Clinical trials: Internal Disorders
Obstructive Sleep Apnea
A Research Study for Children About Heart Changes and Obstructive Sleep Apnea (OSA)
In this research study the investigators want to learn more about the risk of developing blood vessel and heart disease from night-time sleep apnea.
- Trial name
- NCT01837459
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism Spectrum Disorder, Chronic Insomnia
Targeting Sleep in Kids With Autism Spectrum Disorder
Children with Autism Spectrum Disorder (ASD) and insomnia, and their parent(s) will undergo 8 sessions of Cognitive Behavioral Therapy designed for Children with Chronic Insomnia and ASD (CBT-CI-A).
- Trial name
- NCT02755051
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Sleep Apnea, Nasal Obstruction
Turbinate Cauterization in Pediatric Patients With Nasal Obstruction
patients will be placed in 2 groups, with or without turbinate cautery ( a surgical method to reduce the size of the skin covered bones in the nose), at the time of adenoidectomy and tonsillectomy.
- Trial name
- NCT01695967
- Testing
- turbinate cauterization
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Eastern Virginia Medical School
RLS
An Extension Study to Evaluate the Efficacy and Safety of HORIZANT in Adolescents With Moderate-to-Severe Primary RLS
The objectives of the trial are to evaluate the long-term efficacy and safety of HORIZANT (Gabapentin Enacarbil) 600 mg daily, for the treatment of RLS in adolescents (13 to 17 years of age) diagnosed with moderate-to-severe…
- Trial name
- RLS (NCT02633683)
- Testing
- HORIZANT 600 mg
- Where
- 11 sites in United States
- Volunteers
- 144 people
- Sponsor
- XenoPort, Inc.
Dystonia
Efficacy and Safety of DBS of the GPi in Patients With Primary Generalized and Segmental Dystonia
The purpose of this study is to evaluate the efficacy and safety of bilateral deep brain stimulation of the internal globus pallidus for treating idiopathic generalized or severe segmental dystonia.
- Trial name
- NCT00142259
- Testing
- Deep brain stimulation of the internal globus pallidus
- Where
- 8 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- German Parkinson Study Group (GPS)
Chronic Respiratory Failure
Database of Patients Treated With Respiratory Support
An observatory of patients registered in 22 local homecare associations in France, for respiratory diseases, with annual data update.
- Trial name
- observatory (NCT01181869)
- Testing
- oxygen
- Where
- France
- Volunteers
- 120,000 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Obstructive Sleep Apnea Syndrome
Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children
The aim of the project is to evaluate whether therapy with leukotriene may be a valid therapeutic approach in children with adenotonsillar hypertrophy and with mild and moderate obstructive sleep apnea syndrome (OSAS) and to…
- Trial name
- SB-OSAS (NCT00912171)
- Testing
- budesonide (Aircort 50 nasal spray), montelukast (Singulair)
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Bologna
Insomnia Chronic, Autism Spectrum Disorder
Targeting Insomnia in School Aged Children With Autism Spectrum Disorder
Children with Autism Spectrum Disorder (ASD) and insomnia, and their parent(s) will undergo 4 sessions of behavioral therapy for sleep problems followed by 4 bimonthly booster sessions.
- Trial name
- RECHArge (NCT04545606)
- Testing
- In-Person CBT for insomnia in children with autism, Remote CBT for insomnia in children with autism, Remote sleep hygiene and related education (SHARE) for insomnia in children with autism
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Missouri-Columbia
Dysbiosis
Effect of Peanut Butter on Gut and Metabolic Health
The goal of this is parallel arm, randomized clinical trial is to learn and understand the effect of daily smooth peanut butter consumption on gut and metabolic health of children age 6-13.
- Trial name
- NCT06916936
- Testing
- Creamy Richards 100% Peanuts! Creamy Natural Peanut Butter, Cadbury Milk Chocolate Spread
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Iron Deficiency, Restless Leg Syndrome
Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome
A double-blind randomized controlled trial comparing iron plus vitamin C plus probiotic (lactobacillus plantarum 299) to iron plus vitamin C plus placebo in correcting the iron deficiency in children with Restless leg syndrome…
- Trial name
- NCT01617044
- Testing
- Probiotics
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Sleep Related Breathing Disorder, Upper Airway Resistance Syndrome
Inferior Turbinate Reduction in Pediatric Population Failing Surgery for Sleep Disordered Breathing
This study will examine whether treatment of inferior turbinates in patients with continued symptoms of obstructive sleep apnea, sleep related breathing disorder, snoring, disturbed sleeping, open mouth breathing, and upper…
- Conditions
- Sleep Related Breathing Disorder, Upper Airway Resistance Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT00936494
- Testing
- Cold ablation inferior turbinate reduction
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Sleep Initiation and Maintenance Disorders, Pregnancy
A Study to Assess the Pregnancy Outcome in Women Exposed to Dayvigo® During Pregnancy Compared to an Unexposed Control Population
The primary purpose of the study is to compare the occurrence of major congenital malformations (MCMs) among live births between women with insomnia who are exposed to Dayvigo during the 1st trimester of pregnancy and women with…
- Trial name
- NCT06744673
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 861 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Narcolepsy, Idiopathic Hypersomnia
Anesthetic Management of Patients With Chronic Sleep Disorders
The aim of this study is to describe and compare the anaesthesia history and possible problems encountered in 3 groups of patients with 3 chronic sleep diseases: narcolepsy, idiopathic hypersomnia, and restless legs syndrome…
- Conditions
- Narcolepsy, Idiopathic Hypersomnia, Restless Legs Syndrome
- Trial name
- ANEST-SLEEP (NCT04827329)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Montpellier
Tonsillectomy
Muscle Relaxation for Pediatric Adenotonsillectomy
The goal of this clinical trial is to compare general anesthesia with muscle relaxation and reversal of the relaxation at the end of surgery or without muscle relaxation in high-risk children having adenotonsillectomy surgery.
- Trial name
- NCT06225466
- Testing
- Rocuronium, Sugammadex, Anesthesia without neuromuscular blockade
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- University of Texas Southwestern Medical Center
Narcolepsy
Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy
Primary Objectives: The primary objectives of the study are to determine the effectiveness of PROVIGIL treatment, compared to placebo treatment, in children and adolescents with excessive sleepiness (ES) associated with…
- Trial name
- NCT00107796
- Testing
- Modafinil
- Where
- 73 sites in United States, Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cephalon
Insomnia, Depression
Development of an Insomnia Treatment for Depressed Adolescents
Major depressive disorder (MDD) occurs at least 11% of adolescents and approximately 53-90% of those adolescents have insomnia. If left untreated, insomnia increases the risk of relapse and recurrence of depressive episodes…
- Trial name
- NCT02163564
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Michigan
Preterm Birth
The Contribution of Internal Maternal Resources to Creation of Motherhood. Comparison Among Mothers to Twins and Singleton
Delivery of twins or preterm infant is a very stressful episode to mothers. The purpose of this study is to characterize maternal psychological resources in dealing with this situation and compare it to mothers giving birth to…
- Trial name
- NCT00353236
- Where
- Israel
- Sponsor
- Sheba Medical Center
Insomnia
Gabapentin's Effects on Insomnia in Patients With Recent Concussion
In this open-label, pilot study the investigators will be assessing gabapentin's effects on insomnia and other concussion-related symptoms in patients with a recent concussion experiencing insomnia.
- Trial name
- NCT01421264
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- State University of New York at Buffalo
Congenital Diaphragmatic Hernia, Pulmonary Hypertension
A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)
Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 3000 US live births, similar to the incidence seen within the Utah Birth Defects cohort.
- Trial name
- NCT05201144
- Testing
- Sildenafil Oral Suspension
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Insomnia, Mental Health Issue
Investigating a Sleep Intervention for Adolescents Attending Mental Health Services
The overall objectives of the study are to: 1. To assess the feasibility of delivering the Strathclyde Sleep Intervention to adolescents with co-morbid insomnia and mental health attending a mental health services The following…
- Trial name
- NCT05870228
- Testing
- Strathclyde Sleep Intervention
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Stephanie McCrory
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