Clinical trials: Infection Control
Sepsis, Septic Shock
Fluids in Sepsis and Septic Shock
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world.
- Trial name
- FISSH (NCT02748382)
- Testing
- higher chloride crystalloid, higher chloride albumin, lower chloride crystalloid
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
HIV-1, HIV Infections
A Comparison of Virco®TYPE HIV-1 Testing Versus Expert Interpretation of Genotypic Results for Control of HIV-1 Replication
The investigators seek to determine whether Virco®TYPE HIV-1 provides benefits equivalent to those provided by local expert review. The investigators propose that clinic patients of the Ruth M.
- Trial name
- NCT00840762
- Testing
- VircoType HIV-1 genotypic interpretation, Local Expert Review of HIV Genotypic resistance testing
- Where
- United States
- Volunteers
- 756 people
- Sponsor
- Ruth M. Rothstein CORE Center
Human Immunodeficiency Virus (HIV)
Assessment of Group Peer Support to Children With HIV in Vietnam
This project aims to assess the effect of group peer support to children with HIV in relation to adherence, virological treatment failure as well as physical development.
- Trial name
- NCT02035969
- Testing
- Enhanced Treatment Support (ETS)
- Where
- Vietnam
- Volunteers
- 520 people
- Sponsor
- Karolinska Institutet
Dental Infection, Clindamycin
Evaluation of an Educational Intervention on Antibiotics in Dental Care
The goal of this randomized trial is to estimate the impact of personalized prescribing portraits and educational materials on prescribing of antibiotic medications by dentists in British Columbia, Canada.
- Conditions
- Dental Infection, Clindamycin, Antibiotics
- Trial name
- NCT07016217
- Testing
- Early Plain Portrait and Letter, Early Complete Portrait and Letter, No intervention
- Where
- Canada
- Volunteers
- 3,498 people
- Sponsor
- University of British Columbia
HIV Infections
The Safety and Effectiveness of Zidovudine in the Treatment of HIV-Infected Children With Mild to Moderate Symptoms
To determine the safety and usefulness of zidovudine (AZT) for the treatment of children 3 months to 12 years of age. This study is designed to determine if children who are infected with HIV and who have a special type of lung…
- Trial name
- NCT00000990
- Testing
- Zidovudine
- Where
- 33 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Double-Blind, Placebo-Controlled Trial To Evaluate Intravenous Gamma Globulin in Children With Symptomatic HIV Infection Receiving Zidovudine
To evaluate the clinical, immunologic, and virologic effects of oral zidovudine (AZT) plus intravenous immunoglobulin (IVIG) versus AZT plus placebo (albumin).
- Trial name
- NCT00000720
- Testing
- Globulin, Immune, Zidovudine
- Where
- 51 sites in United States, Puerto Rico
- Volunteers
- 250 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Falciparum
Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education.
This study seeks to establish whether intermittent preventive treatment (IPT) can reduce malaria among school-going children and its consequent impact on school performance.
- Trial name
- NCT00142246
- Testing
- Intermittent preventive treatment (SP and amodiaquine)
- Where
- Kenya
- Volunteers
- 6,758 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Upper Respiratory Tract Infection
Montelukast as Prophylaxis for Upper Respiratory Tract Infections in Children: a Randomised, Double-blind, Placebo-controlled Study
Viral upper respiratory tract infection (URI) is one of the most common diseases among toddlers and pre-school children.Complete and effective prevention measures for URI are currently unavailable.
- Trial name
- NCT00551382
- Testing
- Muntelukast
- Where
- 3 sites in Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Enterovirus, Rhinovirus
Efficacy and Safety of Nitazoxanide in the Treatment of Colds Due to Enterovirus/Rhinovirus Infection
Trial to evaluate efficacy and safety of nitazoxanide in the treatment of colds due to Enterovirus/Rhinovirus infection
- Trial name
- NCT03605862
- Testing
- Nitazoxanide
- Where
- 45 sites in United States, Puerto Rico
- Volunteers
- 1,756 people
- Sponsor
- Romark Laboratories L.C.
Coronavirus
Recombinant New Coronavirus Vaccine (CHO Cells) to Prevent SARS-CoV-2（COVID-19） Phase I Clinical Trial (3~17 Years Old)
Popular topic: Phase I clinical trial of recombinant new coronavirus vaccine (CHO cell) (3~17 years old) Research purpose:Main purpose:To evaluate the safety and tolerability of recombinant New Coronavirus vaccine (CHO cells) in…
- Trial name
- NCT04961359
- Testing
- Recombinant new coronavirus vaccine (CHO cell) group
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Preterm Delivery, Hypothermia
Randomized Controlled Trial of Social Network Targeting in Honduras
Social network targeting strategies can be used to improve the delivery and uptake of health interventions. We will enroll approximately 30,000 individuals into a randomized controlled trial of different targeting algorithms in…
- Conditions
- Preterm Delivery, Hypothermia, Diarrhea, Upper Respiratory Infection
- Trial name
- NCT02694679
- Testing
- CBNH
- Where
- 2 sites in United States, Honduras
- Volunteers
- 31,195 people, healthy volunteers welcome
- Sponsor
- Yale University
Infections, Rotavirus
Evaluate Safety & Immunogenicity of 2 or 3 Doses of GSK HRV Vaccine in Healthy Infants in South Africa
The purpose of this study is to determine the appropriate regimen of GSK HRV vaccine for concomitant administration with EPI vaccines to infants in South Africa.
- Trial name
- NCT00383903
- Testing
- HRV vaccine
- Where
- 6 sites in South Africa
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cutaneous Leishmaniasis, Scar
Cosmetic Outcome of Leishmaniasis Scar After WR279396 Application
Primary Objectives: Assess whether CL (caused by Leishmaniasis major) lesions treated with WR279396 improved the cosmetic outcome compared with no treatment (natural healing)
- Trial name
- SCAR (NCT00490230)
- Testing
- WR 279396
- Where
- Tunisia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Croup
Impact of Cold Air Exposure on Croup Symptoms
The goal of the present randomised controlled clinical trial is to compare the efficacy of a 30-minute exposition to cold, atmospheric, outdoor air on the severity of croup symptoms with exposition to indoor room air in children…
- Trial name
- NCT05668364
- Testing
- Outdoor cold air exposure
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
HIV Preexposure Prophylaxis
Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)
The main purpose of the study is to evaluate the safety and tolerability of oral Islatravir (ISL) once monthly (QM) as Preexposure Prophylaxis (PrEP) in cisgender men who have sex with men (MSM) and transgender women (TGW) who…
- Trial name
- Impower-024 (NCT04652700)
- Testing
- ISL, FTC/TDF, FTC/TAF
- Where
- 25 sites in United States, Brazil and 5 more
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hidradenitis Suppurativa
An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa.
The purpose of this study is to compare the efficacy of Provodine™ topical cream to 10% benzoyl peroxide topical body wash for the treatment of early stage hidradenitis suppurativa.
- Trial name
- NCT01818167
- Testing
- 10% Benzoyl Peroxide Topical Body Wash, Provodine Topical Cream
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Pneumococcal Infectious Disease
Clinical Trial of PCV24 in Children Aged 2-17 Years
A Phase Ia clinical trial of 24-valent pneumococcal conjugate vaccine (PCV24) developed by Sinovac Life Science Co., Ltd will be conducted in children aged 2-17 years.
- Trial name
- NCT06550830
- Testing
- Sinovac PCV24 formulation 1, Sinovac PCV24 formulation 2, Prevenar13®
- Where
- China
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Dental Caries, Streptococcal Infections
Evaluation of Efficacy of Antibacterial Activity of Licorice, Clove, and Chlorohexidine Mouthwashes on Salivary Streptococcus Mutans in a Group of Egyptian Children.
A randomized controlled trial that compares the antibacterial effectiveness of three mouthwashes-licorice, clove, and chlorhexidine-in Egyptian children aged 7-12 years.
- Conditions
- Dental Caries, Streptococcal Infections, Mouthwashes
- Trial name
- NCT07828171
- Testing
- Mouth wash
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- British University In Egypt
Xerostomia, COVID-19
The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19.A Randomized Controlled Trial.
Coronavirus (COVID-19) is a newly emerging zoonotic agent that emerged in December 2019 in China (2019-nCoV) as a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV -2).
- Conditions
- Xerostomia, COVID-19, Long COVID, Persistent COVID-19
- Trial name
- NCT05760092
- Testing
- Institutional standard treatment for xerostomia and Long Covid, Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Nove de Julho
Tinea Pedis, Athlete's Foot
Safety and Efficacy of Econazole Nitrate Foam 1% and Foam Vehicle in Subjects With Tinea Pedis
This is a study of the safety and efficacy of Econazole Nitrate Foam 1% and the Foam Vehicle in subjects with interdigital tinea pedis (athlete's foot between the toes).
- Trial name
- NCT01358240
- Testing
- Econazole Nitrate Foam 1%, Vehicle Foam, Econazole Nitrate Cream 1%
- Where
- 12 sites in United States
- Volunteers
- 336 people
- Sponsor
- AmDerma
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