Clinical trials: Inflammatory Response
Neonatal Respiratory Distress Syndrome, Inflammatory Response
Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS
An Exploratory Randomized double-arm controlled trial to evaluate the immunomodulatory effect of low versus high dose of Alveofact with or without Budesonide.
- Conditions
- Neonatal Respiratory Distress Syndrome, Inflammatory Response, Premature Lungs, Neutrophil Extracellular Trap Formation
- Trial name
- NCT06367881
- Testing
- Alveofact, Budesonide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Perioperative Inflammatory Response, Postoperative Pain
Suprazygomatic Maxillary Nerve Block Effect on Systemic Inflammatory Response in Cleft Palate Surgeries
the aim is to determine the value of adding bilateral supra zygomatic maxillary nerve block to general anesthesia in attenuating the systemic inflammatory response in paediatrics.
- Trial name
- NCT05495750
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alaa Mohamed Abdel Salam Ibrahim Soliman
Sepsis, Non-Infectious Systemic Inflammatory Response Syndrome
Gene Expression Objective Definition of Early Sepsis In Children
GEODESIC is a prospective descriptive cohort investigation that will examine the generalizability of the novel host gene expression biomarkers, SeptiCyteTM LAB, SeptiCyteTM VIRUS, SeptiCyteTM BACT, and SeptiCyteTM TRIAGE…
- Trial name
- GEODESIC (NCT06231862)
- Testing
- SeptiCyte (various)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Seattle Children's Hospital
Sepsis
Using Biomarkers to Optimize Antibiotic Strategies in Sepsis
The proposed work will provide critical insights into the potential impact of a biomarker-based algorithm on reducing unnecessary antibiotic use in different adult and pediatric/neonatal ICU's.
- Trial name
- NCT02207114
- Testing
- Biomarker Algorithm Intervention
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- University of Pennsylvania
Critical Illness, ARDS
The RIsk Stratification in COVID-19 Patients in the ICU Registry
The Risk stratification in COVID-19 patients in the ICU (RISC-19-ICU) registry was founded during the emerging SARS-CoV-2 pandemic.
- Conditions
- Critical Illness, ARDS, Inflammatory Response, COVID-19
- Trial name
- RISC-19-ICU (NCT04357275)
- Testing
- ICU treatment
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- University of Zurich
Covid19, Thrombosis
Registry of Hospitalized Patients in University Hospital Dubrava Respiratory Center
Aim of this project is to understand clinical features, clinical outcomes and efficacy and safety profiles of different therapies by analyzing a cohort of COVID-19 patients hospitalized and treated in a tertiary-level…
- Conditions
- Covid19, Thrombosis, Bleeding, Sepsis
- Trial name
- COVID-19 (NCT05151094)
- Testing
- Observation
- Where
- Croatia
- Volunteers
- 6,000 people
- Sponsor
- University Hospital Dubrava
Pneumoperitoneum, Pain
Effect of Low-pressure Pneumoperitoneum on Pain and Inflammation in Laparoscopic Cholecystectomy
The purpose of this study is to assess the effect of low-pressure pneumoperitoneum on post operative pain and inflammation in patients undergoing elective laparoscopic cholecystectomy by comparing it to standard practice.
- Conditions
- Pneumoperitoneum, Pain, Inflammatory Response
- Trial name
- NCT05530564
- Testing
- low-pressure pneumoperitoneum, standard-pressure pneumoperitoneum
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- University of Jordan
Inflammatory Response, Sports Performance
Dairy Consumption During a High-intensity, High-volume Training Week in Young Athletes
Our proposed study is a 5-d double-blind randomised cross-over trial, seeking to simulate a training identification camp in competitive adolescent soccer players The purpose of the proposed study is to investigate whether…
- Trial name
- NCT03947801
- Testing
- Greek Yogurt, Isoenergetic carbohydrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brock University
Inflammatory Response
Inflammatory Markers and Cbc Indices in Severely Malnourished Children
The main objectives of this study were to correlate between inflammatory markers and cbc indices in severly malnourished children and to determine whether children with SAM can mount an acute phase reactant response namely CRP…
- Trial name
- NCT04608643
- Testing
- CBC _inflammatory markers _ platelet function test
- Volunteers
- 30 people
- Sponsor
- Assiut University
Fibrinogen Abnormality, Telomere Length, Mean Leukocyte
Pediatric ACEs Screening and Resiliency Study
Stressful and traumatic experiences in childhood (Adverse Childhood Events, or ACEs) have been associated with poor health outcomes that extend into adulthood.
