Clinical trials: Intestinal Helminthiasis
Intestinal Helminthiasis, Ascariasis
Impact of Repeated Anthelmintic Treatment on the Risk of Malaria in Kenyan School Children
Many school children in Kenya are infected with plasmodia and helminth species and are at risk of coinfection. It has been suggested that the immune response evoked by helminth infections may modify immune responses to plasmodia…
- Conditions
- Intestinal Helminthiasis, Ascariasis, Hookworm, Malaria
- Trial name
- NCT01658774
- Testing
- Albendazole, Vitamin C
- Where
- Kenya
- Volunteers
- 2,377 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Toxocara Infection
The Effectiveness of Albendazole Treatment Among Infected Toxocara Children
This study consists 2 phases. The first phase will conduct a cross-sectional study to determine the infection rate of Toxocariasis larvae, describe the clinical and paraclinical characteristics, identify risk factors related to…
- Trial name
- NCT05208333
- Testing
- Albenza 200Mg Tablet
- Volunteers
- 960 people
- Sponsor
- Pham Ngoc Thach University of Medicine
Cysticercosis
EFECAB: Improving Pig Management to Prevent Epilepsy in Burkina Faso
This is a pre-post randomized community-based controlled trial aimed at estimating the effectiveness of an educational package developed using PRECEDE PROCEED to reduce the cumulative incidence of Taenia solium cysticercosis in…
- Trial name
- EFECAB (NCT03095339)
- Testing
- Educational package
- Where
- Burkina Faso
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Lymphatic Filariasis, Onchocerciasis
Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
Approximately 5,200 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis and onchocerciasis endemic areas.
- Conditions
- Lymphatic Filariasis, Onchocerciasis, Soil Transmitted Helminth (STH) Infections
- Trial name
- DOLF-LIBERIA (NCT01905436)
- Testing
- Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
- Where
- Liberia
- Volunteers
- 21,862 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Strongyloidiasis, Strongyloides Stercoralis Infection
Evaluation of Strongyloidiasis in Ecuador: a fieLd Laboratory Accuracy Study
the World Health Organization (WHO) has recently committed to promote the control of strongyloidiasis within 2030 targets for STH control programmes.
- Trial name
- ESTRELLA (NCT04999774)
- Testing
- Different diagnostic tests
- Where
- Ecuador
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Trichuriasis, Ascariasis
Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC
This study is a double-blind randomized controlled superiority trial aiming at providing evidence on the efficacy and safety of co-administered moxidectin and albendazole compared to albendazole monotherapy in school-aged…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections
- Trial name
- Moxiped (NCT06188715)
- Testing
- Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet
- Where
- Tanzania
- Volunteers
- 224 people
- Sponsor
- Jennifer Keiser
Schistosomiasis Mansoni, Portal Hypertension
Treatment Schistosomal Portal Hypertension: Efficacy of Endoscopy or Surgery
Upper gastrointestinal bleeding (UGIB) is a major cause of morbidity and mortality in patients with portal hypertension secondary to schistosomiasis mansoni.
- Conditions
- Schistosomiasis Mansoni, Portal Hypertension, Upper Gastrointestinal Bleeding
- Trial name
- NCT01931826
- Testing
- Endoscopic treatment, Total EGDS+ endoscopy
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Universidade Estadual de Ciências da Saúde de Alagoas
Intestinal Helminthiasis, Diarrhea
The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children
Cheap and effective drugs called 'anthelmintics' are routinely administered to children in developing countries to eliminate infections by parasitic helminths.
- Trial name
- NCT02597556
- Testing
- Albendazole
- Where
- Vietnam
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Cysticercosis, Helminthiasis
Taenia Solium Control Case Study in Zambia
Summary Diseases due to T. solium and soil transmitted helminths (STHs) are of cosmopolitan distribution and strongly linked with poor sanitation and poverty.
- Trial name
- SANTOSOIL (NCT01368354)
- Testing
- CLTS
- Where
- Zambia
- Volunteers
- 1,197 people
- Sponsor
- University of Zambia
Helminth Infection
Intestinal Microbiome Post-Azythromycin/Albendazole Treatment
Molecular testing of the gut microbiome and enteric pathogens is rapidly moving beyond targeted PCR testing to next generation sequencing techniques.
- Trial name
- NCT03032042
- Testing
- Azithromycin, Albendazole, Delayed treatment
- Where
- Ethiopia
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Taenia Solium Taeniasis
Targeted Screening for Taenia Solium Tapeworms
The purpose of this study is to determine whether screening and treatment of tapeworm carriers can decrease community transmission of Taenia solium parasitic infection.
- Trial name
- NCT01296958
- Testing
- Niclosamide, Community education campaign
- Where
- Peru
- Volunteers
- 1,811 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Urinary Schistosomiases
Circulating Cathodic Antigen Test Compared to Microscopy for Diagnosis of Urinary Schistosomiasis in Sohag
Schistosomiasis is a chronic infection endemic in 74 tropical and sub-tropical countries. Sub-Saharan Africa carries the highest burden (90%) of schistosomiasis which caused by both Schistosoma mansoni and Schistosoma…
- Trial name
- NCT05276414
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Onchocerciasis
Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection
This is a Phase 3 study comparing the efficacy, safety and tolerability of moxidectin and ivermectin in subjects infected with Onchocerca volvulus, which is the parasite that causes river blindness.
- Trial name
- NCT00790998
- Testing
- Moxidectin, Ivermectin
- Where
- 4 sites in Democratic Republic of the Congo, Ghana and 1 more
- Volunteers
- 1,497 people
- Sponsor
- Medicines Development for Global Health
Trichuriasis
Efficacy and Safety of IVM/ALB Co-administration
This study is a double-blind randomized clinical trial conducted with two settings in Africa and one in Asia, namely Côte d'Ivoire, Pemba (Zanzibar, Tanzania) and Lao PDR.
- Trial name
- NCT03527732
- Testing
- Albendazole, Albendazole and Ivermectin
- Where
- 3 sites in Côte d’Ivoire, Laos and 1 more
- Volunteers
- 1,673 people
- Sponsor
- Jennifer Keiser
Schistosomiasis Hematobium, Diagnostic
Schistosomiasis Diagnosis Using a CAA Antigen Test
Schistosomiasis is one of most important human parasitic diseases worldwide. Pregnant women and their infants are two vulnerable population groups, particularly in sub-Saharan Africa, where - amongst other infectious agents …
- Conditions
- Schistosomiasis Hematobium, Diagnostic, Drug Reaction, Pregnancy
- Trial name
- FreebiLyGAB (NCT03779347)
- Testing
- Praziquantel, UCP-LF CAA, composite diagnostic
- Where
- 2 sites in Gabon
- Volunteers
- 100 people
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Malaria, Schistosomiasis
Correlating Protection Against Malaria With Serum Profiles Against Plasmodium Falciparum Antigen Repertoires
A longitudinal study on immune responses in relation to protection against clinical malaria episodes will be conducted in Apac District, Uganda.
- Conditions
- Malaria, Schistosomiasis, Hiv Infection
- Trial name
- NCT01214876
- Where
- Uganda
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Schistosomiasis, Malaria
The Effect of Praziquantel Treatment on Schistosoma Mansoni Morbidity and re-Infection Along Lake Victoria, Uganda
The overall objective of the project is to contribute to an increased knowledge about the effect of praziquantel on schistosomiasis related morbidity and re-infection level among communities living along Lake Victoria in Mayuge…
- Trial name
- NCT00215267
- Testing
- praziquantel
- Where
- Uganda
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Malaria, Filariasis
Medical Implications of Coinfection With Malaria and Filariasis Parasites
This study will examine the clinical, immunological and epidemiological effects of concurrent infections with P. falciparum and W. bancrofti or M.
- Trial name
- NCT00471666
- Where
- Mali
- Volunteers
- 1,039 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Onchocercal Subcutaneous Nodule, Epilepsy
Onchocerciasis-Associated Epilepsy, an Explorative Case-control Study
This is an exploratory case control study with the aim to compare the Onchocerca volvulus virome between persons with onchocerciasis-associated epilepsy (OAE) and persons with onchocerciasis but without epilepsy.
- Conditions
- Onchocercal Subcutaneous Nodule, Epilepsy, Virus
- Trial name
- NCT05868551
- Testing
- nodulectomy
- Where
- South Sudan
- Volunteers
- 40 people
- Sponsor
- Universiteit Antwerpen
Schistosomiasis
Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis
Background: Schistosomiasis is a chronic infection. It is caused by parasitic worms called Schistosoma haematobium (Sh) that are spread by snails that live in rivers. It can lead to liver problems or bladder cancer.
- Trial name
- NCT02734186
- Testing
- Praziquantel
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)