Clinical trials: Intestinal Ischemia
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Mesenteric Ischemia
Multislice Computed Tomography Angiography in Acute Mesenteric Ischemia
Acute mesenteric ischemia is a life-threatening condition with high mortality. Acute mesenteric ischemia is responsible for fewer than one in 1000 hospital admissions, but its mortality rate ranges between 30% and 90% .
- Trial name
- NCT03484442
- Volunteers
- 30 people
- Sponsor
- Assiut University
Bowel Ischemia, Acute Bowel Ischemia / Infarction
Diagnosing Acute Onset Insufficient Intestinal Blood Flow (Bowel Ischemia) With a Novel CT Technique Called Dual-energy CT (DECT). This Observational Study Seeks to Evaluate Whether DECT Can Improve the Diagnosis of Bowel Ischemia and How the DECT Findings Correlate With Intraoperative Findings
The aim of this study is to evaluate the performance of dual-energy CT (DECT) in the diagnosis of acute bowel ischemia (ABI). ABI is a condition characterised by inadequate blood supply to portions of the intestine.
- Trial name
- NCT04561323
- Testing
- Dual-energy CT
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Intestinal Ischemia
Radiological Findings in Primary Intestinal Ischaemia
To investigate which findings on a non-specific CT scan that predict acute primary intestinal ischaemia.
- Trial name
- NCT04361110
- Testing
- Computerized tomography scan of the abdomen
- Volunteers
- 130 people
- Sponsor
- Aalborg University Hospital
Acute Mesenteric Ischemia, Short Bowel Syndrome
Antithrombotic Management of Acute Mesenteric Ischaemia
Guidelines on the acute and long-term pharmacological treatment of acute mesenteric ischaemia (AMI) recommend the use of thrombolytic, antiplatelet or anticoagulant therapy depending on the aetiology of AMI and the use of…
- Trial name
- NCT05706012
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Mesenteric Ischemia
Investigation of Chronic Intestinal Ischemia
Patients suspected of chronic mesenteric ischemia caused by atherosclerosis or median arcuate ligament syndrome shall be investigated with trans mucosal and transserosal laser Doppler flowmeter and visible light spectroscopy.
- Trial name
- NCT02914912
- Where
- 2 sites in Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Chronic Limb-Threatening Ischemia, Colorectal Carcinoma
Comparison of Outcomes of Patients With Stage IV Chronic Limb-threatening Ischemia and Colorectal Cancer
Colorectal cancer (CRC) and chronic limb-threatening ischemia (CLTI) are relatively frequent and potentially fatal diseases. However, studies that are comparing clinical outcomes between CRC and CLTI patients in more advanced…
- Conditions
- Chronic Limb-Threatening Ischemia, Colorectal Carcinoma, Colorectal Carcinoma Metastatic in the Liver
- Trial name
- NCT05116696
- Testing
- For chronic limb-threatening ischemia (CLTI) patients revascularisation surgery; for colorectal liver metastasis (CRLM) patients metastatic liver surgery
- Where
- Serbia
- Volunteers
- 836 people
- Sponsor
- Clinical Centre of Serbia
Necrotizing Enterocolitis of Newborn, Bowel Ischemic
CEUS Evaluation of Bowel Perfusion in Necrotizing Enterocolitis
There is no bedside imaging technique that can quantify dynamic bowel perfusion with high soft tissue contrast and sensitivity in necrotizing enterocolitis (NEC).
