Clinical trials: Internal Disorders
Premature Birth, Asthma in Children
Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental…
- Conditions
- Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders
- Trial name
- NCT05336890
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Flatfoot, Flexible
Plyometric vs. Intrinsic Foot Muscle Training in Pediatric Flatfoot
The purpose of this study is to investigate how the order of exercises in a training program affects foot mechanics and physical performance in children with flexible flatfoot.
- Trial name
- NCT07884162
- Testing
- Plyometric Training
- Where
- Tunisia
- Volunteers
- 36 people
- Sponsor
- Faculty of Medicine, Sousse
Sleep Apnea Syndrome, Rapid Maxillary Expansion
Evaluation of the Effects of Different Rapid Maxillary Expansion Appliances on Obstructive Sleep Apnea
Rapid maxillary expansion (RME) is a commonly used orthodontic treatment in patients with maxillary constriction to provide skeletal expansion, correct posterior crossbite and resolve naso-respiratory problems by reducing oral…
- Trial name
- NCT04604392
- Testing
- Rapid Maxillary Expansion Treatment
- Volunteers
- 46 people
- Sponsor
- Izmir Katip Celebi University
Generalized Anxiety Disorder (GAD), Insomnia
Clinical Efficacy and Mechanism of rTMS Based on dlPFC in the Intervention of Generalized Anxiety Disorder With Insomnia
To investigate the intervention effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on insomnia symptoms of generalized anxiety disorder patients.
- Conditions
- Generalized Anxiety Disorder (GAD), Insomnia, Repetitive Transcranial Magnetic Stimulation (rTMS)
- Trial name
- NCT06931236
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yanghua Tian
Retinal Detachment
Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment
Purpose: To evaluate the logical surgical approaches in closing macular holes in eyes of proliferative diabetic retinopathy with retinal detachment
- Trial name
- ILMFCMHRDPDR (NCT03618498)
- Testing
- ILM flaps insertion techniques or free ILM flaps.
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Changhua Christian Hospital
Obstructive Sleep Apnea
Prevalence of Sleep Apnoea in Adolescents
Obstructive sleep apnoea (OSA) is associated with a variety of important complications, namely cardiovascular, neurocognitive and metabolic disturbances. The prevalence of OSA is well studied in children and adults.
- Trial name
- NCT03895775
- Where
- Hong Kong
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Restless Legs Syndrome
Dose Escalating Study of Rotigotine in Pediatric Subjects With Restless Legs Syndrome
This was a multicenter, open-label, dose-escalation, Phase 2A study with multiple administrations of the rotigotine transdermal system.
- Trial name
- NCT01495793
- Testing
- Rotigotine
- Where
- 12 sites in United States
- Volunteers
- 42 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Cardiovascular Diseases, Heart Diseases
Improving Hypertension Care for Inner City Minorities
To improve long-term blood pressure BP) control in a predominantly African-American, low SES community of a large city.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005707
- Sponsor
- Baylor College of Medicine
Insomnia
Low-intensity Cognitive-behavioural Therapy for Insomnia
A randomized controlled trial is proposed to compare the effectiveness of workshop-based and self-Help cognitive behavioral therapy for insomnia (CBTI), and sleep hygiene education (SHE) to treat insomnia in Hong Kong adolescent…
- Trial name
- NCT03736694
- Testing
- Cognitive behavioural therapy for insomnia, Sleep hygiene education
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- The University of Hong Kong
Sleep-disordered Breathing (SDB)
Sleep-disordered Breathing and Neurocognitive Assessment in Children and Young Adults
One of main problems in the management of sleep-disordered breathing (SDB) in children and young adults is their screening, and the absence or the weak correlation between clinical symptoms and polysomnography (PSG).
- Trial name
- TRSPed (NCT04971850)
- Testing
- Sleep study
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Posterior Fossa Tumors, Pediatric Tumor of Brain
Predicting Cognitive Dysfunction After Pediatric Posterior Fossa Tumor Surgery
The goal of this observational study is to develop and validate a clinical prediction model to identify risk factors for long-term cognitive dysfunction in children (ages 0-18 years) who have undergone surgical resection of a…
- Trial name
- NCT07350382
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 600 people
- Sponsor
- West China Hospital
Sleep Disordered Breathing, Obstructive Sleep Apnea
Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study
Obstructive sleep-disordered breathing (SDB) in childhood is a disorder of breathing during sleep characterized by intermittent upper airway obstruction.
