Clinical trials: Injectables
Visceral Leishmaniasis
Safety and Efficacy Study of Paromomycin to Treat Visceral Leishmaniasis
Symptomatic Visceral Leishmaniasis(VL)is fatal; Due to the increasing resistance to standard therapy with antimonials, there is a need for new safe, efficacious, low-cost therapies for the treatment of VL.
- Trial name
- NCT00216346
- Testing
- Paromomycin sulfate, Amphotericin B
- Where
- 4 sites in India
- Volunteers
- 667 people
- Sponsor
- PATH
Dental Caries in Children
Clinical and Radiographic Evaluation of Injectable Composite Versus Packable Composite in Restoring of Primary Molars
This randomized clinical trial aims to compare the clinical and radiographic performance of injectable composite versus packable composite in restoring cavitated primary molars in children aged 4 to 8 years.
- Trial name
- NCT07239154
- Testing
- packable composite, injectable composite
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Eslam samy abdel monaem kalboush
Hyaluronic Acid, Fat Graft
Clinical Evaluation of Interdental Papilla Reconstruction Using Injectable Autogenous Fat Versus Hyaluronic Acid Filler.
The goal of this randomized controlled trial is to evaluate the amount of interdental papilla fill following the injection of the fat graft compared to hyaluronic acid filler in patients with interdental papilla deficiency.
- Trial name
- NCT05579522
- Testing
- Fat graft injection, Hyaluronic acid injection
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Urinary Incontinence, Intrinsic Sphincter Deficiency
Injectable Bulking Agent Needle Guide
The purpose of this study is to evaluate the use of the Needle Guide as an assist in properly guiding an injection needle into the appropriate tissue plane during an injectable bulking agent procedure in women using a FDA…
- Trial name
- NG (NCT00763711)
- Testing
- Needle Guided Periurethral Injection
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Carbon Medical Technologies
RT II Gingival Recession
Hyaluronic Acid and Polynucleotides With Connective Tissue Graft and Coronally Advanced Flap for RT II Gingival Recession
This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession.
- Trial name
- NCT07771244
- Testing
- Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University
HIV-1-infection
Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age
The purpose of the study is to evaluate the pharmacokinetics (PK), safety, tolerability, and acceptability of a long-acting injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living with HIV-1, Two to…
- Trial name
- NCT05660980
- Testing
- Once daily CAB tablet + RPV tablet, Long acting CAB injectable + long acting RPV injectable
- Where
- 12 sites in United States, Botswana and 3 more
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
CPP
Efficacy and Safety of Leuprolide Acetate 45 mg in Subjects With Central Precocious Puberty
This study is a multicenter, open-label, single-group, and phase 4 study to evaluate the efficacy and safety of 45 mg of leuprolide acetate in CPP.
- Trial name
- NEST (NCT06926933)
- Testing
- Eligard® 45 mg
- Where
- 9 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- HanAll BioPharma Co., Ltd.
HIV Infections
More Options for Children and Adolescents (MOCHA): Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in HIV-Infected Children and Adolescents
The purpose of this study was to determine the dosage for oral cabotegravir (CAB) and long-acting cabotegravir (CAB LA) and long-acting rilpiverine (RPV LA) and evaluate the safety, acceptability, tolerability, and…
- Trial name
- MOCHA (NCT03497676)
- Testing
- Oral Cabotegravir (CAB), Oral Rilpivirine (RPV), Long-Acting Injectable Cabotegravir (CAB LA)
- Where
- 19 sites in United States, Botswana and 3 more
- Volunteers
- 168 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Crowding of Anterior Maxillary Teeth
Repeated Injections of i-PRF for Decreasing Root Resorption After the Orthodontic Treatment.
Mandibular incisor crowding is a frequent issue that prompts many adults to seek orthodontic treatment. The treatment may enhance patients' quality of life, facilitate dental plaque control, and improve the quality of periodontal…
- Trial name
- NCT07352241
- Testing
- 4-time i-PRF injection group, Saline injection
- Where
- Syria
- Volunteers
- 36 people
- Sponsor
- Damascus University
Root Resorption
Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque
Currently Endodontics looks forward for regeneration rather than repair. Regenerative endodontic therapy was limited to pulp revascularization of necrotic pulp in immature teeth , followed by mature teeth.
