Clinical trials: Inflammatory Biomarkers
Posterior Reversible Encephalopathy Syndrome, Inflammatory Biomarkers
Inflammatory Biomarkers for the Diagnosis of oPRES
The purpose of this study is to explore the inflammatory biomarkers for the diagnosis of obstetric posterior reversible encephalopathy syndrome.
- Conditions
- Posterior Reversible Encephalopathy Syndrome, Inflammatory Biomarkers, Neutrophil-lymphocyte Ratio
- Trial name
- NCT05433870
- Testing
- Whether the PE or E patient combined with PRES
- Where
- China
- Volunteers
- 621 people
- Sponsor
- Dunjin Chen
Juvenile Idiopathic Arthritis (JIA)
Angiogenic Biomarkers in Juvenile Idiopathic Arthritis
The aim of the study is to determine whether serum inflammatory angiogenic markers (eg, semaphorins, CCN1) predict severity of juvenile idiopathic arthritis defined by structural progression and/or therapeutic escalation.
- Trial name
- MAJIC (NCT05534347)
- Testing
- Blood sample, Joint puncture
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
MRI-Based Screening in a Retrospective Cohort Reveals Adverse Prognosis of Asymptomatic Perianal Fistulas in Crohn's Disease: A Long-term Follow-Up Study
The goal of this observational study is to learn about the necessity of imaging screening for perianal fistula in Crohn's disease (CD) patients without perianal symptoms by comparing the natural history and long-term outcomes…
- Trial name
- NCT07555808
- Volunteers
- 669 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
HIV Infections
A Multicenter, Exploratory Study to Evaluate the Effects of Antiretroviral Cessation on Plasma Associated HIV-1 RNA
To evaluate viral load in the blood stream of HIV-infected patients during a 28-day washout following cessation of long-term zidovudine ( AZT ) therapy.
- Trial name
- NCT00000840
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autoimmune, Lupus Erythematosus, Systemic
Effect of Green Tea on Treatment of Lupus
This randomized double blind clinical trial performed on 68 patients (32 in intervention and 36 in control group) diagnosed with SLE.
- Trial name
- NCT02875691
- Testing
- green tea extract
- Where
- Iran
- Volunteers
- 68 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Sepsis
Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool
The overall objective of this proposed research is the derivation of a biomarker-enhanced artificial intelligence (AI)-based pediatric sepsis screening tool (PSCT) (software) that can be used in combination with the hospital's…
- Trial name
- NCT05311046
- Testing
- Pediatric sepsis screening tool (either algorithmic or manual)
- Where
- United States
- Volunteers
- 12,961 people
- Sponsor
- Computer Technology Associates, Inc.
Chronic Apical Periodontitis, Pulp Necrosis
Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.
This randomized clinical trial aims to compare regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) with conventional root canal treatment in mature necrotic anterior teeth with chronic apical…
- Trial name
- REGEN-iPRF (NCT07913399)
- Testing
- Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Myocardial Depression
Macrophage Inhibitory Factor and High-Mobility Group-1 Protein in Children Undergoing Cardiopulmonary Bypass
Introduction: In recent scientific literature, 2 proteins, macrophage migration inhibitory factor (MIF) and high-mobility group-1 protein (HMG-1), have emerged as important mediators of inflammation and sepsis.
- Trial name
- NCT00692432
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Congenital Heart Disease, Sepsis
Pro-Calcitonin Levels Following Pediatric Cardiac Surgery
First, we, the researchers, hope to find out the PCT response to heart surgery in children by taking blood before surgery and each day for four days after surgery.
- Conditions
- Congenital Heart Disease, Sepsis, Infection
- Trial name
- NCT00284570
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Emory University
Abdominal Pain, Rectal Bloodloss
Head-to-head Comparison of Two Fecal Biomarkers to Screen Children for IBD
RATIONALE: A substantial proportion of children and teenagers with suspected inflammatory bowel disease (IBD) referred for endoscopy do not have the disease.
- Conditions
- Abdominal Pain, Rectal Bloodloss, Diarrhea, Inflammatory Bowel Disease
- Trial name
- CACATU (NCT02197780)
- Where
- 19 sites in Belgium, Netherlands
- Volunteers
- 355 people
- Sponsor
- University Medical Center Groningen
Infectious Disease, Fever
Validation of a Proteomic Signature and Assessment of Viremia in Children With Fever Without Source
The study is an observational blinded Validation study in pediatric patients below 3 years old with a diagnosis of Fever Without Source (FWS).
- Conditions
- Infectious Disease, Fever, Viremia
- Trial name
- NCT03224026
- Where
- Switzerland
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Periodontal Inflammation
Inflammation in Clear Aligners With and Without Attachments
Problem: Clear aligner therapy is widely used in orthodontics due to improved periodontal outcomes compared to fixed appliances.
- Trial name
- NCT07506993
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Necrotizing Enterocolitis
Administration of Arginine Supplementation in Preterm Infants
Calprotectin is a cytosolic component of neutrophils .Fecal calprotectin(FC) is a useful marker for exacerbation of inflammatory bowel disease in children .FC may be a useful marker for necrotizing enterocolitis (NEC).
- Trial name
- NCT01336998
- Testing
- arginine
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Alexandra Hospital, Athens, Greece
Acute Febrile Illness, Bacterial Infections
AI-Guided Proteomic Biomarker Panel for Differentiating Bacterial and Viral Infections in Acute Febrile Illness
This study is a proteomics-based diagnostic biomarker study conducted on the same patient cohort as the transcriptomic biomarker study (NCT065529754).
- Conditions
- Acute Febrile Illness, Bacterial Infections, Viral Infections, Sepsis
- Trial name
- NCT07205575
- Testing
- Proteomic Biomarker Panel
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Qilu Hospital of Shandong University
Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-Cov-2
Paediatric Inflammatory Multisystem Syndrome During COVID-19 Pandemic
During the COVID-19 pandemic, a small minority of children have been presenting to acute paediatric services with a new syndrome, Paediatric Inflammatory Multisystem Syndrome temporally associated with SARS-Cov-2 (PIMS-TS).
- Trial name
- NCT04761913
- Where
- 6 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Anglia Ruskin University
Chronic Obstructive Pulmonary Disease
Identifying Inflammatory Biomarkers of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a condition that is characterized by airway obstruction due to inflammation. Levels of inflammatory proteins may be linked to when and to what extent COPD develops.
- Trial name
- NCT00394940
- Where
- United States
- Volunteers
- 2,085 people
- Sponsor
- University of Arizona
Neonatal Sepsis, Markers
Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis
1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography. 2. To assess sepsis induced cardiac dysfunction. 3.
- Trial name
- NCT07572916
- Testing
- cardiac troponin, and blood culture
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Asthma, Healthy
Inflammatory Markers in Exhaled Breath (Condensate) in Childhood Asthma
Background: Exhaled nitric oxide and inflammatory biomarkers in exhaled breath condensate may be useful to diagnose and monitor childhood asthma.
- Conditions
- Asthma, Healthy, Children
- Trial name
- NCT00404976
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Postoperative Delirium, Pediatric Anesthesia
Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision
Postoperative delirium may occur in children after general anesthesia, even following short procedures such as circumcision. Preoperative systemic inflammation has been associated with postoperative delirium in adults, but data…
- Conditions
- Postoperative Delirium, Pediatric Anesthesia, Inflammatory Biomarkers
- Trial name
- NCT07323485
- Testing
- Measurement of Preoperative Inflammatory Biomarkers
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital