Clinical trials: Infertility, Male
Phimosis, Foreskin; Tightness
Safety and Efficacy of the Sterile Single-use Circular Stapling Device CIRCCURER II (Jiangxi Langhe Medical Instrument Co., Ltd., Guangzhou, China)
Evaluation of the safety and efficacy of the sterile single-use circular stapling device CIRCCURER II (Jiangxi Langhe Medical Instrument Co., Ltd., Guangzhou, China) in comparison with circumcision in adults patients with…
- Conditions
- Phimosis, Foreskin; Tightness, Redundant Prepuce
- Trial name
- CiCi-2021 (NCT04902898)
- Testing
- Circumcision in adults using sterile single-use circular stapling device, Circumcision in adults
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Thessaly
Male Infertility, Female Infertility
IMSI in Couples With Previous Implantation Failures
There is a lack of clarity regarding the justification to instruct the couple to shift from intracytoplasmic sperm injection (ICSI) to intracytoplasmic morphologically selected sperm injection (IMSI).
- Trial name
- NCT02107521
- Testing
- Intracytoplasmic morphologically selected sperm injection, Intracytoplasmic sperm injection
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Sapientiae Institute
Oligoasthenoteratozoospermia, Male Infertility
Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
Objective of the study is to compare the efficacy of tamoxifen alone \& tamoxifen with antioxidant on semen quality of infertile male with abnormal parameters (sperm count, motility, vitality, morphology) .Infertility is defines…
- Trial name
- NCT05200663
- Testing
- Tab Tamoxifen 10 mg, Tab Tamoxifen 10mg,Cap vitamin E 400mg
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sharif Medical Research Center
Endocrine Disease, Infertility
Hormonal Regulation of Puberty and Fertility
Background: The body produces gonadotropin-releasing hormone (GnRH) about every 2 hours. GnRH travels through the bloodstream to the pituitary gland, where it stimulates the gland to produce hormones called gonadotropins.
- Conditions
- Endocrine Disease, Infertility, Hypogonadism, Amenorrhea
- Trial name
- NCT01511588
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Male Subfertility
Role of Immunoglobulin in Male Infertility
to investigate the role of IVIG in male infertility and to determine its benefits in term of semen parameters and assisted reproduction outcome
- Trial name
- NCT06423989
- Testing
- IVIG
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dr Salma kafeel Qureshi
Infertility, Male, Cancer
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy.
- Conditions
- Infertility, Male, Cancer, Autoimmune Disorder
- Trial name
- NCT04452305
- Testing
- Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Klinefelter Syndrome
Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome
The study seeks primarily to determine whether modulation of systemic and testicular sex steroids balance by aromatase inhibitors will positively affect the metabolic health and spermatogenesis of men with Klinefelter syndrome…
- Trial name
- KLIN-HEALTH (NCT05586802)
- Testing
- Anastrozole, Semaglutide, human chorionic gonadotropin
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Georgios Papadakis
Infertility Unexplained, Oligospermia
Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia
Evaluation of treatment with Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile men with Idiopathic Oligoasthenoteratospermia
- Trial name
- infertility (NCT06342856)
- Testing
- co enzyme Q10 , L- Carnitine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Male Infertility
Can the Origin of Sperm Affect Embryo Ploidy in Patients With Severe Male Factor Infertility?
There is evidence indicating that sperm plays a role in determining blastocyst ploidy status. In our study, we aim to compare the outcomes of preimplantation genetic testing for aneuploidy (PGT-A) and the subsequent clinical…
- Trial name
- NCT06476379
- Testing
- Testicular sperm extraction (TESE), Ejaculate
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ganin Fertility Center
Obesity, Oligospermia
Aromatase Inhibitors in the Treatment of Male Infertility
Obesity is associated with an increase in blood levels of estrogen. Estrogen or "female hormone" is believed to have a negative effect on sperm production.
- Trial name
- NCT00440180
- Testing
- Anastrozole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Male Infertility, Unexplained Infertility
Impact of Sperm DNA Integrity on In Vitro Cycles
Sperm DNA integrity will be measured via the Toluidine Blue Assay (TBA) for patients undergoing In Vitro Fertilization (IVF); the study will determine correlations, if any, between IVF success and sperm DNA integrity.
- Conditions
- Male Infertility, Unexplained Infertility, Abortion, Habitual
- Trial name
- TBA on IVF (NCT01232465)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Northwell Health
Sperm Count, Low, Reproductive Sterility
A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome
The investigators plan to retrospectively analyze clinical data from 14,189 fresh ICSI cycles in Reproductive and Genetic Hospital of CITIC-Xiangya from January 2016 to December 2017.The investigators will regard total…
- Trial name
- NCT03594201
- Testing
- semen pretreatment
- Where
- China
- Volunteers
- 12,215 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Male Infertility, Male Subfertility
Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen Parameters
With declining fertility rates Worldwide, Assisted Reproductive Technology is seen as a viable solution for infertility, however, individual success rates following ART remain relatively low, rarely exceeding ~50%.
- Trial name
- PLCZeta (NCT07684339)
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- Fakih IVF Fertility Center
Abnormal Spermatogenesis, Azoospermia
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility
The aim of this study was to assess meiotic recombination in primary spermatocytes, synaptonemal complex length and the correlation with chromosomal abnormalities in testicular spermatozoa from infertile men with idiopathic…
- Trial name
- NCT02339272
- Testing
- non interventional
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Igenomix
MIRAS, Testicular Abnominalies
Could miRNAs be Used as Markers for Distinguishing Undescended Testicles From Retractile Testicles
Background: Undescended testicles (UDTs) are common in male infants. Untreated UDT poses risks such as infertility (IF), testicular cancer (TC), and testicular torsion (TT).
- Conditions
- MIRAS, Testicular Abnominalies, Undescended Testes
- Trial name
- miRNA (NCT07315737)
- Testing
- miRNA
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Dr. Mevlüt Keleş
Reduced Sperm Motility, IVF
Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods
Purpose: To compare the effects of the density gradient centrifugation and microfluidic chip sperm preparation methods on embryo development in a study population with astheno-teratozoospermia.
- Conditions
- Reduced Sperm Motility, IVF, ICSI, Astheno Teratozoospermia
- Trial name
- NCT04962074
- Testing
- Microfluidic sperm sorting chip, Density gradient
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Maltepe University
Varicocele; Male Infertile;Varicocelectomy
The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study
The purpose of this study is to determine whether high ligation of spermatic vein by open operation and microsurgery for patients with are effective in the treatment of varicocele and to determine which surgical option is better.
- Trial name
- NCT01757548
- Testing
- open operation, microsurgery
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Azoospermia, Infertility
Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)
We evaluated the application of surgical testicular exploration with the aid of a microscope (MictoTESE) to increase the chances of obtaining sperm in men with impaired sperm production, a condition known as non-obstructive…
- Trial name
- NCT00484081
- Testing
- Microdissection Testicular Sperm Extraction, ICSI
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Clinic and Research Center in Human Reproduction Roger Abdelmassih
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility, Male
Fertility Preservation in Male AYA With Cancer
Very little is known about how medical providers can help adolescent and young adults (AYAs) and their caregivers make decisions about fertility preservation (sperm banking) before beginning cancer treatment.
- Trial name
- NCT04268004
- Testing
- FP Decision Tool and Discussion
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Leena Nahata