- Trial name
- NCT04410679
- Testing
- injectable PRF
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Severe Malaria
Study to Compare Feasibility of 1-step Injectable Artesunate vs. Conventional 2-step Injectable Artesunate
The objectives of this study contains 3 parts: (1) a comparison of 1-step parenteral artesunate (AS) versus conventional 2-step parenteral artesunate in patients with severe malaria to assess the feasibility of administration…
- Trial name
- 1STEP-AS (NCT05140278)
- Testing
- Argesun 60mg (1 step parenteral artesunate), Artesun 60mg (2-step parenteral artesunate)
- Where
- Democratic Republic of the Congo
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Carious Primary, Carious Anteriors
Clinical Assessment of Injectable Composite Versus Packable Composite in Treatment of Carious Primary Anterior Teeth
The aim of this study is to evaluate the clinical success of injectable composite versus packable composite in restoration of primary anteriors.
- Trial name
- NCT06991582
- Testing
- Injectable composite resin restoration, packable composite
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Cairo University
Platelet-rich Fibrin
Effect of Injectable Platelet-rich Fibrin on the En Masse Retraction of Maxillary Anterior Teeth
The aim of this study is to investigate the effect of local injection of injectable platelet rich fibrin (i-PRF) on the rate of orthodontic en masse retraction of anterior teeth clinically and to report any associated pain as…
- Trial name
- NCT05608356
- Testing
- injectable platelet rich fibrin(i-prf)
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Satisfaction, Microbial Colonization
Patient Satisfaction and Microbial Changes in Complete Dentures.
In this research, the investigators are comparing the new thermoplastic material side by side with the conventional poly methyl methacrylate for fully edentulous patients measuring their satisfaction and microbiological count.
- Trial name
- NCT03043456
- Testing
- Thermoplastic complete denture, Conventional acrylic resin complete denture
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
General Anesthetic
HSK3486 (Cipepofol) Injectable Emulsion for Induction of General Anesthesia in Pediatric Subjects Undergoing Elective Surgery
This multicenter, randomized, double-blinded, propofol-controlled Phase 3b study enrolls pediatric subjects aged 3-17 years undergoing elective surgery with endotracheal intubation.
- Trial name
- NCT07510945
- Testing
- HSK3486, propofol
- Volunteers
- 400 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Pleural Effusion, Pleurisy
Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy
This is a prospective study to assess the efficacy and safety of a single dose of cefazolin 2g IV for the prophylaxis of surgical site and pleural space infections in patients undergoing medical thoracoscopy.
- Conditions
- Pleural Effusion, Pleurisy, Empyema
- Trial name
- APT (NCT02446782)
- Testing
- Cefazolin, saline
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Injectable Platelet Rich Fibrin and Microneedling in Papilla Reconstruction, Interdental Papillae Reconstruction
Injectable Platelet-Rich Fibrin and Microneedling For Papillae Reconstruction In Esthetic Zone
The currently available non-surgical techniques for papillary reconstruction did not provide long term maintenance of papillary regeneration, Surgical techniques are invasive and the results are unpredictable .
- Trial name
- iPRFandMN (NCT06021301)
- Testing
- Platelet-Rich Fibrin and Microneedling
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
HIV
Pre-Approval Access to Rilpivirine Long Acting (RPV LA) Injectable Suspension for the Treatment of a Participant With Human Immunodeficiency Virus (HIV)-1 Infection
The main purpose of this pre-approval access program (PAAP) is to provide rilpivirine Long Acting (RPV LA) injectable suspension for the treatment of human immunodeficiency virus (HIV)-1 infection as single patient request to…
- Trial name
- NCT03847376
- Testing
- Rilpivirine Long Acting (RPV LA)
- Sponsor
- Janssen Sciences Ireland UC
Pneumonia
Equivalency Of Oral Amoxicillin Vs Injectable Penicillin In Children With Severe Pneumonia
This is a clinical trial to determine if oral amoxicillin is equivalent in efficacy to injectable penicillin (the standard treatment) in the treatment of WHO-defined severe pneumonia in children between the ages of 2 and 59…
- Trial name
- NCT00227331
- Testing
- Oral amoxicillin
- Sponsor
- Boston Medical Center
Obesity, Over-weight
An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Prader-Willi Syndrome
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics for certain doses of beloranib in obese subjects with Prader-Willi Syndrome.
- Conditions
- Obesity, Over-weight, Prader-Willi Syndrome
- Trial name
- NCT01818921
- Testing
- ZGN-440 sterile diluent, 1.2 mg ZGN-440 for injectable suspension, 1.8 mg ZGN-440 for injectable suspension
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Zafgen, Inc.