Clinical trials: Intellectual Disabilities
Rett Syndrome
A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome
This study will evaluate the efficacy and safety profiles of the investigational gene therapy, NGN-401, in females with typical Rett syndrome.
- Trial name
- NCT05898620
- Testing
- NGN-401
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 33 people
- Sponsor
- Neurogene Inc.
Down Syndrome, Chromosome Disorders
Collaboration for Down Syndrome Progress (CDP)
The Collaboration for Down Syndrome Progress (CDP) is a long-term study that follows people with Down syndrome of all ages. The goal is to better understand their health, development, and everyday experiences over time.
- Conditions
- Down Syndrome, Chromosome Disorders, Intellectual and Developmental Disabilities
- Trial name
- CDP (NCT07625579)
- Where
- 16 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- RTI International
Borderline Intellectual Functioning (BIF), Intellectual Disability
Co-design of an AI Rehabilitation Program for Children With Borderline Intellectual Disorder
Co-design of an AI Rehabilitation Program for Children With Borderline Intellectual Disorder
- Trial name
- NCT07625592
- Testing
- Tablet-Based AI Cognitive and Language Rehabilitation Program
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Intellectual Disability
Research and Characterization of New Genes Involved in Intellectual Disability
Intellectual disability (ID) occurs in 2 to 3 % of the general population but the cause is identified only in 30 to 60% of cases.
- Trial name
- GeneDefi (NCT01867554)
- Testing
- gene analysis
- Where
- France
- Volunteers
- 8,500 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intellectual Disability, Mild, Muscular Strength
Effects of a Progressive Adapted Physical Education Program on Muscular Strength and Endurance in Adolescents With Mild Intellectual Disability
This randomized controlled trial investigated the effects of a 10-week progressive adapted physical education program on muscular strength and muscular endurance in adolescents with mild intellectual disability.
- Trial name
- PAPE-MID (NCT07599033)
- Testing
- Progressive Adapted Physical Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Inonu University
Autism Spectrum Disorder (ASD), Intellectual Disability
Emotion Intensity Modulates Intention in ASD
This study used eye-tracking to examine how emotional expression intensity (low/medium/high) influences intention understanding in children with ASD, PDD, and TD during a puzzle-search task.
- Trial name
- NCT07597655
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Autism Spectrum Disorder (ASD), Intellectual Disability
Verbal Intent and Gaze Cues on Action Prediction in ASD
A 2×2×3 mixed design (intent word × object type × group: TD, ASD, ID) was used. Age-matched children watched videos and judged which object a model would pick; their choices and eye movements were recorded.
- Trial name
- NCT07597694
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Intellectual Disability, Mother-Child Relations
Enhancing Mother-Child Ties and Psychosocial Wellness Through Arts Among Children With Intellectual Disability and Their Mothers
The caregiving of children with intellectual disability (ID) is intensive and challenging. Caregivers, particularly mothers, are left in a vulnerable and stressful condition.
- Trial name
- NCT05214859
- Testing
- The Dyadic Expressive Arts Group Therapy
- Where
- Hong Kong
- Volunteers
- 157 people
- Sponsor
- The University of Hong Kong
Mental Retardation, Syndromic Obesity
Microarray Analysis in Syndromic Obesity
Comparative genomic hybridization (CGH) array technology has been used in numerous studies on mental retardation, and few chromosomal abnormalities have been identified in patients.
- Trial name
- REMOB (NCT01043198)
- Testing
- Clinical examination and blood sampling for biological and genetic analysis
- Where
- 6 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bordeaux
Intellectual Disability, Mild
Effects of a 12-Week Pickleball Training Program on Cognitive and Motor Skills in Adolescents With Mild Intellectual Disability
This study aims to investigate the effects of a 12-week pickleball training program on cognitive and motor outcomes in adolescents with mild intellectual disability.