- Conditions
- Sleep Disordered Breathing, Obstructive Sleep Apnea, Snoring, Obstructive Sleep Disordered Breathing
- Trial name
- NCT01918007
- Testing
- Adenotonsillectomy (AT)
- Where
- 2 sites in Greece
- Volunteers
- 186 people
- Sponsor
- Chania General Hospital "St. George"
Obstructive Sleep Apnea Syndrome
Follow-up Studies of Primary Snoring(PS) and Obstructive Sleep Apnea Hypopnea Syndrome(OSAHS) in Chinese Children
The study is designed to investigate the natural course of Primary snoring in 1-2 years or more and the different effect of drug and surgical treatment applied in children with obstructive sleep apnea (OSAS) by comparing the…
- Trial name
- NCT02447614
- Testing
- Adenotonsillectomy, Conservative treatment, no treatment
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Children's Hospital
Oesophageal Atresia, Congenital Diaphragmatic Hernia
Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
This study is a multi-centre, international, prospective cohort study of congenital anomalies to compare outcomes between LMICs and high-income countries (HICs) globally.
- Conditions
- Oesophageal Atresia, Congenital Diaphragmatic Hernia, Intestinal Atresia, Gastroschisis
- Trial name
- NCT03666767
- Testing
- Comparisons will be made between LMICs and HICs
- Where
- United Kingdom
- Volunteers
- 3,850 people
- Sponsor
- King's College London
Child Development, Sensory Processing
Development, Sensory Profile, and Sleep Quality in Preschool Children Across Different Caregiving Models
This observational study aims to examine developmental status, sensory processing, and sleep quality in preschool children aged 3 to 6 years across different caregiving models.
- Conditions
- Child Development, Sensory Processing, Sleep Quality, Caregiving Models
- Trial name
- NCT07511465
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Lung Diseases, Sleep Apnea Syndromes
Sleep Apnea in Elderly Male Twins
To conduct a genetic analysis of anatomic risk factors for sleep apnea in a well-characterized United States population-based registry of elderly male twins who have been successfully followed for the past 30 years.
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Obesity
- Trial name
- NCT00005525
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity Hypoventilation Syndrome
Alternative of Treatment in Obesity Hypoventilation Syndrome
Primary objectives: evaluate the efficacy of noninvasive ventilation (NIV) treatment versus continuous positive airway pressure (CPAP) and life style modification treatment in Obesity Hypoventilation Syndrome (OHS), with PCO2…
- Trial name
- NCT01405976
- Testing
- life style modification, noninvasive ventilation, CPAP
- Where
- Spain
- Volunteers
- 440 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnea of Adult
Imaging Predictors of Cryolysis Efficacy for Treatment of Obstructive Sleep Apnea
The goal of this observational study is to further evaluate the efficacy and mechanism of action of the Cryosa Procedure, a novel procedure intended to treat obstructive sleep apnea (OSA).
- Trial name
- ICE-OSA (NCT06434558)
- Testing
- Cryosa Procedure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Insomnia, Impulsivity
Effects of CBT-I on Impulsivity and Risk Taking in Youths With Insomnia
Insomnia is prevalent in adolescents. Impulsive behaviours and excessive risk-taking have been linked to the manifestation of psychopathology in youths.
- Conditions
- Insomnia, Impulsivity, Risk-Taking
- Trial name
- NCT07399964
- Testing
- Cognitive Behavioural Therapy for Insomnia, Health-related Psychoeducation
- Where
- Hong Kong
- Volunteers
- 124 people
- Sponsor
- The University of Hong Kong
Insomnia
SleepFix for Youth: Digital Behavioural Therapy for Insomnia With E-Psychologist Support
This pilot randomised, open-label, parallel-group controlled trial will evaluate the feasibility, acceptability and effects of a psychologist-supported digital behavioural therapy for insomnia (dBTi) compared to a wait-listed…
- Trial name
- iSLEEPY (NCT07405775)
- Testing
- SleepFix + e-psychologist support calls, Sleep Health Education (Active control)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Woolcock Institute of Medical Research
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