Clinical trials: Insulin Dependent Diabetes Mellitus, open to volunteers
Celiac Disease in Children, Diabetes Mellitus, Type I
Auto-antibody Dosage From Blood Spots for Diagnosis of Type 1 Diabetes and Celiace Disease
Early diagnosis of type 1 diabetes and celiac disease is very useful, allows early therapy and prevents deaths from the onset of diabetic ketoacidosis.
- Conditions
- Celiac Disease in Children, Diabetes Mellitus, Type I, Screening
- Trial name
- CELDI (NCT06849622)
- Testing
- Test on blood sample, Test on dried blood sample
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Meyer Children's Hospital IRCCS
Type 1 Diabetes
Effects of Sitagliptin in Relatives of T1D Patients
Type 1 Diabetes (T1D) is a chronic autoimmune disease, with a genetic background, resulting from the immune-mediated destruction of beta cells of the pancreas.
- Trial name
- SITA-one (NCT05219409)
- Testing
- Sitagliptin, Professional CGM
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Milan
Healthy Adult, Type 1 Diabetes (T1D)
Finding Immune Nascent Type 1 Diabetes
The goal of this clinical trial is to understand how many individuals who previously participated in the Indiana Biobank will return a type 1 diabetes home screening kit based upon different methods of recruitment communication.
- Trial name
- FIND T1D (NCT07663136)
- Testing
- phone call, email/mail
- Where
- United States
- Volunteers
- 3,800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Type 1 Diabetes Mellitus (T1DM), Healthy Control
Environmental Determinants of Type 1 Diabetes Risk
To analyze the environmental risk factors for type 1 diabetes in China.
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Healthy Control, Relatives to/Carers of Patients
- Trial name
- NCT07835724
- Where
- China
- Volunteers
- 11,240 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Type 1 Diabetes Mellitus, Stage 2 Type 1 Diabetes
Information, Follow-up and Early Diagnosis of Children at Risk for Type 1 Diabetes
The aim is to investigate whether screening for islet autoantibodies, regular follow-up, and increased knowledge in families about the progression of the disease in children at high genetic risk or with single or multiple islet…
- Conditions
- Type 1 Diabetes Mellitus, Stage 2 Type 1 Diabetes, Stage 1 Type 1 Diabetes, Stage 3 Type 1 Diabetes
- Trial name
- iT1D (NCT06676566)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Lund University
Type 1 Diabetes Mellitus, Diabetes Self-Management Education
DiaBuddy: AI-Enabled Digital Self-Management for Youth With Type 1 Diabetes
The goal of this clinical trial is to learn whether DiaBuddy, a digital self-management app, can help children and adolescents with Type 1 diabetes better manage their condition and reduce the burden experienced by their…
- Conditions
- Type 1 Diabetes Mellitus, Diabetes Self-Management Education, Caregiver Burden
- Trial name
- DiaBuddy (NCT07861373)
- Testing
- DiaBuddy: AI-Enabled Digital Self-Management Intervention, Usual Diabetes Care
- Volunteers
- 140 people
- Sponsor
- Dr. Juwayria Omar
Type 1 Diabetes
Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families
This R01 is in response to RFA-DK-19-021, Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes. The objective is to test the feasibility and acceptability of a novel, practical, and potentially scalable…
- Trial name
- R2D2 (NCT05268250)
- Testing
- R2D2 mHealth intervention
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes
A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil
The objective of this trial is first to evaluate safety and then the effect on preservation of residual beta cell function also clinical efficacy by treatment with Verapamil in children with recent onset Type 1 diabetes.
- Trial name
- VERADIAB-1 (NCT07199946)
- Testing
- Verapamil (Part A)
- Where
- 2 sites in Sweden
- Volunteers
- 36 people
- Sponsor
- Johnny Ludvigsson
Type 1 Diabetes
Cohort Study of Patients With Type 1 Diabetes Registered With Mobile Application in China
For last decade, the innovation of mobile health platform has brought new opportunities for disease management. Previous studies have shown that health management programs based on mobile platforms for patients with diabetes can…
- Trial name
- COOPERATIONS (NCT05163054)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking University Third Hospital
Diabetes, Diabetes (DM)
Time in rANge vs. Time in nOrmal Glycemia for Better Glycemic Control
The TANGO study is a 12-month study involving 120 children and adolescents with Type 1 Diabetes (T1D) across the Czech Republic, Israel, and Poland who use automated insulin delivery (AID) systems.
- Conditions
- Diabetes, Diabetes (DM), Diabetes Type 1
- Trial name
- TANGO (NCT07376850)
- Testing
- Structured Diabetes Education, Automated Insulin Delivery (AID) System Adjustment
- Where
- 3 sites in Czechia, Israel and 1 more
- Volunteers
- 120 people
- Sponsor
- University Hospital, Motol
Diabetes
Body Composition, Fitness, and Thermoregulation in Young Boys With Type I Diabetes vs. Healthy Soccer Players
The study aims to assess differences in body composition, exercise capacity, and thermoregulation between young soccer players with type 1 diabetes and their healthy peers.
- Trial name
- BCFTYR (NCT06676878)
- Testing
- Incremental exercise
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paweł Korman
Type 1 Diabetes (T1D), Sleep Health
Type 1 Diabetes REst for Metabolic Health
Research has shown a link between poor sleep health and late circadian timing with cardiometabolic health in adolescents with type 1 diabetes (T1D).
- Trial name
- T1DREaM (NCT06627504)
- Testing
- Sleep Health and Circadian Timing Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Precision Administration of Anti-thymocyte Globulin With or Without Verapamil
T cell directed therapy, anti-thymocyte globulin (ATG), in low doses, has been shown to lower HbA1c and preserve endogenous insulin production (measured by C-peptide) in individuals with recently diagnosed type 1 diabetes (T1D).
- Trial name
- NCT06455319
- Testing
- Anti-thymocyte globulin (ATG), verapamil extended release capsule
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Type 1 Diabetes, Diabetic Kidney Disease
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range.
- Conditions
- Type 1 Diabetes, Diabetic Kidney Disease, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- MANATEE-T1D (NCT05065372)
- Testing
- Metformin Hcl 1000Mg Tab, Aminohippurate Sodium 20 % Injection, Iohexol 300 Mg/mL Injectable Solution
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kalie Tommerdahl
Respiratory Diseases, Neurological Disorders
Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents
This study is to investigate breath analysis (breath metabolomics) combined with established bioinformatic tools as a platform for companion diagnostics.
- Conditions
- Respiratory Diseases, Neurological Disorders, Type 1 Diabetes
- Trial name
- EBECA (NCT04461821)
- Testing
- Real-time SESI-MS breath analysis, Off-line breath analysis, Blood analysis
- Where
- Switzerland
- Volunteers
- 3,600 people
- Sponsor
- University Children's Hospital Basel
Type 1 Diabetes
Home-based Oral Glucose Tolerance Test for Type 1 Diabetes Screening
This study aims at quantifying the accuracy of a self-administered fingerstick based glucose tolerance test (GTT@Home) respect to the gold-standard in-clinic venous plasma measures during the oral glucose tolerance test (OGTT)…
- Trial name
- NCT07155252
- Testing
- GTT@Home
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Type 1 Diabetes
Can Mindfulness and Virtual Reality Reduce Stress in Young Adults With Type 1 Diabetes?
The goal of this study is to learn if Mindfulness-Based Stress Reduction (MBSR) can be delivered using virtual reality (VR) technology to emerging adults (youth 16-20 years old) with type 1 diabetes and high levels of stress…
- Trial name
- MBSR-VR (NCT07793097)
- Testing
- Mindfulness-Based Stress Reduction - Virtual Reality, Stress tip sheet
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Wayne State University
Type 1 Diabetes Mellitus
Establishment of Screening Pathway for High-Risk Population of Type 1 Diabetes
This study aims to establish a system for identifying and screening high-risk individuals for type 1 diabetes (T1D) and a standardized management pathway for high-risk individuals. It is a prospective cohort study.
- Trial name
- NCT07468474
- Testing
- Gene polymorphic detection
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Diabetes
Efficacy of Automated Insulin Therapy Early Initiated After Diagnosis on Blood Glucose Control in Children and Adolescents With Type 1 Diabetes
The main objective is to assess whether hybrid closed-loop (HCL) insulin delivery initiated early after diagnosis of Type 1 diabetes (T1D) allows a better efficacy on glucose control than conventional standard insulin therapy…
- Trial name
- APATDIAGNOSIS (NCT06283797)
- Testing
- OmniPod 5, Dexcom G6, PAID questionnaires
- Where
- 4 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes (T1D), Food Insecurity
Pilot of Food Is Medicine Interventions to Reduce Cardiovascular Disease Risk in Children With Food Insecurity and Diabetes
Study Design: This two-arm parallel trial will randomize 12 families to receive 6-weeks of medically tailored meals or produce prescriptions. Both groups will receive nutrition coaching, weekly during the intervention.
- Trial name
- NCT07590817
- Testing
- Produce prescription, Medically tailored meal kits, Nutrition Coaching
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Katelyn Fox