic medicines can produce any significant effect beyond placebo in treatment of allergic rhinitis and/or induced bronchial asthma
- Trial name
- SBRCTHILARBA (NCT02255136)
- Testing
- Individualized homeopathic medicines
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Mahesh Bhattacharyya Homoeopathic Medical College and Hospital
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
IPV, HIV
Tu'Washindi RCT: Adolescent Girls in Kenya Taking Control of Their Health
This study will test the effectiveness of a youth-designed multilevel intervention, Tu'Washindi, to increase PrEP use and reduce intimate partner violence (IPV) among Kenyan AGYW and to identify implementation challenges and…
- Conditions
- IPV, HIV, PrEP
- Trial name
- NCT05599581
- Testing
- Tu'Washindi
- Where
- 2 sites in Kenya
- Volunteers
- 1,562 people, healthy volunteers welcome
- Sponsor
- RTI International
Pregnancy, Malaria
Safe Pregnancy by Infectious Disease Control
Malaria and sexually transmitted infections (STIs) are common in pregnant women in Africa and are important preventable causes of poor birth outcomes and maternal and infant mortality.
- Trial name
- NCT00489619
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 2,008 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Meningococcal Disease
A Study to Evaluate the Safety and Immunogenicity of 4 Doses of MenACWY Conjugate Vaccine, Administered Concomitantly With Routine Vaccines, Among Infants Aged 2 Months
This Phase 3 study is designed to demonstrate the safety and immunogenicity of MenACWY and non-interference of concomitant routine vaccines by MenACWY in an infant age group.
- Trial name
- NCT01000311
- Testing
- MenACWY-CRM, DTaP-IPV/Hib, HBV
- Where
- 46 sites in United States, Australia and 1 more
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
COVID-19
Can Doctors Reduce COVID-19 Misinformation and Increase Vaccine Uptake in Ghana? A Cluster-randomised Controlled Trial
Whilst Ghana was one of the first countries to start vaccinating its population against COVID-19, less than 30% of the population was fully vaccinated at the end of 2022.
- Trial name
- NCT06191211
- Testing
- Motivational Interviewing, AIMS, Facility engagement
- Where
- Ghana
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- London School of Economics and Political Science
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