Clinical trials: Intestinal Flora
Cerebral Palsy, Chronic Constipation
Synbiotic, Prebiotics and Probiotics in Children With Cerebral Palsy and Constipation
Randomized double blind controlled clinical trial. Participants will be enrolled at the New Civil Hospital of Guadalajara "Dr. Juan I. Menchaca" during the period from May 2017 to July 2018, from six to 59 months of either sex.
- Trial name
- NCT03117322
- Testing
- agave inulin, Lactobacillus reuteri DSM 17938, maltodextrin
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Andrea Garcia Contreras
Premature Birth, Neurodevelopmental Disorders
Probiotics Supplementation for Neurodevelopment in Preterm Infants
The purpose of this randomized controlled trial is to evaluate the effect of daily supplementation with a probiotic mixture on the neurodevelopmental outcomes of preterm infants with a history of neonatal antibiotic exposure.
- Conditions
- Premature Birth, Neurodevelopmental Disorders, Dysbiosis
- Trial name
- NCT07617181
- Testing
- Probiotic Mixture (Bifidobacterium animalis subsp. lactis Bb-12 and Lacticaseibacillus rhamnosus LGG)
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Fudan University
Hematopoietic Stem Cell Transplantation (HSCT), Acute GVH Disease
Gut Decontamination In Pediatric Allogeneic Hematopoietic
This research study is for participants who are undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and are at risk for developing acute graft-versus-host disease (GVHD).
- Trial name
- NCT02641236
- Testing
- Vancomycin-polymyxin B
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Probiotic, Ocular Surface Disease
Efficacy and Safety of Oral Probiotics on Ocular Symptoms and Gut Microbiome of Children with Vernal Keratoconjunctivitis
The primary goal of this study is to determine the effects of oral probiotics on the severity of ocular symptoms and the alterations of the gut microbiome of children (4-18 years old) with vernal keratoconjunctivitis.
- Conditions
- Probiotic, Ocular Surface Disease, Ocular Diseases, Ocular Dryness
- Trial name
- NCT06793514
- Testing
- Probiotic
- Volunteers
- 32 people
- Sponsor
- Mohsen Pourazizi
Neurocognitive Impairment
Effects of Docosahexanoic Acid on Neurocognitive Impairment in HIV-infected Patients
Neurocognitive impairment (NCI) is one of the serious complications of elderly HIV-infected patients. The destruction of intestinal mucosal barrier and imbalance of bacterial flora caused by aging and HIV infection may be an…
- Trial name
- NCT04242004
- Testing
- Docosahexaenoic acid (DHA) capsules, Soy oil capsules
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Fudan University
Healthy
Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults
Consumption of (poly)phenols is recognized to have beneficial effects on health. However, heterogeneous results are obtained in clinical trials due to high inter-individual variability.
- Trial name
- NCT05931237
- Testing
- Cranberry extract capsules
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Laval University
Gut Microbiota, Constipation
Fecal Microbiota Transplantation for Constipation
Difficult defecation is a common symptom involving with patients'life quality. The stool pattern of these patients might be related to the contribution of gut microbiota.
- Trial name
- NCT03308461
- Testing
- Fecal Microbiota suspension
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Colorectal Cancer
Impact of Probiotics in Modulation of Intestinal Microbiota
The investigators would study about impact of the administration of probiotics in the intestinal mucosa of patients undergoing resection colic, by evaluating cytokine profile by quantitative real time PCR.
- Trial name
- NCT01895530
- Testing
- Saccharomyces boulardii
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Maria Isabel Toulson Davisson Correia
Atopic Dermatitis
Evaluate the Efficacy of Using Modified Qing-Ying Decoction in Atopic Dermatitis Children
The study aims to evaluate the clinical efficacy and safety of the modified Qing-Ying Decoction (mQYD) for the treatment of subacute and chronic atopic dermatitis (AD) in children when compared to the placebo control through…
- Trial name
- NCT04419584
- Testing
- Modified Qing-Ying Decoction
- Where
- Hong Kong
- Volunteers
- 64 people
- Sponsor
- Chinese University of Hong Kong
Transplantation Infection, Kidney Transplant; Complications
Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients
This is a pilot study designed to investigate the alterations in the gut microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic hematopoietic stem cells and mesenchymal stem cells…
- Conditions
- Transplantation Infection, Kidney Transplant; Complications, Stem Cell Transplant Complications, Liver Transplant; Complications
- Trial name
- NCT04281797
- Testing
- Intestinal microbiome new generation sequencing
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
Epidermolysis Bullosa, Epidermolysis Bullosa Simplex
A Pilot Study to Explore the Role of Gut Flora in Epidermolysis Bullosa
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Epidermolysis Bullosa, Epidermolysis Bullosa Simplex, Epidermolysis Bullosa Dystrophica
- Trial name
- NCT04213703
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Cholesterol, Elevated, Elevated Cholesterol
A Pilot Study to Explore the Role of Gut Flora in Elevated Cholesterol
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Elevated Cholesterol.
