Clinical trials: Interventional Study
Noninvasive Positive Pressure Ventilation, High Flow Nasal Cannula
A Multicentered Study on Efficiency of Noninvasive Ventilation Procedures
Noninvasive ventilation (NIV) is an alternative form of ventilatory support in critical care encompassing different modes of ventilation such as continuous positive airway pressure (CPAP), bilevel positive airway pressure (BiPAP)…
- Conditions
- Noninvasive Positive Pressure Ventilation, High Flow Nasal Cannula, Failure, Respiratory
- Trial name
- SAFE-NIV (NCT03066934)
- Testing
- noninvasive ventilation respiratory support
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 352 people
- Sponsor
- Akdeniz University
Stroke, Attention
Enhancing Attention and Processing Speed Through Home-based Music Rehabilitation Program After Stroke in Malaysia
Stroke often leads to significant cognitive impairment, impacting quality of life. While existing rehabilitation options exist, there's a need for innovative, accessible, and patient-centered solutions.
- Conditions
- Stroke, Attention, Rehabilitation Program, Music Intervention
- Trial name
- HMRPAS (NCT07522463)
- Testing
- Musical Home-based Rehabilitation Program, Control group (standard care)
- Where
- Malaysia
- Volunteers
- 44 people
- Sponsor
- University of Malaya
Insomnia
Effectiveness of a Guided Self-help Intervention for Improving Sleep in University Students
This randomized controlled trials aims to assess the effectiveness of an online guided self-help intervention ('i-Sleep \& BioClock') based on CBTi principles for university students' sleep problems.
- Trial name
- NCT06023693
- Testing
- i-Sleep & BioClock, Online Psychoeducation
- Where
- Netherlands
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Insomnia, Psychosis
Implementation of Digital CBT for Insomnia in First Episode Psychosis
This study uses mixed methods to investigate the implementation of digital cognitive behavioural therapy for insomnia (Sleepio) in a first episode of psychosis service (FEP).
- Conditions
- Insomnia, Psychosis, First Episode Psychosis
- Trial name
- NCT05050201
- Testing
- Sleepio
- Where
- 2 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- NHS Greater Glasgow and Clyde
Coronary Artery Disease, Coronary Angioplasty
Atorvastatin Pre-Treatment Influences the Risk of Percutaneous Coronary Intervention (PCI) Study 2
This study investigates potential protective effect of atorvastatin pre-treatment in patient with stable coronary artery disease undergoing percutaneous coronary intervention (PCI) on chronic statin therapy.
- Trial name
- TIPS-2 (NCT01058057)
- Testing
- atorvastatin
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital, Motol
ENT Disorder, Nasal Procedures
Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution and NUMBRINO™ Nasal Solution
The purpose of this study is to assess the pharmacokinetic (PK) properties, safety and tolerability following a single dose administration of GOPRELTO® or NUMBRINO™ as an anesthetic for diagnostic procedures and surgeries on or…
- Conditions
- ENT Disorder, Nasal Procedures, Nasal Anesthesia, Nasal Mucosa Surgery
- Trial name
- NCT04792034
- Testing
- Cocaine Hydrochloride Nasal Solution
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- LXO Ireland
Autism, Autism Spectrum Disorder (ASD)
ScanBrit Dietary Intervention in Autism
A growing body of research indicates that dietary intervention excluding foods containing the proteins, gluten and casein, from the diet of children diagnosed with an autism spectrum disorder (ASD) may have a positive effect on…
- Trial name
- ScanBrit (NCT00614198)
- Testing
- Gluten- and casein-free diet
- Volunteers
- 72 people
- Sponsor
- Center for Autisme, Denmark
CP (Cerebral Palsy), Robotic Exoskeleton
Study Aims to Compare the Effect of Robotic-assisted Gait Training and Conventional Treadmill Training on Postural Stability in Ambulatory Children With Cerebral Palsy.
The aim of this study is to explore the impact of gait training with a robotic device versus treadmill training on enhancing postural stability and walking capabilities in children with cerebral palsy (CP).
- Conditions
- CP (Cerebral Palsy), Robotic Exoskeleton, Treadmill Locomotor-based Training, Postural Stability
- Trial name
- NCT06719271
- Testing
- Participants this group will receive gait training in robotic assisted gait training (RAGT) three times per week for eight weeks, Body Weight Supported Treadmill Training
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Saud University
Epidermolysis Bullosa
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Epidermolysis Bullosa (Phase III)
The aim of this clinical trial is to investigate the safety and efficacy of allo-APZ2-OTS administered intravenously to subjects with recessive dystrophic epidermolysis bullosa (RDEB) compared to placebo.
