Clinical trials: Internal Disorders
Urethral Internal Sphincter Morphology, Benign Prostatic Hyperplasia
MRI-DTI Assessment of Urethral Internal Sphincter Ring and Prostate Base Morphology
This is a single-center, observational imaging study designed to evaluate the in vivo morphology of the male urethral internal sphincter ring using magnetic resonance diffusion tensor imaging (MRI-DTI) fiber tracking and to…
- Conditions
- Urethral Internal Sphincter Morphology, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT07694752
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Preparation of Internal Thoracic Artery
Low Thermal Electrosurgical Device for Atraumatic Internal Thoracic Artery Harvesting
Electrosurgery is fundamental to the precise, fast and bloodless preparation of internal thoracic artery grafts in cardiac surgery.
- Trial name
- NCT03510026
- Testing
- Low thermal device preparation
- Volunteers
- 20 people
- Sponsor
- Triemli Hospital
Dental Caries
Xylitol for Caries Prevention in Inner-City Children
The purposes of this study is to determine whether xylitol use in kindergarten school children in addition to oral health education, provision of tooth brush and fluoride paste, fluoride varnish and sealant treatment will reduce…
- Trial name
- NCT01901250
- Testing
- Xylitol gummy bears, Sugar free fiber gummy bears, Oral health education
- Where
- United States
- Volunteers
- 562 people
- Sponsor
- Case Western Reserve University
Insomnia
Helping Young Children Sleep
The investigators are conducting a randomized trial of behavioral treatments for young children with insomnia. The investigators are comparing the improvement in sleep patterns after families are given access to Internet sleep…
- Trial name
- NCT01729715
- Testing
- Internet, DVD
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Pediatric Sleep Apnea, Obstructive Sleep Apnea
Photobiomodulation for Pediatric Hypertrophic Tonsils
Pediatric obstructive sleep apnea is a medical condition where a child has great difficulty with breathing, or stops breathing all together, while asleep.
- Conditions
- Pediatric Sleep Apnea, Obstructive Sleep Apnea, Tonsils Hypertrophy
- Trial name
- NCT05459935
- Testing
- PBM Tonsil Arm
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Obstructive Sleep Apnea
Evidence-based Diagnosis and Management of Pediatric Obstructive Sleep Apnea in Primary Care
Obstructive Sleep Apnea (OSA) is prevalent in children and adolescents and associated with a variety of negative consequences affecting health and cognitive functioning.
- Trial name
- NCT02781376
- Testing
- CHICA OSA, Snoring Identification Only
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Indiana University
Sleep Apnea
Clinical Evaluation of a Paediatric Sleep Diagnosis Technology
The objective of this project is to gather research data and subsequently evaluate algorithms to demonstrate clinical efficacy of a novel sleep apnoea detection system in the paediatric population.
- Trial name
- NCT04031950
- Testing
- Novel wearable paediatric device
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Acurable Ltd.
Down Syndrome, Obstructive Sleep Apnea
Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
This study is a prospective, single-arm study conducted under a common implant and follow-up protocol. The objective will be to follow fifty-seven (57) adolescents and young adults (10-21 years of age), with Down syndrome…
- Trial name
- NCT04801771
- Testing
- Inspire Upper Airway Stimulation (UAS) System
- Where
- 8 sites in United States
- Volunteers
- 57 people
- Sponsor
- Inspire Medical Systems, Inc.
Mental Disorder in Adolescence, Insomnia
Promoting Sleep and Physical Activity Among Adolescent Psychiatric Patients
Mental health disorders pose a significant burden on adolescent populations globally, often accompanied by sleep disturbances. Emerging evidence suggests that addressing sleep issues can improve mental health outcomes, while…
- Conditions
- Mental Disorder in Adolescence, Insomnia, Delayed Sleep-Wake Phase Disorder
- Trial name
- SLEEPAC (NCT06407258)
- Testing
- SLEEPAC
- Where
- 2 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- Christin Lang
Narcolepsy 1, Kleine-Levin Syndrome
Microglial Activation in Narcolepsy Type 1 and Kleine-Levin Syndrome: Positron Emission Tomography (PET) Study in [18F] DPA-714
Type 1 narcolepsy (NT1) is a chronic sleep disorder caused by the selective and irreversible loss of neurons from the hypothalamus, which synthesizes a neurotransmitter: hypocretin (Hcrt) / orexin.
