Clinical trials: Inflammatory
Neonatal SEPSIS
Neonatal Sepsis at Neonatal Intensive Care Units in Ghana
Background: Neonatal sepsis is a major contributor to global under five mortality. In developing countries a major proportion of neonatal sepsis is thought to emanate from the healthcare setting, due to challenges in infection…
- Trial name
- NCT03755635
- Testing
- The WHO multimodal hand hygiene strategy
- Where
- Ghana
- Volunteers
- 5,433 people, healthy volunteers welcome
- Sponsor
- Stephanie Bjerrum
Acute Myocardial Infarction
Colchicine in ST-elevation Myocardial Infarction
There is evidence that inflammatory processes may play detrimental role during the acute phase of myocardial infarction The hypothesis of this study is that colchicine, by its anti-inflammatory action, may lead to reduction in…
- Trial name
- NCT01936285
- Testing
- Colchicine 2 mg loading dose; 0.5 mg bid for 5 days
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- G.Gennimatas General Hospital
Sepsis, PROM, Preterm (Pregnancy)
Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates
Preterm infants are born at less than 37 weeks of pregnancy. Sometimes a break or tear in the fluid filled bag that surrounds and protects the infant during pregnancy leads to an untimely birth.
- Conditions
- Sepsis, PROM, Preterm (Pregnancy), Early-Onset Neonatal Sepsis, Preterm Premature Rupture of Membrane
- Trial name
- SAUNA (NCT06377397)
- Testing
- Antibiotics
- Where
- 9 sites in India
- Volunteers
- 1,500 people
- Sponsor
- Indian Council of Medical Research
Ulcerative Colitis
Tacrolimus (FK506) Study in Moderate to Severe Refractory Ulcerative Colitis Patients
This study consists of a 2-week placebo-controlled double-blind inter-group efficacy study in moderate to severe refractory ulcerative colitis (UC) patients followed by a maximum of 12-week open-label efficacy and safety study in…
- Trial name
- NCT00347048
- Testing
- tacrolimus
- Where
- 6 sites in Japan
- Volunteers
- 62 people
- Sponsor
- Astellas Pharma Inc
Healthy Infants, Infants With an Inflammatory Condition
Novel Isotope Dilution Technique to Assess Vitamin A Status
Background: There is no reliable method for vitamin A (VA) assessment for infants and young children. Serum VA concentration is not an authenticate indicator of VA status, while existing deuterium- VA isotope dilution methods to…
- Trial name
- NCT03000543
- Testing
- Vaccine
- Where
- 2 sites in Bangladesh
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Eosinophilic Esophagitis
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine…
- Trial name
- NCT03822325
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Pediatrics, Lobar Pneumonia
Application and Effect Evaluation of Integrated Nursing and Medical Management in Pediatric Lobar Pneumonia
Integrated nursing and medical management significantly improves clinical symptoms and pulmonary function in children with lobar pneumonia, shortens hospitalization duration, reduces complication rates, and enhances caregiver…
- Conditions
- Pediatrics, Lobar Pneumonia, Inflammatory Markers, Satisfaction
- Trial name
- NCT06945991
- Testing
- observation group, control group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Hebei Province
Colitis, Ulcerative
A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis
The purpose of this study is to evaluate the pharmacokinetics (what the body does to the study medication) and safety of subcutaneously (under the skin) administered golimumab in pediatric participants (aged 2 to 17 years) with…
- Trial name
- NCT01900574
- Testing
- Golimumab
- Where
- 27 sites in United States, Austria and 8 more
- Volunteers
- 35 people
- Sponsor
- Janssen Research & Development, LLC
Crohn Disease, Ulcerative Colitis
Expanded Access to Upadacitinib
This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to upadacitinib prior to approval by the local regulatory agency. Availability will depend on territory eligibility.
- Conditions
- Crohn Disease, Ulcerative Colitis, Idiopathic Arthritis (Including sJIA, pJIA, or JPsA), Atopic Dermatitis
- Trial name
- NCT04159597
- Testing
- Upadacitinib
- Sponsor
- AbbVie
Critical Illness, Severe Sepsis
A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children
1. To research the current situation of severe infection in children in China, and to investigate the incidence, prognosis and disease burden of severe infection in children in different regions of China. 2.
- Trial name
- NCT04955210
- Testing
- Not applicable（Cohort study）
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Children's Hospital of Fudan University
Crohn Disease
Fecal Microbiota Transplantation as the First-line Treatment in Active Pediatric Crohn's Disease
To explore the safety and effectiveness of repeated and multiple fecal microbiota transplantations (FMTs) plus partial enteral nutrition (PEN) as a first-line treatment for active Crohn's disease (CD) in children.
- Trial name
- FMT (NCT05321758)
- Testing
- Fecal Microbiota Transplantation, Immunosuppressive Agents
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Sepsis, Neonatal
Comparison Between Split Septum and Mechanical Valve Needleless Connector in Preterm Babies
The goal of this clinical trial study is to compare the effectiveness between split septum and mechanical valve needleless connector in very preterm babies (or under 1500 grams) The main questions it aims to answer are: What is…
- Trial name
- NCT06414174
- Testing
- Split septum needleless connector, Mechanical valve needleless connector
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Neonatal SEPSIS
Severity Index of Neonatal Septicemia Using Score for Neonatal Acute Physiology (SNAP) II
To determine the effect of Score for Neonatal Acute Physiology II as a Predictor of Mortality and Organ Dysfunction in Neonates with Septicemia in the Neonatal Intensive Care Units at CHILDREN'S HOSPITAL, CAIRO UNIVERSITY and at…
- Trial name
- SNAP (NCT03746743)
- Testing
- score for neonatal sepsis
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmed Mahmoud Ali Ali Youssef
Inflammatory Bowel Disease, Crohn's Disease
The Role of Gut Microbiome in Predicting Comorbidities and Complications in Children With Inflammatory Bowel Disease
Background: Bacteria and other microorganisms that live in the intestines (the gut microbiome) play an important role in a person s health. The gut microbiome helps to regulate the immune system and control inflammation.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT05652491
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis
Evaluation of the Performance of the IDBIORIV Method in Pathogen Identification and Antibiotic Susceptibility Testing in Patients With Sepsis
Sepsis is a disruption of homeostasis in the human body in response to bloodstream infection and is associated with a high risk of mortality.
- Trial name
- IDBIORIV (NCT06219135)
- Testing
- no intervention - Contamination group, blood sample - Bacteraemia group, no intervention - Emergency group
- Where
- 23 sites in France
- Volunteers
- 1,372 people
- Sponsor
- Hospices Civils de Lyon
Crohn Disease, Ulcerative Colitis
Changes in Faecal Calprotectin Levels and Participation-related Scores Following Three Weeks of Inpatient Rehabilitation
For many people affected by inflammatory bowel disease (IBD), their quality of life and their ability to participate in their professional and social lives are severely restricted.
- Trial name
- NCT05500040
- Testing
- Multimodal Rehabilitation
- Where
- Austria
- Volunteers
- 226 people
- Sponsor
- Pensionsversicherungsanstalt
Ulcerative Colitis (UC)
A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Ulcerative Colitis
The objectives of Sub-Study 1 are to evaluate the efficacy, safety, and pharmacokinetics of risankizumab as induction treatment in subjects with moderately to severely active ulcerative colitis (UC), and to identify the…
- Trial name
- NCT03398148
- Testing
- risankizumab IV, risankizumab SC
- Where
- 430 sites in United States, Argentina and 42 more
- Volunteers
- 1,558 people
- Sponsor
- AbbVie
Ulcerative Colitis, Familial Adenomatous Polyposis
Is Diverting Ileostomy Necessary in Stapled Ileoanal Pouch?
Total proctocolectomy with ileal pouch anal anastomosis is the first choice surgical operation for management of ulcerative colitis and familial adenomatous polyposis.
- Trial name
- NCT01173250
- Testing
- adding diverting ileostomy, omitting diverting ileostomy
- Sponsor
- Mansoura University
Inflammatory Bowel Disease
Infliximab IBD Influenza Vaccine Study
The investigators will compare the immunogenicity of influenza vaccine in adults and children with inflammatory bowel disease by timing of vaccine in relation to maintenance infliximab dosing.
- Trial name
- NCT01666535
- Testing
- Influenza vaccination
- Where
- Canada
- Volunteers
- 137 people
- Sponsor
- University of Calgary
Neonatal SEPSIS
The Role of Neutrophil CD64 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Neonatal Sepsis
Neonatal sepsis (NS) is a rather serious but relatively common health problem. Despite recent advances in the treatment of neonatal infection, mortality and comorbidities remain high.
- Trial name
- NCT03795285
- Testing
- Expression of neutrophil CD64
- Volunteers
- 50 people
- Sponsor
- Assiut University
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