Clinical trials: Inflammation, completed
Asthma
Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
The purpose of this study is to compare the effects of 2 weeks therapy of montelukast, budesonide, their combination on exercise induced bronchoconstriction (EIB) and airway inflammation in children and young adults, not on…
- Trial name
- NCT00462592
- Testing
- budesonide, montelukast
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- Hamilton Health Sciences Corporation
Acute Respiratory Tract Infections, Diarrhea
Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT
Melghat is poorly developed tribal area in India with very high child mortality \& malnutrition prevalence (grossly inadequate medical facilities). Important health problems.
- Conditions
- Acute Respiratory Tract Infections, Diarrhea, Malaria, Neonatal Sepsis
- Trial name
- HBCC (NCT02473796)
- Testing
- Home based child care
- Where
- India
- Volunteers
- 7,594 people
- Sponsor
- MAHAN Trust
Malaria
Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, Liberia
Background: The disease malaria affects many people in Liberia and other parts of Africa. It is caused by germs that are spread by mosquito bites.
- Trial name
- NCT03719599
- Where
- 2 sites in Liberia
- Volunteers
- 1,264 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis, Shock
Noninvasive Assessment of Tissue Perfusion Status in Critically Ill Pediatric Patients
Investigators are conducting research about oxygen levels in the body and whether it is possible to use a device to measure oxygen in the body's tissues noninvasively, without blood draws or a catheter (a plastic tube placed in a…
- Trial name
- NCT01760044
- Testing
- Tissue oxygenation monitoring
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Biomarker, Systemic Inflammation
Study of Systemic Impact of Trace Elements Release by Implantable Medical Devices. Identification of Biomarkers of Systemic Inflammation
The main objective of this study is to evaluate the systemic impact of salting out of trace elements (TE) by metallic and nonmetallic implantable medical devices (IMD) and in particular the immune response of the organism to…
- Trial name
- PROMETOX (NCT03812627)
- Testing
- Blood, urine, hair, synovial fluid and peri-prosthetic tissue collections, Autopsy
- Where
- France
- Volunteers
- 159 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Body Mass Index Quantitative Trait Locus 5 Disorder, Tangier Disease
Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.
- Trial name
- NCT01886495
- Testing
- nutrition intervention
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Pancreatitis
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis
This pilot study is a feasibility, safety, and preliminary benefits study to look at whether giving the calcium channel blocker amlodipine to people with hereditary pancreatitis as a prophylactic measure can reduce the…
- Trial name
- NCT00156403
- Testing
- amlodipine (drug)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Anemia, Iron Deficiency
Iron and Prebiotics Fortification in Kenyan Infants
Iron deficiency and anemia are health issues affecting mainly infants and women in developing countries. Iron deficiency in infancy can have long-lasting impact on cognitive and motor development of the child.
- Conditions
- Anemia, Iron Deficiency, Diarrhea, Malaria
- Trial name
- Iro'n'Pre (NCT02118402)
- Testing
- Fortified maize porridge
- Where
- Kenya
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Sepsis
Epidemiology of Sepsis in China
Sepsis is a common cause for morbidity and mortality in critically ill patients. In USA, the incidence of sepsis is about 3/1000 population. However, the incidence of sepsis varies among different clinic trails.
- Trial name
- NCT02448472
- Testing
- Observational study, none intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Jianfeng Xie
Prenatal Exposure Delayed Effects
Nutrition and Inflammation in Pregnancy: Impacts on Early Human Brain Development in Ethiopia
The goal of this observational child follow-up study is to examine the effects of prenatal nutrition and infection management interventions on long-term child neurodevelopment.
- Trial name
- NCT06296238
- Where
- Ethiopia
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- Brown University
Breast Neoplasms, Fever
A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer
This is a prospective, randomized Phase III trial of FLAC chemotherapy with GM-CSF versus PIXY321 in advanced breast cancer. The primary endpoints of this study will be the duration of thrombocytopenia and the time to recovery of…
- Conditions
- Breast Neoplasms, Fever, Hematologic Diseases, Neutropenia
- Trial name
- NCT00001338
- Testing
- FLAC chemotherapy with GM-CSF
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Bronchiolitis Obliterans
Bronchial Inflammation in Patients With Bronchiolithis Obliterans
The investigators plan to study the variability of lung function parameters and bronchial inflammatory markers in 20 patients with bronchiolitis obliterans at the age of 6 to 25 years compared with an age- and sex-matched control…
- Trial name
- FRABO-02 (NCT01633385)
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Sepsis
Pharmacokinetics and Safety of Piperacillin-tazobactam in Neonates
This is a phase I open label multi-dose study to investigate the pharmacokinetics and safety of piperacillin-tazobactam in infants < 61 days of age with suspected sepsis. There will be four cohorts of 8 infants each: 1.
- Trial name
- NCT00873327
- Testing
- piperacillin-tazobactam
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Phillip Brian Smith
Fungemia
Prospective Population Study on Candidemia in Spain
The aim of this study is to describe the epidemiology of fungal blood infections in Spain (with emphasis on the incidence, fungal species distribution and antifungal susceptibility).
- Trial name
- CANDIPOP (NCT01236261)
- Testing
- Non intervention
- Where
- 29 sites in Spain
- Volunteers
- 730 people
- Sponsor
- Fundacion SEIMC-GESIDA
Sepsis
Sepsis Characterization in Kilimanjaro
The aim of this study is to prospectively evaluate the barriers to care, evaluation, clinical practices, and outcomes for patients presenting with sepsis to hospitals in the Kilimanjaro Region of northern Tanzania.
- Trial name
- SICK (NCT05139459)
- Where
- United States
- Volunteers
- 499 people
- Sponsor
- Duke University
Pregnancy, Malnutrition in Pregnancy
Nutritional and Anti-infective Interventions for Malnutrition in Pregnancy (Beleuman Welbodi)
Acute malnutrition in pregnancy is a risk factor for adverse outcomes in mothers and their unborn children. Undernutrition during pregnancy can result in maternal complications such as life-threatening hemorrhage and hypertensive…
- Conditions
- Pregnancy, Malnutrition in Pregnancy, Nutrition Disorders, Stunting
- Trial name
- NCT03079388
- Testing
- Ready-to-use-supplementary food, Corn-soy-blend, Monthly intermittent preventive treatment of malaria during pregnancy (IPTp)
- Where
- Sierra Leone
- Volunteers
- 1,489 people
- Sponsor
- Washington University School of Medicine
Psoriasis
Randomized Double-Blind Placebo-Controlled Trial Using Recombinant Human Interleukin-10 for Moderate-to-Severe Psoriasis
Several studies have documented an essential role for interleukin-10 (IL-10) in preventing prolonged and exaggerated immune responses to antigens and irritants.
- Trial name
- NCT00001797
- Testing
- Recombinant human interleukin-10
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Fasciitis, Necrotizing
Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis
The investigators examined the hypothesis that serum lactate is raised in early necrotizing fasciitis to a much greater extent than in other differential diagnoses, such as severe cellulitis, and therefore provides a diagnostic…
- Trial name
- NCT01739959
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- National Health Service, United Kingdom
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Asthma, Healthy
Factors Involved in Asthma and Airway Inflammation
Asthma is the third leading cause of preventable admissions to the hospital in the United States. Deaths and diseases associated with asthma increase every year. Asthma is a disorder of airway inflammation.
- Trial name
- NCT00001887
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)