- Trial name
- NCT03549507
- Testing
- Sulfur hexafluoride lipid-type A microspheres
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital of Philadelphia
Rectal Neoplasms, Colitis, Ischemic
Anterior Perineal Plane for Ultra Low Anterior Resection of the Rectum
Anal sphincter preserving operations are now commonplace for both cancer and non-cancerous rectal diseases. However, this has not always been the case and this development has been facilitated by the invention of circular…
- Conditions
- Rectal Neoplasms, Colitis, Ischemic, Colitis, Ulcerative
- Trial name
- APPEAR (NCT00534131)
- Testing
- Standard abdominal approach for rectal excision, APPEAR Procedure, Proctectomy
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Queen Mary University of London
Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been…
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia, Acute Kidney Injury, Non-Occlusive Mesenteric Ischaemia
- Trial name
- aMIKI (NCT06365827)
- Testing
- observational study
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Giessen
Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia
Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases
Hypoxic-ischemic encephalopathy (HIE), bronchopulmonary dysplasia (BPD), short bowel syndrome (SBS) are refractory in clinical treatment.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia, Short Bowel Syndrome
- Trial name
- NCT06427642
- Testing
- Mononuclear cells, Mild hypothermia therapy, Breathing support technique
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shandong Qilu Stem Cells Engineering Co., Ltd.
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Necrotizing Enterocolitis
RIC-NEC Randomized Controlled Trial
Necrotizing enterocolitis (NEC) is a serious intestinal disease of preterm and term neonates which remains a major cause of intestinal failure, and an unsolved clinical challenge in pediatrics.
- Trial name
- RIC-NEC (NCT05279664)
- Testing
- Remote ischemic conditioning (RIC) + Standard of Care for NEC, Standard of Care for NEC
- Where
- 4 sites in United States, Canada
- Volunteers
- 78 people
- Sponsor
- The Hospital for Sick Children
Necrotizing Enterocolitis, Intestinal Ischemia
Phase I Clinical Study of Chondroitin Sulfate for Treatment of NEC
The goal of this phase 1 double blind, randomized controlled trial is to determine the safety of chondroitin sulfate supplementation in the neonates with necrotizing enterocolitis.
- Trial name
- NCT06547424
- Testing
- Chondroitin sulfate
- Where
- United States
- Sponsor
- Indiana University
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
Ulcerative Colitis, Myocardial Infarction
Estimation of Cardiovascular Risk in Patients With Crohn's Disease and Ulcerative Colitis (PROVACI)
Inflammatory bowel diseases (IBD) are progressively increasing their prevalence worldwide. Up to half of patients may also have extraintestinal manifestation and cardiovascular diseases (CVDs) is one of the most relevant, being…
- Conditions
- Ulcerative Colitis, Myocardial Infarction, Stroke, Ischemic Heart Disease
- Trial name
- PROVACI (NCT07095634)
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Mesenteric Ischemia
Predictive Factors of Intestinal Infraction in Acute Mesenteric Ischemia
The study aims to identify several factors that can accurately predict the incident of intestinal infraction in patients with mesenteric vascular occlusion or ischemia.
- Trial name
- NCT02645240
- Testing
- Heparin injection
- Where
- Egypt
- Volunteers
- 97 people
- Sponsor
- Mansoura University
NEC, Atresia
Safety and Feasibility of Indocyanine Green Fluorescence for Intraoperative Assessment of Intestinal Perfusion in Young Infants and Neonates
The goal of this clinical trial is to test the use of the SPY-PHI device for the purpose of ICG-mediated intestinal perfusion visualization during gastrointestinal surgery in neonates and young infants (<3 months old) undergoing…
- Conditions
- NEC, Atresia, Malrotation, Intestinal Perforation
- Trial name
- IMAGINE (NCT05734118)
- Testing
- Perfusion assessment by means of the SPY-PHI camera
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Ischemic Bowel Disease
Clinical Application and Mechanism of Cord Blood Mononuclear Cells in the Treatment of Ischemic Bowel Disease
Ischemic bowel disease, also known as ischemic bowel disease (IBD), is a type of disease that causes the blood supply to a certain intestinal segment to be reduced or stopped by various reasons such as hypovolemia, shock or…
- Trial name
- NCT05560672
- Testing
- Human Umbilical Cord blood mononuclear cells
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qianfoshan Hospital
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center