Clinical trials: Intestinal Flora
Cardiometabolic Risk
Milk Polar Lipids Consumption, Lipid Metabolism, and Inflammation in Menopausal Women
Polar lipids have a specific chemical structure: they are an essential component of human cell membranes, play a major role in the nervous system and also influence the metabolic pathways including the cholesterol metabolism.
- Trial name
- VALOBAB-C (NCT02099032)
- Testing
- 3g milk polar lipid fortified cheese consumption, 5g milk polar lipid fortified cheese consumption, Unfortified cheese product consumption
- Where
- 2 sites in France
- Volunteers
- 59 people
- Sponsor
- Hospices Civils de Lyon
Anxiety, Abdominal Pain
The Probiotic Study: Using Bacteria to Calm Your Mind
The investigators seek to conduct the first open-label trial of probiotics in young children to reduce their anxiety and abdominal pain.
- Trial name
- NCT02711800
- Testing
- Lactobacillus rhamnosus
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Nancy Zucker
Eczema, Atopic Dermatitis
Studies of Skin Microbes in Healthy People and in People With Skin Conditions
This study will examine microbes (e.g., bacteria, fungi, viruses) that live on human skin and how microbes contribute to health and disease.
- Trial name
- NCT00605878
- Where
- United States
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Type 1 Diabetes
The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
The primary aim of this pilot study is to test whether gluten-free diet (GFD) instituted in children shortly after onset of Type 1 Diabetes (T1D) can decelerate the decline in beta cell function as compared to age matched…
- Trial name
- NCT02867436
- Testing
- Gluten-free diet
- Where
- 2 sites in Czechia
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Obesity, Growth
Essential Fatty Acids During Complementary Feeding
The objective of this intervention study is to examine the effect of n-3 LCPUFA on growth and body composition, intestinal health and microbiotic composition, immune function and risk markers for later diseases in 9-18 months old…
- Conditions
- Obesity, Growth, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- EFiON (NCT00631046)
- Testing
- Fish Oil, Sunflower Oil
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Early Life Adversity, Microbiome, Human
Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity
The goal of this observational study is to learn about the effects of early-life adversity (ELA) on the composition of children's microbiome and on their psychosocial functioning.
- Conditions
- Early Life Adversity, Microbiome, Human, Anxiety Symptoms, Depressive Symptoms
- Trial name
- BellyBrain (NCT06922773)
- Testing
- Completion of questionnaires; child psychiatric screening; faecal sample analysis
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
Graft Vs Host Disease
Alterations in Intestinal Microbiota, Metabolites, and Immune Cells in Allo-HSCT
This research project delves into the critical role of gut immunity in the occurrence and progression of acute graft-versus-host disease (aGVHD) post allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- NCT06143501
- Testing
- Blood Sample, Stool Sample, Urine Sample
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Temperament, Sleep
GUTLINK4KIDS Intervention
This study aims to investigate the chronic effects of prebiotic consumption on cognitive, behavioural and gut microbiome outcomes in children aged 3-5 years.
- Conditions
- Temperament, Sleep, Cognition, Emotion Regulation
- Trial name
- GUTLINK4KIDS (NCT07401212)
- Testing
- Prebiotic powder
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Reading
Autism Spectrum Disorder
Gut Microbiome Characteristics and Neurodevelopmental Functioning in Children With Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that affects communication, behavior, sensory processing, and daily functioning.
- Trial name
- GAIN-ASD (NCT07646808)
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Saveetha University
Childhood Obesity, Childhood Overweight
Assessment of the Effects of Synbiotic on Gut Microbiota Composition in Scholars With Overweight
This study was a randomized, double-blind controlled protocol in children overweight aged 6-11 years. This study aimed to evaluate the effect of consuming fermented milk products containing Lactobacillus casei strain Shirota…
- Trial name
- NCT05423015
- Testing
- Lactobacillus casei strain Shirota, Lactobacillus casei strain Shirota plus inulin, Lactobacillus casei strain Shirota plus fructans from A. salmiana
- Where
- Mexico
- Volunteers
- 37 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Atopic Dermatitis (Eczema), Atopic Dermatitis, Probiotics
Prebiotic Effects of Mulberry Fruit in Children and Adolescents With Atopic Dermatitis
This project proposes a randomized controlled human study to explore the prebiotic effects of consuming mulberry juice on atopic dermatitis in children and adolescents.
- Trial name
- NCT06636240
- Testing
- Mulberry fruit juice, Mometasone furoate 0.1% cream
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Liver Cirrhosis
Compositional Shift of Gut Microbiome According to the Complications in Patients With Liver Cirrhosis
Change in gut microbiome is closely associated with liver cirrhosis diseases initiation, progression, establishment, and severity.
- Trial name
- NCT05786755
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Clinical Infection, Microbial Colonization
Effect of Gut Microbiota and Fecal Inflammatory Marker on Childhood Gastroenteritis
Childhood gastroenteritis establishes gastrointestinal disease and increase the economic burden, and the pediatric population is especially vulnerable to these gastrointestinal infections.
- Conditions
- Clinical Infection, Microbial Colonization, Gastroenteritis, Inflammatory Response
- Trial name
- NCT03856138
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Systemic Lupus Erythematosus (SLE)
Mediterranean Diet and Gut Microbiota in Children With Systemic Lupus Erythematosus
The goal of this clinical trial is to learn if a Mediterranean diet can improve gut microbiota, disease activity, and nutrition in children with systemic lupus erythematosus (SLE).
- Trial name
- NCT07555626
- Testing
- Mediterranean Diet-Based Individual Nutrition Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Gut Microbiota
Westlake Gut Microbiome Study
The Westlake Gut Microbiome study is a prospective cohort study. This project aims to characterize the gut microbiome among Chinese populations from different regions of China, and explore the relationships between gut microbiota…
- Trial name
- NCT04435548
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Severe Acute Malnutrition
Microbiota Directed Food for Children With Severe Acute Malnutrition
Severe acute malnutrition (SAM) refers to a condition characterized by a significant deficit in weight-for-length measurements in children aged 6 to 59 months.
- Trial name
- NCT06308848
- Testing
- Microbiota-Directed Food, Ready-to-Use Therapeutic Food
- Where
- Bangladesh
- Volunteers
- 256 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Type 1 Diabetes
Intervention on New Onset-T1D Children
A pilot proof of concept clinical trial will be performed to demonstrate the restoration of gut barrier integrity by administration of beneficial anti-inflammatory gut microbial strains (Lactobacilli-enriched Vivomixx® probiotic)…
- Trial name
- NCT05767450
- Testing
- Probiotic Vivomixx®
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Osteoporosis
Dose Effects of SCF on Calcium Metabolism and GI Microflora in Adolescents
Soluble corn fiber (SCF) has been shown to enhance calcium utilization and bone properties in rats and in adolescent boys and girls.
- Trial name
- NCT01660503
- Testing
- 0 grams SCF, 10 grams SCF, 20 grams SCF
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Purdue University
Genotype, Metabotype and Dietary Habits
Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.
The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort…
- Trial name
- PolyMicroBio (NCT03318042)
- Testing
- Walnuts, Pomegranate juice
- Where
- Spain
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Microbial Colonization, Antibiotic Side Effect
Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome
In this study, investigators seek to determine whether the timing of antibiotics given to mothers during an elective C-section affects the composition of their infant's gut microbiome.
- Conditions
- Microbial Colonization, Antibiotic Side Effect, Cesarean Section Complications
- Trial name
- CSBabyBiome (NCT06030713)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen