Clinical trials: Intestinal Helminthiasis
Fascioliasis
Study of Safety, Tolerability and Clinical Outcomes of Egaten in Fascioliasis Patients (6 Years of Age or Older).
The study evaluated safety and tolerability along with clinical outcomes of Egaten administered as per the FDA approved dosing regimen of 2 doses of 10 mg/kg (given approximately 12 hours apart) in Fascioliasis participants (≥ 6…
- Trial name
- NCT04230148
- Testing
- Egaten (Triclabendazole) 250 mg tablets
- Where
- 10 sites in Colombia, Egypt and 3 more
- Volunteers
- 301 people
- Sponsor
- Novartis Pharmaceuticals
Parasitic Diseases, Bacterial Diseases
Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination
The purpose of this study is to determine whether the triple co administration of albendazole, ivermectin and azithromycine is as safe as the current treatment scheme that consists to treat with albendazole plus ivermectin…
- Trial name
- AZIVAL (NCT01586169)
- Testing
- triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
- Where
- Mali
- Volunteers
- 3,000 people
- Sponsor
- Centre d'Appui à la lutte contre la Maladie
Mansonella Perstans Infection, Mp Microfilaremia
Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis
This study will examine: 1) the safety and effectiveness of the drug doxycycline in reducing the number of Mansonella perstans (Mp) worms in the blood of infected patients, and 2) the effects of doxycycline followed by…
- Trial name
- NCT00340691
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fascioliasis
Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients .
WHO considers foodborne trematodes as neglected tropical diseases. Fascioliasis is the most widely distributed trematode reported from over 81 countries around the world it imposes its highest burden in developing countries
- Trial name
- NCT03869788
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
W. Bancrofti Filariasis
Research for Elim of Filariasis
Wuchereria bancrofti, is a mosquito-transmitted parasite that causes deforming lymphatic filariasis in the tropics. Improved treatment methods have led to new thinking that it should be possible to interrupt transmission and…
- Trial name
- NCT00145223
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Trichuriasis, Ascariasis
Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration
The aim of this randomized controlled trial is to provide evidence on the efficacy and safety of co-administered moxidectin and albendazole compared to co-administered ivermectin and albendazole, and to assess the efficacy of the…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections, Helminthes; Infestation, Intestinal
- Trial name
- NCT04700423
- Testing
- moxidectin (8 mg) / albendazole (400 mg), ivermectin (200 µg/kg) / albendazole (400 mg), ALBENDAZOLE 400 Mg ORAL TABLET [ZENTEL]
- Where
- Tanzania
- Volunteers
- 536 people
- Sponsor
- Jennifer Keiser
Lymphatic Filariasis
Effect of Albendazole Dose on Clearance of Filarial Worms
This study, conducted in Mali, West Africa, will determine whether a new treatment regimen for lymphatic filariasis can eliminate the disease more quickly than the standard regimen.
- Trial name
- NCT00339417
- Testing
- Albendazole, Ivermectin
- Where
- Mali
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Tuberculosis
Digital Health Promotion in Iringa, Tanzania
Increased health education has the potential to facilitate better use of health care services and to promote early treatment, thus it can strengthen the health care system, and ultimately reduce morbidity and mortality.
- Conditions
- HIV Infections, Tuberculosis, Cysticercosis, Tapeworm Pork
- Trial name
- NCT03808597
- Testing
- Digital health promotion intervention
- Where
- 6 sites in Tanzania
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Hookworm Infections
Mebendazole Study Against Hookworm Infections in Children and Adolescents in Ghana
The Ghana study will hypothesize that both the multiple dose and single dose of mebendazole will achieve effective cure rates against hookworm among children and adolescents.
- Trial name
- NCT03261596
- Testing
- Mebendazole
- Where
- Ghana
- Sponsor
- PATH
Lymphatic Filariasis
Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali
Lymphatic filariasis is a public health problem in Mali. The existing data are not up to date and most of them are more than 15 years old.
- Trial name
- NCT02784743
- Testing
- ''albendazole'' and ''ivermectin''
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- Centre d'Appui à la lutte contre la Maladie
Neurocysticercosis, Taeniosis
Investigation of Environmental Factors Associated With Transmission of T. Solium in Endemic Villages of Zambia
This study aims to determine the prevalence of taeniosis and (neuro)cysticercosis in two districts in the southern (Gwembe) and eastern province (Chipata) of Zambia.
- Trial name
- TEPIM (NCT03874689)
- Where
- Zambia
- Volunteers
- 2,921 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Filariasis
Exhaled NO Testing in Filariasis
This study is looking at the difference in exhaled nitric oxide levels in patients with and without laboratory evidence of filariasis.
- Trial name
- NCT01628497
- Where
- Guyana
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Schistosomiasis
Treatment of Female Genital Schistosomiasis (FGS) With Praziquantel: A Proof-of-Concept Study
Female genital schistosomiasis (FGS) is a frequent manifestation of the infection with Schistosoma haematobium or mansoni. FGS is probably the most neglected gynaecological condition in the tropics.
- Trial name
- NCT04115072
- Testing
- Praziquantel 600Mg Oral Tablet x 5, Praziquantel 600Mg Oral Tablet x 1
- Where
- Madagascar
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Regionshospital Nordjylland
Soil-transmitted Helminth Infections
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP1 (NCT03465488)
- Testing
- Albendazole Pill 400mg (GSK)
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Schistosomiasis
Monitoring Schistosome Hybrids Under Under Praziquantel Pressure
The overall objective of this project is to examine and quantify the potential existence and impact on Praziquantel (PZQ) efficacy, of naturally occurring S. haematobium and S. bovis hybrid populations in northern Senegal.
- Trial name
- Sen_hybrids (NCT04635553)
- Testing
- Praziquantel 600 milligram
- Where
- Senegal
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Schistosomiasis, Liver Fibrosis
Antioxidant Supplements in the Reversal of Schistosomal Peri-portal Fibrosis
Liver fibrosis is the most serious complication of schistosomiasis mansoni. However only limited proportion of subjects with infection develop this pathology and there is limited knowledge on risk factors for the differential…
- Conditions
- Schistosomiasis, Liver Fibrosis, Periportal Fibrosis, Oxidative Stress
- Trial name
- NCT01260012
- Testing
- Praziquantel+antioxidant suppl, Praziquantel+antioxidant
- Where
- Ethiopia
- Volunteers
- 414 people
- Sponsor
- Addis Ababa University
Helminthiasis, Tinea Capitis
Design and Clinical Evaluation of a School Meal With Deworming Properties
Intestinal parasites (IP) are among the world's neglected tropical diseases. Morbidity due to IPs is greatest in school-age children who typically have the highest burden of infection.
- Conditions
- Helminthiasis, Tinea Capitis, Anemia
- Trial name
- NCT02725255
- Testing
- Ujiplus, Albendazole, uji
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Anaemia, Malaria
Schistosome and Intestinal Worm Infections and Malaria Morbidity Among School and Pre-school Children in, Tanzania
The proposed study has as the main objective to investigate the effect of schistosome and STH infections and the effect of an anthelminthic intervention on P.
- Conditions
- Anaemia, Malaria, Hepatosplenomegaly
- Trial name
- NCT00347113
- Testing
- Albendazole and praziquantel
- Where
- Tanzania
- Volunteers
- 620 people
- Sponsor
- DBL -Institute for Health Research and Development
Lymphedema, Lymphatic Filariasis
A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-Mali (NCT02927496)
- Testing
- Doxycycline
- Where
- Mali
- Volunteers
- 220 people
- Sponsor
- The Task Force for Global Health
Taenia Solium Infection
Taenia Solium Elimination Versus Control: What is the Best Way Forward for Sub-Saharan Africa?
Taenia solium taeniosis/cysticercosis is a neglected zoonotic parasitic disease complex with significant economic and public health impacts, occurring primarily in developing countries.
- Trial name
- CYSTISTOP (NCT02612896)
- Testing
- Mass drug administration, praziquantel 10mg/kg, Health education
- Where
- Zambia
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium