Clinical trials: Inflammatory Conditions
Obesity
Effects of VSL#3 on Metabolic, Endocrine, Lipidomic and Inflammatory Parameters of Pediatric Patients With BMI>90°
Obesity in children has become a significant social problem considering that nowadays 4 to 5 % of all children are obese in the industrialized countries with increased incidence in Europe by 10 to 50% over the past 10 years.
- Trial name
- VAIIO (NCT01650025)
- Testing
- VSL#3 active probiotic
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Malaria
Impact of TMP-SMX Prophylaxis on Malaria Infection and Immunity in Children in Uganda
Background: Malaria is a disease that affects many children and adults in Uganda and Africa. If it is not treated, it can make some people severely ill.
- Trial name
- NCT02094508
- Where
- Uganda
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Charcot-Marie-Tooth Disease, Peripheral Neuropathy
NT-3 Levels and Function in Individuals With CMT
This study will assess the serum NT-3 levels in individuals with the diagnosis of peripheral neuropathy or any type of Charcot-Marie-Tooth Neuropathy (CMT) and correlate this with function.
- Conditions
- Charcot-Marie-Tooth Disease, Peripheral Neuropathy, Chronic Inflammatory Demyelinating Polyneuropathy
- Trial name
- NCT05011006
- Testing
- NT3 blood draw
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Zarife Sahenk
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Electronic Application of a Severe Sepsis Screening Tool and Management Bundle
Thousands of children die from Sepsis following routine infections. Many of these deaths can be prevented with earlier recognition and focused management.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- eASSIST-M (NCT01724463)
- Testing
- Severe Sepsis Management Bundle
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- University of Tennessee
Multi-Drug Resistant Organisms, Late-Onset Sepsis, Neonatal
Using Antibiotics Wisely - An Antimicrobial Stewardship Program
There are significant variations in antimicrobial consumption across Canadian Neonatal Intensive Care Units (NICUs). Inappropriate and overuse of antibiotics can result in antimicrobial resistance and adverse outcomes among…
- Conditions
- Multi-Drug Resistant Organisms, Late-Onset Sepsis, Neonatal, Antimicrobial Resistance
- Trial name
- NCT04388293
- Testing
- Exposure of interest
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University of British Columbia
Sepsis, Septic Shock
IVC Collapsibility Index or CVP as a Predictor of Fluid Responsiveness in Pediatric Sepsis
Pediatric population who suffered from sepsis due to perforated viscus will receive fluid resuscitation guided by either central venous pressure or guided by IVC collapsibility index.
- Conditions
- Sepsis, Septic Shock, Perforated Viscus, Hospitalism in Children
- Trial name
- NCT06833333
- Testing
- Central venous catheter, IVC collapsibility index
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Nosocomial Infection, Bacteremia
Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections
Patients in the intensive care unit are at risk for many infections because the severity of illness and the procedures necessary to care for them.
- Conditions
- Nosocomial Infection, Bacteremia, Sepsis, Pneumonia
- Trial name
- NCT00130221
- Testing
- 2% chlorhexidine gluconate impregnated cloth, Daily bathing with Bar soap
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Cook County Health
SIRS, Sepsis
Evaluation of CDSS in Detection of SIRS and Sepsis in Pediatric Patients
This trial aims to evaluate the accuracy of a Clinical Decision-Support System to support early recognition of SIRS in paediatric intensive care patients.
- Conditions
- SIRS, Sepsis, Pediatric SIRS
- Trial name
- CADDIE2 (NCT03661450)
- Testing
- Clinical Decision-Support System
- Where
- Germany
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Sepsis
Controlled Fluid Resuscitation in Sepsis
To evaluate two different strategy of fluid resuscitation in sepsis patients
- Trial name
- NCT03214913
- Testing
- Early Goal Directed Therapy, Ruijin Strategy
- Volunteers
- 550 people
- Sponsor
- Ruijin Hospital
Sepsis
Neonatal Procalcitonin Intervention Study
In neonates, clinical signs and symptoms associated with early-onset sepsis are non-specific and currently available tests have poor positive and negative predictive values.
- Trial name
- NeoPInS (NCT00854932)
- Testing
- Procalcitonin-guided decision making
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- Luzerner Kantonsspital
Heart Failure，Congestive
Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)
The investigators sought to evaluate the effectiveness of treatment with furosemide + HSS in terms of reduction of serum levels of some chosen markers of heart failure and the response in terms of these markers at a compensated…
- Trial name
- NCT04628325
- Testing
- Furosemide
- Where
- 2 sites in Italy
- Volunteers
- 136 people
- Sponsor
- University of Palermo
Candidiasis
Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia
The purpose of this study is to determine the efficacy and safety of micafungin (FK463) versus liposomal amphotericin B (AmBisome) in treating neutropenic and non-neutropenic patients with confirmed invasive candidiasis or…
- Trial name
- NCT00106288
- Testing
- Micafungin, Liposomal Amphotericin B
- Where
- 37 sites in United States, Canada
- Volunteers
- 637 people
- Sponsor
- Astellas Pharma Inc
Hypertension
Evaluating the Relationship Between Inflammation, Genetics, and Stress in the Development of High Blood Pressure
High blood pressure affects nearly one third of all individuals in the United States. If left untreated, it can lead to stroke, heart failure, heart attack, kidney failure, or blindness.
- Trial name
- NCT00384241
- Testing
- Induced Stress, Buccal Swab
- Where
- United States
- Volunteers
- 1,099 people, healthy volunteers welcome
- Sponsor
- Augusta University
Nephrolithiasis, Urinary Tract Infection (UTI)
Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2
This study will be a multi-institutional randomized clinical trial of a short course of pre-operative antibiotic prophylaxis in addition to perioperative antibiotics prior to undergoing percutaneous nephrolithotomy.
- Conditions
- Nephrolithiasis, Urinary Tract Infection (UTI), Sepsis
- Trial name
- PNLABXPART2 (NCT02829060)
- Testing
- Nitrofurantoin 100 MG, 7d, Gentamicin, 5mg/kg, Ampicillin 2g
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of California, San Diego
Sepsis
nSeP: Detecting Neonatal Sepsis by Immune-Metabolic Network Analysis
Diagnosis of neonatal sepsis remains a challenge due to non-specific signs and diagnostic inaccuracies. Studies have shown that this could lead to overdiagnosis and overuse of antibiotic treatment, with potential long-term…
- Trial name
- nSeP (NCT03777670)
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Cardiff and Vale University Health Board
Tooth, Impacted
Bradykinin Receptors and Pain
This study will examine whether bradykinin receptors are produced at the site of wisdom tooth extraction and if they contribute to the amount of inflammation and pain that follows surgery.
- Trial name
- NCT00083356
- Testing
- Wisdom tooth extraction
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Nursing Research (NINR)
HIV Infections
HIV in Specific Parts of the Body of Patients Who Are Changing or Starting Potent Anti-HIV Drugs
The purpose of this study is to gain information on how the type and amount of HIV present in certain places in the body and in the blood are affected when potent (powerful) anti-HIV drugs are given.
- Trial name
- NCT00007488
- Where
- 23 sites in United States
- Volunteers
- 164 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neonatal Sepsis
White Blood Cells and Platelets Indices as a Prognostic Factor in Neonatal Sepsis
Sepsis is a complex condition initiated by a pathogen and mediated by cytokines followed by immune, inflammatory, and coagulation homeostasis disturbances, its evolution being dictated by a complicated balance between pro…
- Trial name
- NCT03880305
- Testing
- complete blood count
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
EBV Viremia, CMV Viremia
25BT056: Basket Study of Viral Cytotoxic T Lymphocytes
This study is evaluating the safety and effectiveness of virus-specific cytotoxic T lymphocytes (vCTLs) for treating difficult-to-control viral infections caused by cytomegalovirus (CMV), adenovirus (ADV), Epstein-Barr virus…
- Conditions
- EBV Viremia, CMV Viremia, BK Viremia, Adenovirus
- Trial name
- NCT07873970
- Testing
- Virus-Specific Cytotoxic T Lymphocytes (vCTLs)
- Volunteers
- 35 people
- Sponsor
- Children's Hospital of Philadelphia
Prematurity, Infections, NIRS
The Peripheral(-Muscle) Oxygenation and Perfusion Score as a New Non-invasive Tool to Predict Elevations in C-reactive Protein Levels in Neonates
This is a prospective, single-center Phase II observational study investigating the predictive value of the "Peripheral(-muscle) Oxygenation and Perfusion Score" (POP-Score), a novel non-invasive composite index, for early…
- Conditions
- Prematurity, Infections, NIRS, Near Infrared Spectroscopy, Preterm Neonates
- Trial name
- POP-Score (NCT07109856)
- Testing
- POP-Score Assessment, Near-Infrared Spectroscopy (NIRS)
- Where
- Austria
- Volunteers
- 93 people
- Sponsor
- Medical University of Graz
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