- Conditions
- Fibrinogen Abnormality, Telomere Length, Mean Leukocyte, Atopic, Acute Infection
- Trial name
- PEARLS (NCT04182906)
- Testing
- Care Coordination, Resiliency Clinic, Usual Care
- Where
- United States
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Sex Differences in Immune Response, Acute Inflammatory Diseases in Children
Study of the Sex Differences in Inflammatory Diseases in Children
Sexual differences in innate immune response have been demonstrated and were mainly attributed to the influence of the sex steroids (1-18).
- Trial name
- SepsiX (NCT04815811)
- Testing
- Blood collection, Stool collection
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Queen Fabiola Children's University Hospital
Severe Infection
Validation of the Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) in Obstetric Patients
Research problem: In 1991, the terms Systemic Inflammatory Response Syndrome (SIRS), severe sepsis, and septic shock were introduced, based on the pro-inflammatory theory, conforming to a list of classification criteria for each…
- Trial name
- COLOSSAL (NCT04621539)
- Where
- Colombia
- Volunteers
- 2,125 people
- Sponsor
- Fundación Grupo de Investigación en Cuidados Intensivos y Obstetricia
Inflammatory Response
Relationship Between NLR and Prealbumin Levels With Diaphragm Thickness
A study to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.
- Trial name
- NCT04014439
- Testing
- Ratio of Neutrophil to Lymphocyte, Level of Prealbumin Serum
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Indonesia
SEPSIS SYNDROME
Clinical Trial for Valuation of the Effectiveness of Lactoferrine in the Prevention of Sepsis in New Premature Born. Bimonitorization of the Antinflammatory Mechanisms, Antioxidants and the Intestinal Microbiote.
To evaluate the efficacy of enteral administration of bovine lactoferrin (bLf) in the reduction of probable late sepsis or microbiologically proven in preterm infants with birth weight ≤ 1500 gr and / or gestational age ≤ 32…
- Trial name
- LACTOPREM (NCT03472170)
- Testing
- Enteral administration of bovine lactoferrin (bLf)
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Congenital Heart Defect, Cardiopulmonary Bypass
Prognostic Markers of Inflammation in Infants Undergoing Cardiopulmonary Bypass
This study evaluates the effect of heart-lung bypass on babies undergoing cardiac surgery. The investigators want to learn more about the inflammation that exposure to bypass creates in the body by studying markers of…
- Conditions
- Congenital Heart Defect, Cardiopulmonary Bypass, Inflammatory Response, Low Cardiac Output Syndrome
- Trial name
- ProCard (NCT03143348)
- Testing
- Single blood draw, Multiple blood draws
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Oklahoma
Clinical Infection, Microbial Colonization
Effect of Gut Microbiota and Fecal Inflammatory Marker on Childhood Gastroenteritis
Childhood gastroenteritis establishes gastrointestinal disease and increase the economic burden, and the pediatric population is especially vulnerable to these gastrointestinal infections.
- Conditions
- Clinical Infection, Microbial Colonization, Gastroenteritis, Inflammatory Response
- Trial name
- NCT03856138
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Inguinal Hernia, Indirect, Children, Only
Inflammatory Stress Response in Pediatric Inguinal Hernia Repair
Today there are various surgical techniques for inguinal hernia. In this study, investigators want to compare the ''PIRS'' operating technique laparoscopy and modified "Marcy" operating technique with open inguinal access.
- Conditions
- Inguinal Hernia, Indirect, Children, Only, Inflammatory Response, Surgery
- Trial name
- NCT03203343
- Testing
- Operation - PIRS, Operation - MARCY
- Where
- Croatia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Obesity, Childhood, Asthma in Children
Asthma and Obesity Diet Versus Exercise
Obesity is recognized as a pro-inflammatory condition associated with multiple chronic diseases, including asthma. The specific mechanisms linking asthma and obesity remain hypothetical.
- Conditions
- Obesity, Childhood, Asthma in Children, Inflammatory Response, Metabolic Syndrome
- Trial name
- NCT03644355
- Testing
- Lifestyle counseling
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Genotypes and Phenotypes in Pediatric SIRS and Sepsis
The aim of this investigation is to longitudinally quantify host gene expression and serum proteins in children with infectious and non-infectious SIRS.
- Trial name
- GAPPSS (NCT02728401)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Seattle Children's Hospital
Gastric Cancer, Neoadjuvant Chemotherapy
The Analysis of Immuno-Nutrition Index in Advanced Gastric Cancer Receiving Preoperative Treatments
Based on multiple studies, the immune (systemic inflammation) and nutrition index were correlated with short- and long-term prognosis for gastric cancer.
- Conditions
- Gastric Cancer, Neoadjuvant Chemotherapy, Neoadjuvant Chemoradiotherapy, Systemic Inflammatory Response Syndrome (SIRS)
- Trial name
- NCT03493880
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University