- Trial name
- PBID-12 (NCT07586722)
- Testing
- Pickleball Training Intervention Group, Standard Special Education Curriculum
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Elif Top
Cerebral Palsy, Cerebral Palsy (CP)
Assessing Intellectual and Motor Outcomes in High-risk Infants
Cerebral palsy (CP) is a condition when a baby has a brain injury that affects their movement and muscle tone. Some people with CP can have other developmental issues, like learning impairments, but many do not and have isolated…
- Conditions
- Cerebral Palsy, Cerebral Palsy (CP), Cerebral Palsy Children, High-risk Infants
- Trial name
- AIM-High (NCT06857539)
- Where
- 4 sites in Ireland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College Cork
Intellectual Disability
AI-Supported and Traditional Tennis Training in Individuals With Intellectual Disabilities
This study aims to examine the tennis learning experiences of children with mild intellectual disabilities aged 12-18 years by comparing a real-time pose recognition technology-supported teaching approach with a traditional…
- Trial name
- TENN-ID (NCT07577830)
- Testing
- Technology-Supported Tennis Training (Real-Time Pose Estimation-Based Instruction), Traditional Tennis Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Autism, Intellectual Disability
Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability
In addition to the core symptoms, children and adolescents with Autism Spectrum Disorder (ASD) often exhibit disruptive behavior problems including irritability, tantrums, noncompliance, and aggression.
- Trial name
- NCT02914951
- Testing
- Cognitive-Behavioral Therapy, Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yale University
Rare Genetic Disease
Transcriptomic Analysis of Fibroblasts and Blood in Patients With Rare Diseases
This study aims to answer a key question in the field of rare genetic diseases by determining the prevalence of deleterious variants at RNA level in undiagnosed patients with intellectual disability and/or neonatal hypotonia.
- Trial name
- ARNseqFibroSan (NCT07075107)
- Testing
- Blood collection, skin biopsy
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Sjogren-Larsson Syndrome
ADX-629 Therapy for Sjogren-Larsson Syndrome
This research study will determine whether orally administered ADX-629 is safe and has biochemical efficacy in participants with Sjögren-Larsson syndrome (SLS), a rare inherited disorder of fatty aldehyde metabolism The disease…
- Trial name
- NCT05443685
- Testing
- ADX-629
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Nebraska
Intellectual Disability, Mild to Moderate, Adolescence
Real-Time Pose Recognition Technology for Improving Tennis Learning in Individuals With Intellectual Disabilities
This study investigates the effect of real-time pose recognition technology on learning tennis skills in individuals with mild to moderate intellectual disabilities.
- Trial name
- NCT07517016
- Testing
- RPRS Tennis Training, Traditional Face-to-Face Tennis Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Neurodevelopmental Disorders, Intellectual Developmental Disorder
High Depth Exome Sequencing on DNA From a Salivary Sample by Mouth Smear.
Despite technological advances, a genetic etiology has been identified in only about 50% to 60% of patients with Neurodevelopmental disorders (NDDs), with a higher diagnostic yield in the syndromic NDD and IDD subgroups.
- Trial name
- SEPASA (NCT07492199)
- Testing
- genetic
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Behavioural Problems
Effectiveness of Multisystemic Therapy for Adolescents From Families With Intellectual Disabilities
The goal of this observational study is to determine the effectiveness of a specialisation of multisystemic therapy (MST) for adolescents with severe behavioural problems from families with an intellectual disability (ID…
- Trial name
- NCT06032455
- Testing
- Multisystemic therapy, Multisystemic therapy - intellectual disabilities
- Where
- 4 sites in Netherlands
- Volunteers
- 470 people
- Sponsor
- De Viersprong
DDX3X, Mental Retardation, X-linked 102
DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
DDX3X syndrome is a genetic cause of intellectual disability and other neurologic features including, in some cases, autism. Variants in the DDX3X gene are thought to account for 1-3% of unexplained intellectual disability in…
- Conditions
- DDX3X, Mental Retardation, X-linked 102, Autism Spectrum Disorder
- Trial name
- NCT03718910
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Intellectual Disability, Variable, Autism Spectrum Disorder (ASD)
School-Based Sensory Processing and Daily Living Skills-Focused Occupational Therapy Program
This study aims to develop and evaluate a school-based occupational therapy program focused on sensory processing and activities of daily living for children with Autism Spectrum Disorder and Intellectual Disability.
- Trial name
- NCT07326267
- Testing
- Individual School-Based Occupational Therapy Sessions, Sensory Preparation Using Proprioceptive, Vestibular, and Tactile Input, Task-Oriented Activities of Daily Living Training
- Volunteers
- 40 people
- Sponsor
- Çankırı Karatekin University