- Trial name
- NCT04148339
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Iron Deficiency, Anemia
The Effects of Iron and Omega-3 Fatty Acid Supplementation on Cognition and Immune Function in Iron Deficient Children
The aim of this study is to determine if providing iron and a mixture of DHA and EPA, alone and in combination, to children with iron deficiency and poor n-3 fatty acid intake will improve their cognitive performance, activity…
- Trial name
- FeFA (NCT01092377)
- Testing
- DHA and EPA Fish Oil capsule, Iron tablet
- Where
- South Africa
- Volunteers
- 320 people
- Sponsor
- North-West University, South Africa
Cyanotic Congenital Heart Disease
Probiotics in Infants With Cyanotic Congenital Heart Disease
Infants with congenital heart disease have more frequent infections and exposures to antibiotics than healthy infants. It is unknown how congenital heart disease affects the development of bacterial colonization of the…
- Trial name
- NCT01018472
- Testing
- Bifidobacterium infantis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Davis
Micronutrient Deficiencies
Effect of Sprinkles With and w/o Fe on Zn Absorption in Kenyan Toddlers
The investigators propose to study the effects of increased iron intake by home fortification of complementary foods on the gastrointestinal microbial development, inflammatory responses, and zinc (Zn) absorption.
- Trial name
- NCT02101723
- Testing
- MNP + Zn/Fe, MNP + Zn
- Where
- 2 sites in United States, Kenya
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Eczema, Asthma
Influence of Probiotics on Atopy, Immunological Responses and Gut Microflora - Follow-up to 5 Years
The investigators had conducted a double-blind, randomized placebo-controlled clinical trial studying the effects of 6 months probiotics supplementation from birth on allergic disease and sensitization up to 2 years of age.
- Conditions
- Eczema, Asthma, Allergic Rhinitis
- Trial name
- NCT00365469
- Testing
- Probiotic
- Where
- Singapore
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Juvenile Idiopathic Arthritis
(1,3)-Béta-D-Glucan Levels at Diagnosis of Juvenile Idiopathic Arthritis and Its Correlation With Activity's Disease : a Cohort Sudy
Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease of childhood. Most children still experience prolonged periods of active disease, however, there is still lack of effective and specific markers…
- Trial name
- BDG -JIA (NCT03984669)
- Testing
- The Juvenile Disease Activity Score (JADAS), (1-3)-ß-D-Glucan (BDG) assay (Fungitell)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chalazion
Probiotics for Chalaziosis Treatment in Children
There is growing evidence encouraging the use of probiotics in many conditions in children. The aim of the investigator's study is to define the possible beneficial impact of probiotics on paediatric patients affected by…
- Trial name
- NCT04322500
- Testing
- probiotics, conservative treatment
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- University of Molise
Biliary Atresia, Intrahepatic Cholestases
Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)
A prospective observational study in infants with biliary atresia and controls to determine whether the composition of the intestinal microbiome is specific for biliary atresia will be conducted.
- Conditions
- Biliary Atresia, Intrahepatic Cholestases, Normal Controls
- Trial name
- BA (NCT03890536)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Gut Microbiota
Effect of an Infant Formula With Synbiotics in Infants Born Via Caesarean Section
A multi-centre, randomized, parallel-group, double-blind, controlled, exploratory clinical trial is conducted to assess the positive effect of feeding a formula containing synbiotics (pre- and probiotics) on the composition of…
- Trial name
- GOLF-CS (NCT04991792)
- Testing
- Intervention Group 1: Infant Formula with synbiotics, Intervention Group 2: Infant Formula with prebiotics, Control Group 1 and 2: Infant Formula without synbiotics
- Where
- Bulgaria
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- HiPP GmbH & Co. Vertrieb KG