- Trial name
- NCT05838092
- Testing
- allo-APZ2-OTS
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- RHEACELL GmbH & Co. KG
Eating Disorders
Implementation of a Waitlist Intervention and Clinical Care Pathway for Families Awaiting at Eating Disorders Program
The COVID-19 pandemic has resulted in several challenges in service delivery for the eating disorders program at McMaster Children's Hospital.
- Trial name
- WICFAS (NCT04812899)
- Testing
- Parental guided self-help version of FBT-pre-recorded videos and readings from the book
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Pain Management
Non-Pharmacological Nursing Pain Management for Preterm Infants
A randomized controlled trial will be conducted to examine the effect of non-pharmacological nursing pain management strategies in alleviating pain among preterm infants.
- Trial name
- NCT05947877
- Testing
- Non-pharmacological pain management strategies
- Where
- Iraq
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Acute Coronary Syndrome (ACS)
PROSPECT II & PROSPECT ABSORB - an Integrated Natural History Study and Randomized Trial.
The present study has two components, an overall prospective observational study using multimodality imaging (PROSPECT II) that will examine the natural history of patients with unstable atherosclerotic coronary artery disease…
- Trial name
- P2 (NCT02171065)
- Testing
- ABSORB BVS
- Where
- Sweden
- Volunteers
- 902 people
- Sponsor
- Uppsala University
Psoriasis
Oral Psoriasis Treatment Adherence and Intervention Study
Response to psoriasis treatment is variable in large part because of poor adherence treatments. Studies using electronic monitors have assessed adherence to topical and injectable psoriasis treatments and to biologics, yielding…
- Trial name
- NCT02850900
- Testing
- Internet Survey
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Wake Forest University Health Sciences
Infant, Premature, Diseases, Brain White Matter Disease Periventricular
Initial Efficacy Study of Supporting Play, Exploration, & Early Development Intervention
The primary aims of this randomized controlled trial are to evaluate efficacy potential of SPEEDI at enhancing reaching and play based problem solving compared to infants receiving usual care.
- Trial name
- SPEEDI (NCT02153736)
- Testing
- SPEEDI Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Virginia Commonwealth University
Acromioclavicular Joint, Dislocation
A Prospective, Randomised Long-term Follow-up of Operative Versus Non-operative Treatment of Gr. 3 Acromioclavicular Dislocation
The purpose of this study is to compare the long-term clinical and radiological results of operative and conservative treatment of Tossy type 3 acromio-clavicular dislocation.
- Conditions
- Acromioclavicular Joint, Dislocation, Surgical Procedures, Operative
- Trial name
- NCT00840593
- Testing
- Non-surgical group, Surgical group
- Where
- Finland
- Volunteers
- 39 people
- Sponsor
- Kuopio University Hospital
Aplastic Anemia (AA)
Effectiveness of Early Intervention in Transfusion Independent Aplastic Anemia: a Retrospective Medical Claims Database Study
This was a retrospective non-interventional cohort study with secondary use of data from the Medical Data Vision (MDV) hospital-based database to evaluate the effectiveness of early drug intervention in preventing transfusion…
- Trial name
- NCT06669221
- Where
- Japan
- Volunteers
- 1,603 people
- Sponsor
- Novartis Pharmaceuticals
Alcohol Misuse, Drug Misuse
Family and Social Intervention for Young People
Research evidence shows that there is a high prevalence of substance use among young people in the UK. Early onset and high levels of use are associated with a range of negative outcomes, including increased risk of later…
- Trial name
- YSBNT (NCT02399865)
- Testing
- Youth Social Behaviour and Network Therapy
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Occupational Stress
Effects of an Exercise Snack Intervention on Employee Health and Work Performance
To create brief exercise videos addressing physical discomfort, fitness goals, and movement skills. To design personalized exercise menus to enhance staff adherence.
- Trial name
- NCT07126444
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Self-Harm, Suicidal
Co-Producing LGBTQ-Affirmative DBT Protocols.
Aims: 1. To co-produce new intervention parts that meet the needs of LGBTQ+ people at risk of self-harm or suicidal thoughts, with LGBTQ+ people and DBT therapists.
- Conditions
- Self-Harm, Suicidal, Emotional Dysregulation
- Trial name
- NCT06966193
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King's College London
Pelvic Girdle Pain
Pelvic Girdle Pain in a Pregnant Population in Western Norway.
The objectives in this study are 1. to explore the incidence and cumulative prevalence of pelvic girdle pain (PGP) and its subgroups in a prospective longitudinal study during pregnancy, from 18 weeks until 6 weeks after…
- Trial name
- NCT01098136
- Testing
- Chiropractic, Conventional medical intervention, Conventional and alternative intervention
- Where
- Norway
- Volunteers
- 650 people
- Sponsor
- Helse Stavanger HF
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