Clinical trials: Internal Disorders
Insomnia
Adapted CBT-I for Adolescents With Insomnia : The DREAM-IT Study
The goal of this study is to test an adapted treatment for teen insomnia in comparison to a waitlist condition. Cognitive Behavioral Therapy for Insomnia (CBT-I) is an intervention that was developed for adults and is sometimes…
- Trial name
- NCT06541886
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Indiana University
Hepatocellular Carcinoma
Title of Manuscript: Development and Internal-external Validation of a Comprehensive Model for Predicting Risk of Post-RFA Recurrence in HCC Patients
Background A predictive model for post radiofrequency ablation (RFA) recurrence in patients with Hepatocellular carcinoma (HCC) that incorporates variables like sleep quality and psychological factors can provide more time to…
- Trial name
- NCT06577272
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Tian'an Jiang
Insomnia, Autism
Sleep in Children With Autism and Intellectual Disability
Purposes: Establish proof-of-concept for home polysomnography in the assessment of sleep disorders among prepubertal school children with autism and intellectual disabilities combined; To explore the diagnostic yield of…
- Conditions
- Insomnia, Autism, Intellectual Disability
- Trial name
- SLEEP-AID IT (NCT06403969)
- Testing
- Applied Behavior Analysis
- Volunteers
- 15 people
- Sponsor
- Värmland County Council, Sweden
Enlargement of Tonsil or Adenoid
Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
Adenotonsillar hypertrophy is the principal cause of obstructive sleep apnea of childhood, yet little is known with regard to its pathophysiologic and molecular mechanisms.
- Trial name
- NCT03541434
- Testing
- Complete Blood Count, Tympanometry, Tonsillectomy and/or adenoidectomy
- Where
- 2 sites in Greece
- Volunteers
- 134 people
- Sponsor
- University of Patras
Hypertension, Obstructive Sleep Apnea
Hypertension and Sleep Disordered Breathing in Pediatrics
The primary objective is to determine the prevalence of sleep disordered breathing in children with primary hypertension or pre hypertension.
- Trial name
- NCT00990899
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NYU Langone Health
Insomnia
Ramelteon Tablets 8mg Drug Use Surveillance: Survey on Insomnia Associated With Sleep-onset Difficulty
The purpose of this study is to investigate the safety and efficacy of ramelteon (Rozerem) when used in the routine clinical setting in patients with sleep-onset difficulty associated with insomnia.
- Trial name
- NCT02058992
- Testing
- Ramelteon
- Volunteers
- 3,339 people
- Sponsor
- Takeda
Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn
Milrinone in Congenital Diaphragmatic Hernia
Infants with congenital diaphragmatic hernia (CDH) usually have pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN) leading to hypoxemic respiratory failure (HRF).
- Conditions
- Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure, Pulmonary Hypoplasia
- Trial name
- NCT02951130
- Testing
- Milrinone
- Where
- 19 sites in United States
- Volunteers
- 66 people
- Sponsor
- NICHD Neonatal Research Network
Dyslexia
Reading Problems in Children Living in Urban Areas
The first line of defense against reading disabilities is good classroom reading instruction. This study describes how characteristics of students, teachers, and instruction relate to academic achievement in inner-city…
- Trial name
- NCT00065832
- Testing
- Reading Instruction
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Diffuse Intrinsic Pontine Glioma
Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses
Prospective, non-blinded, randomised two cohorts study on the efficacy of two different radiotherapy schedule for DIPG by using the same concomitant and post-radiotherapy systemic treatment.
- Trial name
- DIPG (NCT03620032)
- Testing
- Nimotuzumab, Vinorelbine, Radiotherapy
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Prematurity; Extreme, Cerebral Circulatory Failure
Sonographic QUantification of Venous Circulation In the Preterm Brain
The aim of the study is to develop an accessible, reproducible ultrasound tool for objective clinical measurement of brain circulation in preterm infants in order to identify infants being at risk for preterm brain injury at an…
- Conditions
- Prematurity; Extreme, Cerebral Circulatory Failure, Intraventricular Hemorrhage, Periventricular Leukomalacia
- Trial name
- SQUIB (NCT04535375)
- Testing
- Doppler Ultrasound of venous cerebral circulation
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- Universitair Ziekenhuis Brussel
Sleep Disordered Breathing
Sleep Disordered Breathing, Adenotonsillectomy, Cognition and Pre-school Age Children
Sleep disorder breathing (SDB) is a condition affecting 10% of children aged 2-6 years. It is a combination of snoring most nights during sleep, patchy sleep, short periods of stopping breathing (apnoea) and usually big tonsils.
- Trial name
- NCT02945306
- Testing
- Adenotonsillectomy, Watchful waiting with supportive care
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Restless Legs Syndrome
Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS)
Study to determine the pharmacokinetics (PK) of pramipexole (PPX) after administration of a single dose orally (p.o.) in pediatric patients with the diagnosis of RLS
- Trial name
- NCT02231918
- Testing
- MIRAPEX® - low, MIRAPEX® - medium, MIRAPEX® - high
- Volunteers
- 26 people
- Sponsor
- Boehringer Ingelheim
Physical Activity, Eating Behavior
"Escola em Ação" (School in Action)
Background: The health promotion actions carried out in the school environment have positive effects on reducing risk factors for chronic diseases in adolescents.
- Conditions
- Physical Activity, Eating Behavior, Sedentary Lifestyle, Adolescent Behavior
- Trial name
- EA (NCT03153176)
- Testing
- Training, Individual level, Organizational level
- Where
- Brazil
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Sleep Apnea, Obstructive, Hypotonia
Pilot Study of a Self-Supporting Nasopharyngeal Airway in Hypotonia
Children with hypotonic upper airway obstruction have a high prevalence of severe obstructive sleep apnea, which if not treated has significant clinical consequence.
- Conditions
- Sleep Apnea, Obstructive, Hypotonia, Child, Only
- Trial name
- ssNPA (NCT04846400)
- Testing
- ssNPA
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Pulp Necrosis, Apexification
Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth
This study was conducted to evaluate the effect of the use of apical matrix, with Mineral Trioxide Aggregate (MTA) or calcium hydroxide Ca(OH)2 Apexification on apical healing and calcific barrier formation of immature teeth with…
- Trial name
- NCT03849222
- Testing
- Apexification, MTA, Ca(OH)2
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Running
Plyometric Exercises During the Winter Pre-season in Sprinters
Background. Plyometric training is an effective strategy to improve power and performance in sprint-based sports; however, evidence regarding its actual effects in athletes during the winter season and its potential influence on…
- Trial name
- NCT07488000
- Testing
- Plyometric training, Training without plyometric exercises
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Sleep Disordered Breathing, Obstructive Sleep Apnea
The Natural History and Outcome of Sleep Disordered Breathing in Children
Sleep-disordered breathing in children is characterized by recurrent events of partial or complete upper airway obstruction during sleep, resulting in disruption of normal gas exchange (intermittent hypoxia and hypercapnia) and…
- Trial name
- NCT02043353
- Where
- Israel
- Volunteers
- 2,856 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Obstructive Sleep Apnea, Balance
Functional Assessment and Sleep Apnea in Obese Children and Adolescents
Childhood obesity increases significantly, and determines several complications in childhood and adulthood, and the worldwide prevalence of childhood obesity has shown a rapid increase in recent decades.
- Conditions
- Obstructive Sleep Apnea, Balance, Obesity, Childhood
- Trial name
- NCT05563311
- Testing
- Exercise on High-intensity interval training
- Where
- Brazil
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Brain and Central Nervous System Tumors
Paclitaxel Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00031577
- Testing
- paclitaxel, radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Children's Hospital of Philadelphia
Macular Hole
Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery
The purpose of this study is to determine the effects of two different internal limiting membrane (ILM) peeling area on anatomical closure outcomes after macular hole surgery measured by optical coherence tomography (OCT).
- Trial name
- NCT02930369
- Testing
- ILM peeling surgery
- Volunteers
- 128 people
- Sponsor
- Peking University People's Hospital
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