Clinical trials: Intestinal Flora
Genotype, Metabotype and Dietary Habits
Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.
The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort…
- Trial name
- PolyMicroBio (NCT03318042)
- Testing
- Walnuts, Pomegranate juice
- Where
- Spain
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Rotavirus Infections, Reaction - Vaccine Nos
Does the Fecal Microbiome Influence Rotarix Immunogenicity
This is a proposal for a nested case-control study within an ongoing rotavirus vaccine immunogenicity clinical trial Karachi, Pakistan.
- Conditions
- Rotavirus Infections, Reaction - Vaccine Nos, Intestinal Bacteria Flora Disturbance
- Trial name
- NCT02220439
- Volunteers
- 76 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Stunting of Growth, Chronic Malnutrition
Pilot Study of a Modified Therapeutic Food Compared With a Standard Nutrient Supplement in Young Children in Rural Guatemala
The goal of this clinical trial is to learn whether a modified food supplement is acceptable and well tolerated by children aged 12 to 24 months with mild-to-moderate stunting in rural Guatemala.
- Trial name
- NCT07804667
- Testing
- Modified Therapeutic Food Formulation, Nutri Listo SQ-LNS
- Where
- Guatemala
- Volunteers
- 36 people
- Sponsor
- Wuqu' Kawoq, Maya Health Alliance
Microbial Colonization
The Influence of Infant Feeding Type on Preterm Infant's Intestinal Microbiome
This study aims to examine the factors associated with preterm infant's intestinal microbiota depending on feeding type (breast milk or preterm formula)
- Trial name
- NCT04972214
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- CHA University
Gut Microbiome
User Testing of the Evivo Screening Test
The study is an evaluation of the Evivo Screening Test's ability to differentiate between high and low levels of Bifidobacterium in infant stool specimens.
- Trial name
- NCT03601936
- Testing
- Evivo Infant Gut Bifidobacterium Screening Test
- Where
- 5 sites in United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Evolve BioSystems, Inc.
Acute Lymphoblastic Leukemia
The Association Between Gut Microbiome Composition Signature and Cancer-related Symptoms in Children With Acute Lymphoblastic Leukemia
This study is a prospective longitudinal investigation. Data on disease-related information, gut microbiota composition, cancer-related symptoms, dietary intake, and levels of pro-inflammatory cytokines, LPS were collected…
- Trial name
- NCT07515430
- Testing
- Questionnaires set, fecal sample collecting
- Where
- 2 sites in China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-sen University
Obesity, Childhood
Nutritional Intake and Gut Microbiome
Pediatric obesity has been increasing in prevalence, but concerns have been raised around the world because no treatment has been found. Recently, however, research on gut microbiome has begun to become a new alternative.
- Trial name
- NCT03388411
- Testing
- Gut microbiome profiling
- Where
- South Korea
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Cognitive Performance, Inflammation
Peanut Consumption on Cognitive, Weight, and Inflammation
A multi-school, two-arm parallel cluster-randomized controlled trial will be conducted in 200 healthy young adolescents from Barcelona (Spain) to evaluate the effect of peanut consumption on cognitive performance, weight…
- Conditions
- Cognitive Performance, Inflammation, Weight Change, Body, Adolescents
- Trial name
- PEANUTY (NCT06127511)
- Testing
- Food (peanut)
- Where
- Spain
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Infant Colic, Gut Microbiota
Effect of a Dietary Supplement vs Low-dosage Product on Infant Gastrointestinal Discomfort and Colics
The goal of this clinical trial is to verify whether a food supplement is effective in treating infantile colic of infants aged between 21 days and 9 months and the colonization ability of the gut microbiota by measuring faecal…
- Trial name
- DISIC (NCT07017244)
- Testing
- Verum, Active comparator
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Gastric Bypass Surgery
The Effects of Probiotic Supplementation on the Results of Gastric Bypass Surgery
In this study, patients undergoing the bariatric surgery will be assigned to take either probiotic capsules or placebos from 1 month before surgery to 3 months after the surgery.
