Clinical trials: Internal Disorders
Hernia, Diaphragmatic, Hypertension, Pulmonary
Chronic Sildenafil for Severe Diaphragmatic Hernia
The purpose of this study is to test if sildenafil is effective in the treatment of infants with severe congenital diaphragmatic hernia (determined by the presence of prolonged pulmonary hypertension or prolonged oxygen…
- Conditions
- Hernia, Diaphragmatic, Hypertension, Pulmonary, Hypoplasia, Pulmonary
- Trial name
- NCT00133679
- Testing
- sildenafil
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Percutaneous Internal Ring Suturing, Pain Management
Comparison of the Postoperative Analgesic Effects of RSB and CEB in Pediatric Patients Scheduled for Percutaneous Internal Ring Suturing
Inguinal hernia is one of the most common surgical pathologies in children, and the minimally invasive percutaneous internal ring suturing (PIRS) technique is widely preferred.
- Trial name
- NCT07147062
- Testing
- Rectus Sheath Block, Caudal Epidural Block
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Cough, Respiratory Tract Infections
Effect of Honey and Dextromethorphan on Nocturnal Cough and Sleep
Cough is the most common reason for an acute care doctor's visit in the United States. Cough can affect sleep for both coughing children and their parents.
- Trial name
- NCT00127686
- Testing
- Dextromethorphan, Buckwheat Honey
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Penn State University
Ondine Syndrome
Assessment of Desogestrel in Ondine Syndrome
The congenital central hypoventilation syndrome (CCHS), also known as the Ondine syndrome, is a very rare genetic disorder. In contrast with healthy people, patients do not increase breathing in response to an excess of carbon…
- Trial name
- RESPIRONDINE (NCT01243697)
- Testing
- desogestrel
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Apnea, Sleep Apnea Syndromes
Oropharyngeal Exercises and Post-Stroke Obstructive Sleep Apnea
This study evaluates the feasibility and effectiveness of an oropharyngeal exercise (O-PE) regimen in treating post-stroke obstructive sleep apnea, as an alternative therapy to continuous positive airway pressure (CPAP).
- Conditions
- Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Stroke
- Trial name
- NCT04212260
- Testing
- Oropharyngeal exercises
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sick Leave, Insomnia
Health Promoting Work Schedules: The Effect of Abolishing Quick Returns
Introduction In shift work, quick returns refer to transitions between two shifts with less than 11 hours available rest time. Twenty-three per cent of employees in European countries reported having quick returns.
- Conditions
- Sick Leave, Insomnia, Shift-Work Sleep Disorder, Psychological Distress
- Trial name
- HeWoS (NCT04693182)
- Testing
- Shift schedule without quick returns
- Where
- Norway
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Restless Legs Syndrome
Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS)
Study to determine the pharmacokinetics (PK) of pramipexole (PPX) after administration of a single dose orally (p.o.) in pediatric patients with the diagnosis of RLS
- Trial name
- NCT02231918
- Testing
- MIRAPEX® - low, MIRAPEX® - medium, MIRAPEX® - high
- Volunteers
- 26 people
- Sponsor
- Boehringer Ingelheim
Insomnia, Sleep Initiation and Maintenance Disorders
Zolpidem (Myslee) Post Marketing Study in Adolescent Patients With Insomnia - Evaluation With Polysomnography
To evaluate the efficacy of zolpidem for adolescent insomniacs with polysomnography
- Trial name
- NCT00653562
- Testing
- zolpidem
- Where
- 4 sites in Japan
- Volunteers
- 11 people
- Sponsor
- Astellas Pharma Inc
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Obstructive Sleep Apnea Syndrome
Management of Obstructive Sleep Apnea (OSA) in Children and Maxillary and Mandibular Development
Assessment of the association of maxillary expansion using a rapid palatal expansion, use of a mandibular advancement appliance (MGA™) and of a device allowing sleep in a semi-seated position (Yoobreath™) in patients with…
- Trial name
- SAOS (NCT03267927)
- Testing
- Rapid palatal expansion, MGA™ system, Yoobreath™ system
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Rennes University Hospital
Asthma, Perennial Allergic Rhinitis
Biomarkers of Cockroach Sublingual Immunotherapy 2
This trial is a follow-up study of the ICAC-12 Phase I/II trial (NCT00829985), and is designed to study biomarkers of the immune response to allergen immunotherapy and the safety of this therapy in a pediatric population.
- Trial name
- BioCSI-2 (NCT01380327)
- Testing
- Cockroach Sublingual Immunotherapy (SLIT) - Low Dose, Cockroach Sublingual Immunotherapy (SLIT) - High Dose
- Where
- 5 sites in United States
- Volunteers
- 99 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
ADHD, Sleep Problems
A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep
The goal of this clinical trial is to learn if iron supplementation works to restless sleep in youth with ADHD. A second goal is to learn if iron supplementation helps to ease ADHD symptoms.
- Trial name
- NCT07061470
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Epilepsy, Insomnia
Trial of Melatonin to Improve Sleep in Children With Epilepsy and Neurodevelopmental Disabilities
The purpose of the study is to evaluate the safety and efficacy of oral melatonin in improving sleep continuity in children with epilepsy and neurodevelopmental delay who have chronic insomnia by comparing Fast Release Melatonin…
- Conditions
- Epilepsy, Insomnia, Developmental Disability
- Trial name
- NCT01161108
- Testing
- Fast Release Melatonin (FR MLT), Timed Release Melatonin (TR MLT)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- The Hospital for Sick Children
Depressive Symptoms, Anxiety
Culturally Adapted iCBT for Arabic-speaking Refugee and Migrant Youth With Common Mental Health Problems
The aim of the current study is to explore whether culturally adapted internet-based cognitive behavioral therapy is effective in reducing the symptoms of various common mental health problems among Arabic-speaking refugee and…
- Conditions
- Depressive Symptoms, Anxiety, Insomnia, Grief
- Trial name
- RAHA (NCT06102096)
- Testing
- Culturally Adapted iCBT
- Where
- Sweden
- Volunteers
- 125 people
- Sponsor
- Karolinska Institutet
Obstructive Sleep Apnea
To Study the Impact of CPAP on Gait Parameters in OSA Patients
To study the impact of CPAP therapy on gait in patients with obstructive sleep apnea syndrome.
- Trial name
- OSA_Gait (NCT02061046)
- Testing
- CPAP therapy
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University Hospital, Geneva
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
Multi-disciplinary Diagnosis and Treatment Process and Evaluation System for Children With Sleep Disordered Breathing and Malocclusion
The aim of this study is to compare the efficacy and safety of drug therapy, tonsillar adenoidectomy only, orthodontic treatment only and tonsillar adenoidectomy plus orthodontic treatment in children with obstructive sleep apnea…
- Trial name
- NCT03451318
- Testing
- Mometasone Furoate Nasal Spray, tonsillar adenoidectomy, Maxillary expander plus Twin-Block
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Stomotological Hospital
Port-A-Cath
Comparison of Outcomes of Right Internal Jugular Port Implantation in Patients With Right Versus Left Breast Cancer Undergoing Chemotherapy
Chemotherapy is an essential component of breast cancer treatment. Frequent intravenous injections may lead to phlebitis and limited venous access, therefore implantable venous ports are increasingly used.
- Trial name
- NCT07197320
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Golestan University of Medical sciences
Recurrent Shoulder Dislocations
Arthroscopic Rotator Interval Closure in Shoulder Instability Repair
Study Title: Arthroscopic rotator interval closure in shoulder instability repair - a prospective study Objective: To evaluate the effect of arthroscopic rotator interval closure (ARIC) on patients with recurrent shoulder…
- Trial name
- NCT00901797
- Testing
- Arthroscopic Bankart repair, ABR+ARIC
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Autism Spectrum Disorder, Insomnia
Iron Treatment of Sleep Disorders in Children With Autism Spectrum Disorder
Autism Spectrum Disorders (ASD) are characterized by difficulties in language, social communication, and repetitive and restricted behaviors. ASD affects as many as 1 in 90-150 children.
- Trial name
- NCT01745497
- Testing
- Ferrous sulfate
- Where
- 4 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea (OSA), Orofacial Myofunctional Disorders
Oromyofunctional Therapy: a Rehabilitation Program for OSA in Children With Down Syndrome and Prader-Willi Syndrome
Obstructive sleep apnea (OSA) is a prevalent medical condition with important implications for overall health and quality of life in both children. Therefore, it is important to treat OSA early and effectively.
- Trial name
- OROFIT-P (NCT07122505)
- Testing
- Orofacial myofunctional therapy
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Ghent
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