Clinical trials: Interferon-gamma Release Assay
Tuberculosis
Predictive Values of Next Generation Interferon Gamma Release Assays for Latent Tuberculosis Infection
This study will assess the next generation of blood tests for latent TB infection, which may be able to indicate how treatment is working as well as in diagnosis infection.
- Trial name
- NextGen (NCT02512939)
- Testing
- blood test, not yet marketed, no trade name
- Where
- 5 sites in United Kingdom
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- University College, London
Tuberculosis, Latent Tuberculosis
Prognostic Value of Interferon Gamma Release Assays in Predicting Active Tuberculosis Among Individuals With, or at Risk of, Latent Tuberculosis Infection
The objective of this study is to assess the efficacy of the two current TB (tuberculosis) blood tests (Interferon Gamma Release Assays (IGRA)) compared with the standard skin test (Mantoux Tuberculin Skin Test (TST)), for…
- Trial name
- PREDICT (NCT01162265)
- Where
- 3 sites in United Kingdom
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Public Health England
Tuberculosis, Pulmonary, Interferon-gamma Release Tests
IGRA and Mantoux Response in Children With Suspected Latent or Active TB Infection
The aim of this project is to analyze the potential contribution of IGRA test QuantiFERON-TB Gold In Tube test (QTF-GIT, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent)…
- Conditions
- Tuberculosis, Pulmonary, Interferon-gamma Release Tests, Tuberculin Test
- Trial name
- TBTubercolar (NCT02653404)
- Testing
- IGRA test (QTF-GIT)
- Where
- 3 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Siena
Tuberculosis
Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries
The ERASE - TB study will be conducted in order to fill a critical unmet need for tuberculosis control. Persons who are in contact with an infectious TB case may become infected themselves.
- Trial name
- ERASE-TB (NCT04781257)
- Testing
- New test candidates
- Where
- 3 sites in Mozambique, Tanzania and 1 more
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Michael Hoelscher
Tuberculosis, HIV
Interferon-Gamma Release Assays in Tuberculosis (TB) - HIV Co-infected Children
Tuberculosis (TB) is a disease affecting the lungs that is caused by a germ spread by coughing. TB infection is currently diagnosed by a skin test that has limited accuracy.
- Trial name
- NCT00604617
- Testing
- Interferon-Gamma Release Assay, RT-23
- Where
- South Africa
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Latent Tuberculosis Infection, Tuberculosis
Prospective Comparison of the Tuberculin Skin Test and Interferon-Gamma Release Assays in Diagnosing Infection With Mycobacterium Tuberculosis and in Predicting Progression to Tuberculosis
This is a prospective cohort study of persons tested for latent tuberculosis infection at either high risk for exposure to Mycobacterium tuberculosis or high risk for progression to tuberculosis disease.
- Trial name
- NCT01622140
- Where
- 10 sites in United States
- Volunteers
- 21,334 people
- Sponsor
- Centers for Disease Control and Prevention
Active Tuberculosis, Latent Tuberculosis Infection
Performance Evaluation of the VIDAS TB-IGRA Assay.
This study will evaluate the performance of the VIDAS® Interferon Gamma (IFN-γ) Release Assay (TB-IGRA) assay, which is intended for use as an aid in the diagnosis of tuberculosis infection.
- Conditions
- Active Tuberculosis, Latent Tuberculosis Infection, Non-Tuberculous Mycobacterial (NTM) Pneumonia
- Trial name
- NCT04048018
- Testing
- Blood draw and IGRA test
- Where
- 24 sites in United States, Brazil and 7 more
- Volunteers
- 2,401 people, healthy volunteers welcome
- Sponsor
- BioMérieux
Tuberculosis, Interferon-gamma Release Assay
QuantiFERON Change During Anti-tuberculosis Medication
The aim of this study is to evaluate the change of QuantiFERON-TB gold in tube assay (QFT) during the treatment of active tuberculosis.
- Trial name
- NCT01038830
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Armed Forces Capital Hospital, Republic of Korea
Tuberculosis Infection
Tuberculosis In Children Visiting Friends and Relatives
In countries with a low incidence of Tuberculosis (TB), the incidence remains higher among the immigrant population than among the autochthonous population beyond the first years after arrival in the host country.
- Trial name
- NCT04236765
- Testing
- TB infection-screening benefiting group
- Where
- Spain
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Latent Tuberculosis Infection
Diagnosis of Tuberculosis Infection in Health Care Workers Using Ex-vivo Interferon-gamma Assay
The present study was to evaluate the usefulness of a whole-blood interferon-r release assays (IGRAs) as diagnostic tool of the latent tuberculosis infection for healthcare workers.
- Trial name
- NCT01007396
- Testing
- 1-step tuberculin skin test (TST) and blood sampling
- Where
- South Korea
- Volunteers
- 322 people
- Sponsor
- Samsung Medical Center
Latent Tuberculosis, HIV Infections
Improving Latent Tuberculosis (TB) Diagnosis in Thai Children
The study is a prospective study to improve the diagnosis and management of latent TB in HIV-infected and HIV uninfected children in Thailand.
- Trial name
- TB Px (NCT00947609)
- Where
- 2 sites in Thailand
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- SEARCH Research Foundation
Tuberculosis, Pulmonary
Epidemiologic Study to Assess the IGRA Positivity in Populations With a High TB Burden
The purpose of this study is to conduct a multi-country, multi-site, epidemiologic study designed to assess the proportion of interferon gamma release assay (IGRA) positivity, at site level, and to build capacity to conduct a…
- Trial name
- NCT05190146
- Where
- 36 sites in Bangladesh, Brazil and 12 more
- Volunteers
- 7,203 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute