Clinical trials: Internal Disorders
Obstructive Sleep Apnea
Clinical Characteristics and Molecular Mechanism of Patients With Obstructive Sleep Apnea
To clarify the clinical features of patients with obstructive sleep apnea; To construct a multi-omics database of patients with obstructive sleep apnea, and compare the effects of different degrees of sleep apnea on prognosis…
- Trial name
- NCT07277608
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Temporomandibular Joint Dysfunction, Pain
Efficacy of Arthrocentesis by Injection of Ringer With or Without Corticosteroid in Treatment of Internal Derangement
The study aims to evaluate effectiveness of ringer injection with or without corticosteroid during arthrocentesis of the temporomandibular joint in the treatment of internal derangement of the temporomandibular joint (TMJ).
- Conditions
- Temporomandibular Joint Dysfunction, Pain, Arthrocentesis
- Trial name
- NCT01958879
- Testing
- ringer with corticosteroid, ringer without corticosteroid
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Sleep Apnea, Obstructive
Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea
The purpose of this research study is to examine the effects of two commonly used anesthetic drugs, dexmedetomidine and propofol, have on the shape and muscle tone of the upper airway in children, adolescents, and young adults…
- Trial name
- NCT01344759
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Taking Benzodiazepines for Any Reason for 3 Months, Benzodiazepine Dependence
Promoting Benzodiazepine Cessation Through an Electronically-delivered Patient Self-management Intervention
Benzodiazepines (e.g., Ativan, Xanax) are widely prescribed medications that are used mainly to treat anxiety and sleeping difficulties.
- Trial name
- EMPOWER-ED (NCT04572750)
- Testing
- EMPOWER-ED
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Pes Planus
Foot Muscle Strengthening Exercises for Pes Planovalgus
Pes planovalgus is a common foot condition affecting the child population. It is characterized by the partial or complete collapse of the medial longitudinal arch with rearfoot eversion and forefoot abduction, which is associated…
- Trial name
- NCT06548750
- Testing
- Intrinsic and Ectrinsic Exercise, Intrinsic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
Myogenic Temporomandibular Joint Disorders, Internal Derangement of the Tempromandibular Joint
Adjustment Technique for Occlusal Stabilizing Splint
This study aims to clarify the technique of occlusal stabilizing splint adjustment then to assess the overall clinical outcomes and patient satisfaction.
- Conditions
- Myogenic Temporomandibular Joint Disorders, Internal Derangement of the Tempromandibular Joint, Temporomandibular Disorders (TMDs), Temporomandibular Joint Disc Displacement
- Trial name
- NCT07397013
- Testing
- Stabilizing Splint(3-point of Contact), Stabilizing Splint (Centric and Eccentric)
- Where
- Egypt
- Volunteers
- 800 people
- Sponsor
- Mansoura University
Respiratory Depression, Obstructive Sleep Apnea
Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea
The sole objective in this study is to evaluate if routine amounts of opioids given for tonsillectomy in children have greater amounts of respiratory depression in children with documented obstructive sleep apnea when compared…
- Trial name
- NCT03938259
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Insomnia, Migraine Disorders
Intervention for Sleep and Pain in Youth: A Randomized Controlled Trial
Insomnia is a common comorbidity among adolescents with migraine. This randomized controlled clinical trial aims to determine efficacy of cognitive-behavioral therapy (CBT) for insomnia, as well as the combined effect of CBT…
- Conditions
- Insomnia, Migraine Disorders, Headache Disorders
- Trial name
- I-SPY-RCT (NCT04936321)
- Testing
- Internet-delivered CBT for Insomnia, Internet-delivered CBT for Pain Management, Internet-delivered Sleep Education
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Seattle Children's Hospital
Oncolytic Virus, Diffuse Intrinsic Pontine Glioma
Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma
This is a single-arm, single-center, drug safety assessment clinical trial with a 3+3 dose escalation design, to observe the safety, tolerability and toxicity of a novel oncolytic virus Ad-TD-nsIL12 intratumoral injection in…
- Conditions
- Oncolytic Virus, Diffuse Intrinsic Pontine Glioma, Adverse Drug Event
- Trial name
- NCT05717699
- Testing
- Ad-TD-nsIL12
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Capital Medical University
Tonsillitis, Sleep Disordered Breathing
Opioid Use, Storage, and Disposal Among Pediatric Patients After Surgery
Opioids are an important component of post-operative pain management among children, but are often prescribed in excess and rarely disposed of appropriately.
- Conditions
- Tonsillitis, Sleep Disordered Breathing, Hernia, Hydrocele
- Trial name
- NCT03575377
- Testing
- Disposal Aid
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Nationwide Children's Hospital
Vestibular Schwannoma, Inner Ear Disease
Vestibular Precision: Physiology & Pathophysiology
This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors.
- Conditions
- Vestibular Schwannoma, Inner Ear Disease, Dizziness, Neurofibromatosis 2
- Trial name
- NCT04890132
- Testing
- VOR precision training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood.
- Conditions
- Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea, Tonsillitis, Tonsil Disorder
- Trial name
- NCT05656365
- Where
- 3 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
ASD, Insomnia
A Brief Parent-based Sleep Intervention for Children With Autism Spectrum Disorder
Sleep problems are very common in children with ASD, with a prevalence rate as high as 78%, and often pose significant challenges and stress to the families.
- Trial name
- NCT05010824
- Testing
- Sleep hygiene practices and behavioural intervention
- Where
- 2 sites in Hong Kong
- Volunteers
- 75 people
- Sponsor
- The University of Hong Kong
Restless Legs Syndrome
Observational Study of Sifrol® in Patients With Primary Restless Legs Syndrome (RLS)
Study to evaluate treatment effect of pramipexole on RLS severity as measured by IRLS, CGI-I and RLS-6 and to evaluate the time needed to reach maintenance dose of Pramipexole (PPX)
- Trial name
- NCT02248142
- Testing
- Pramipexole
- Volunteers
- 1,029 people
- Sponsor
- Boehringer Ingelheim
Cryptorchidism
Transection Versus Ligation of Internal Spermatic Vessels in Laparoscopic Fowler-Stephens Orchidopexy
This is a comparative study to see the outcome of yransection versus ligation of internal spermatic vessels in first stage laparoscopic Fowler-Stephens orchidopexy for intra-abdominal testis in assisting the descent of the testis…
- Trial name
- NCT06558994
- Testing
- Transection of internal spermatic vessels in first stage laparoscopic Fowler-Stephens orchidopexy for intra-abdominal testis, Ligation of internal spermatic vessels in first stage laparoscopic Fowler-Stephens orchidopexy for intra-abdominal testis
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Assiut University
Pregnancy, High Risk, Anxiety State
The Effects of Music on the Anxiety and Sleep Quality of Pregnant Women on Bed Rest for a High-risk Pregnancy
The purpose of this study is to identify the effects of music on the anxiety and sleep quality of women with high-risk pregnancy having bed rest in the hospital in Turkey.
- Conditions
- Pregnancy, High Risk, Anxiety State, Sleep Quality
- Trial name
- NCT05316415
- Testing
- Acemaşiran Music Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Chronic Neck Pain, Disability
Association Between Neck Pain and Quality of Sleep
A prospective study to assess the association between the change in quality of sleep and the change in intensity of pain in Spanish patients seen for subacute or chronic neck pain.
- Trial name
- NCT00907049
- Where
- 2 sites in Spain
- Volunteers
- 424 people
- Sponsor
- Kovacs Foundation
Sleep Initiation and Maintenance Disorders
Single Dose Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Evaluation of Eplivanserin in Children With Insomnia
Given the potential age-related differences in safety, tolerability, pharmacokinetics, and differences in sleep architecture in young children versus adolescent versus adult, studies to identify the appropriate drug and dosage…
- Trial name
- PKiDs (NCT00913614)
- Testing
- Eplivanserin (SR46349)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Sanofi
Retinal Detachment, Surgery
Internal Limiting Membrane Flap in the Management of Retinal Detachment Due to Paracentral Retinal Breaks
To describe the technique and outcomes of using either inverted or free internal limiting membrane flap in the management of retinal detachment due to paracentral retinal breaks.
- Trial name
- NCT03707015
- Volunteers
- 9 people
- Sponsor
- San Ni Chen
Sleep Apnea, Obstructive
Effect of Adenotonsillectomy on Quality of Life in Children With Mild Obstructive Sleep Apnea
In children, enlarged adenoids and/or tonsils are the most common cause of obstructive sleep apnea (OSA), which is temporary blockage of breathing during sleep.
- Trial name
- NCT01539278
- Testing
- Adenotonsillectomy, Observation alone / no intervention
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
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