- Trial name
- NARCOGLIE (NCT03754348)
- Testing
- PET scan with tracer injection [18F] DPA-714
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Montpellier
Congenital Diaphragmatic Hernia
Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord
Congenital diaphragmatic hernia (CDH) is a severe birth defect, with a prevalence of 1:2000 to 1:3000 live births where a defect in the diaphragm results in, herniation of the abdominal contents into the chest with subsequent…
- Trial name
- NCT03242044
- Testing
- Congenital diaphragmatic hernia resuscitation with an intact umbilical cord
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Severe Bronchiolitis
Prone Position Effects on Work of Breathing and Intrinsic PEEP in Children With Severe Acute Viral Bronchiolitis
Acute viral bronchiolitis is the first cause of respiratory distress in infant. Airway inflammation increases the respiratory system resistances and dynamic hyperinflation. This leads to an increase in the work of breathing.
- Trial name
- BRONCHIO-DV (NCT02602678)
- Testing
- Supine then Prone position, Prone then supine position
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Hospices Civils de Lyon
Narcolepsy
Assess the Safety and Effectiveness of PROVIGIL Treatment in Children and Adolescents With Excessive Sleepiness
The primary objective of the study is to evaluate the safety and tolerability of treatment with PROVIGIL in children and adolescents with excessive sleepiness (ES) associated with narcolepsy or obstructive sleep apnea/hypopnea…
- Trial name
- NCT00214968
- Testing
- Modafinil
- Volunteers
- 92 people
- Sponsor
- Cephalon
Children, Postoperative Pain
Acupuncture for Tonsillectomy Pain
Pain after tonsillectomy can be severe and last ten days. Various new surgical instruments have been developed over the years in an attempt to reduce postoperative pain with mixed results and increased costs; no single…
- Conditions
- Children, Postoperative Pain, Tonsillar Hypertrophy, Obstructive Sleep Apnea
- Trial name
- NCT01389349
- Testing
- Acupuncture
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Children's ENT of San Diego, Inc.
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Sleep Apnea, Obstructive
Video-respiratory Polygraphy in Children
The diagnosis of obstructive sleep apnea-hypopnea syndrome in children (OSAS) requires a polysomnography (PSG) in a sleep lab with video surveillance and monitoring by a nurse.
- Trial name
- NCT06287333
- Testing
- Polysomnography in routine care
- Volunteers
- 66 people
- Sponsor
- Central Hospital, Nancy, France
High-grade Glioma, Diffuse Intrinsic Pontine Glioma
IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG)
This is a phase I study to assess the safety and feasibility of IL-8 receptor modified patient-derived activated CD70 CAR T cell therapy in newly diagnosed and recurrent CD70+ Pediatric High-Grade Gliomas (pHGG) and Diffuse…
- Trial name
- Peds IMPACT (NCT06946680)
- Testing
- Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Asthma, Children
Addressing Barriers to Physical Activity in Inner-City Schoolchildren With Asthma
This proposal will address the existent gaps in the literature by identifying barriers and facilitators to participation in physical activity in inner-city minority elementary schoolchildren with asthma, more that half of whom…
- Conditions
- Asthma, Children, Physical Activity
- Trial name
- NCT01873755
- Testing
- asthma physical activity intervention
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Montefiore Medical Center
Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG
ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
This is a Phase II open-label study to investigate the safety and efficacy of ACT001 in patients with DIPG and H3K27-altered HGG.
- Conditions
- Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG, Refractory DIPG, Recurrent DIPG
- Trial name
- NCT06838676
- Testing
- ACT001
- Where
- 20 sites in United States, Australia and 3 more
- Volunteers
- 60 people
- Sponsor
- Nationwide Children's Hospital
Smartphone Addiction, Students, Nursing
Motivational Interview Based Intervention Program on Smartphone Addiction and Sleep Quality
Smartphones are the technological devices of our age that are constantly evolving and whose use is becoming more widespread day by day.
- Trial name
- NCT06098274
- Testing
- Motivational interviewing program based on transtheoretical model
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mustafa Yumusak
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