- Trial name
- NCT02708589
- Testing
- probiotic
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- National Nutrition and Food Technology Institute
Type 1 Diabetes
Intervention on New Onset-T1D Children
A pilot proof of concept clinical trial will be performed to demonstrate the restoration of gut barrier integrity by administration of beneficial anti-inflammatory gut microbial strains (Lactobacilli-enriched Vivomixx® probiotic)…
- Trial name
- NCT05767450
- Testing
- Probiotic Vivomixx®
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Crohn Disease
Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease
The purpose of this study is to determine the effect of a novel gut microbiota-targeted therapeutic regimen (bowel lavage and antibiotics with or without an antifungal) in the management of active Crohn's Disease (CD) or…
- Trial name
- Holiday (NCT03476317)
- Testing
- Vancomycin, Neomycin, Ciprofloxacin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
SARS-CoV2 Infection, COVID-19, Gut Microbiota, Mucosal Response, Children
COVID-19 and Intestinal Microbiota in Children
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. It appears to cause only mild to moderate upper respiratory symptoms in children, in addition to gastrointestinal symptoms resulting from its penetration into intestinal…
- Trial name
- NCT06503887
- Testing
- Stool sample collection
- Where
- Lebanon
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Type 1 Diabetes
Prebiotics in Patients With Type 1 Diabetes
Evidence suggests that prebiotic fibre can correct dysbiosis, reduce intestinal permeability and improve glycemic control. The investigators hypothesize that microbial changes induced by prebiotics contribute to gut and endocrine…
- Trial name
- NCT04963777
- Testing
- Prebiotic
- Where
- 3 sites in Canada
- Volunteers
- 144 people
- Sponsor
- University of Calgary
Pediatric Obesity
MEDKIDS: Nutritional Intervention With Improved Bread and Bakery Products in Children With Overweight and Obesity
The goal of this randomized crossover clinical trial is to evaluate the effect of an intervention with nutritionally improved bread and bakery products on body composition and metabolic health in children aged 6 to 12 years with…
- Trial name
- MEDKIDS (NCT07786675)
- Testing
- Nutritionally improved bread and bakery products, Conventional bread and bakery products
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Ulcerative Colitis (UC)
Impact of the Novel UC-TREAT Diet on the Gut Microbiome and Its Acceptability in Healthy Adults and Adults With Quiescent Ulcerative Colitis
This will be an open-label dietary intervention study recruiting both healthy adults (≥16y) and adults with quiescent Ulcerative Colitis (UC).
- Trial name
- UC-TREAT (NCT06998277)
- Testing
- Dietary therapy
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Gastrointestinal Diseases
DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect
To assess the effects of Bacillus clausii (Enterogermina®) on fecal microbial flora (using Polymerase Chain Reaction - Denaturing Gradient Gel Electrophoresis - PCR-DGGE - Method) in antibiotic-treated children with complicated…
- Trial name
- NCT00424905
- Testing
- Bacillus clausii
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Sanofi
Eczema, Allergy
Probiotics in Prevention of Allergies, Obesity and Caries
During the period of 2000-2003, 179 healthy, term infants with no previous signs of allergic disease were recruited and randomized to daily intake of cereals with or without the addition of Lactobacillus paracasei subspecies…
- Conditions
- Eczema, Allergy, Asthma, Obesity
- Trial name
- ELEFANT (NCT00894816)
- Testing
- Lactobacillus F19
- Where
- Sweden
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Umeå University
Dysbiosis, Prophylaxis
Lactobacillus Reuteri DSM 17938 in Gut Microbiota Development in Infant Born by Caesarean Section
The aim of this study is to assess influence of probiotic Lactobacillus reuteri DSM 17938 on formation of gut microbiota in infant born by Caesarean section.
- Trial name
- NCT03675048
- Testing
- BioGaia Protectis drops
- Where
- Russia
- Volunteers
- 97 people
- Sponsor
- BioGaia AB
Gestational Diabetes Mellitus in Childbirth, Neurodevelopmental Disorders
Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers
The prospective multicenter study GD-Brain provides a better knowledge on the basis of neurological impairment in children born to mothers with gestational diabetes (GDM).
- Trial name
- GD-BRAIN (NCT03032991)
- Where
- Spain
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia