Clinical trials: Intestinal Microbiome
Necrotizing Enterocolitis, Bronchopulmonary Dysplasia
A Cohort Study of the Intestinal Microbiota of Premature Infants
Premature infants are at risk for a variety of diseases, the investigators would like to learn more about why some premature babies are at higher risk and some are protected from these diseases.
- Conditions
- Necrotizing Enterocolitis, Bronchopulmonary Dysplasia, Growth Failure
- Trial name
- NCT03717584
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Davis
Influenza
The Interaction Between Mucosal Microbiota Colonization and the Immune Response to an Intranasal Influenza Live Attenuated Vaccine
This is a single-center, randomized, open-label trial designed to explore the interaction between mucosal microbiota colonization in the nasal cavity and gut and the immune response to an intranasal live attenuated influenza…
- Trial name
- NCT06609811
- Testing
- Intranasal Influenza Live Attenuated Vaccine
- Where
- China
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Health
Effects of Coffee Consumption on Health Among Adults
The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard…
- Trial name
- NCT03817944
- Testing
- Warm Water, Caffeinated Coffee, Decaffeinated Coffee
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Obesity, Childhood
Nutritional Intake and Gut Microbiome
Pediatric obesity has been increasing in prevalence, but concerns have been raised around the world because no treatment has been found. Recently, however, research on gut microbiome has begun to become a new alternative.
- Trial name
- NCT03388411
- Testing
- Gut microbiome profiling
- Where
- South Korea
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Upper Respiratory Tract Infection
Effect of eHealth on AB Use of Children With Acute, Uncomplicated URTIs
The goal of this clinical trial is to test the effectiveness of two self-care eHealth applications in parents of children with uncomplicated upper respiratory tract infections (URTIs).
- Trial name
- NCT06140446
- Testing
- FeverApp, DMT App
- Where
- Netherlands
- Volunteers
- 411 people
- Sponsor
- Max Nieuwdorp
Inflamatory Bowel Disease
Fecal Microbiome Signature of Multi-Strain Probiotics Supplementation in Children and Adolescents With Inflammatory Bowel Disease
In this study the intestinal microbiome and metabolic profiles of patients with inflammatory bowel disease will be determined upon probiotic intervention.
- Trial name
- MicroSig (NCT07533890)
- Testing
- Probiotic Formula, Observation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Childhood Obesity
Effect of POSTbiotics Supplementation on Microbiome in OBese Children: the POST-OB Study
This study evaluates the possible effect of postbiotics supplementation, combined with interventions aimed at improving diet and lifestyle, on gut microbiota composition and metabolite production.
- Trial name
- POST-OB (NCT04151823)
- Testing
- Vitamin D3, Immunofos, Promotion of physical activity
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Milan
Congenital Heart Disease, Intestinal Disease
Effect of Probiotics on Patients With Congenital Heart Disease Following Cardiopulmonary Bypass
A randomized, controlled study including infants with non-cyanosis congenital heart disease (CHD) in need of surgical correction involving cardiopulmonary bypass (CPB) was established.
- Conditions
- Congenital Heart Disease, Intestinal Disease, Dysbiosis
- Trial name
- NCT06295575
- Testing
- probiotics containing Bifidobacterium infantis and Lactobacillus
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing Children's Hospital
Acute Lymphocytic Leukemia
Effect of Oral Supplementation With a Fibre Enriched Paediatric Sip Feed For Children With Acute Lymphocytic Leukemia
This is a randomised, controlled, open-label intervention study. It is hypothesized that supplementation with a fibre enriched sip feed will improve the nutritional status, gut microbiota and quality of life (QOL) of children…
- Trial name
- NCT01600781
- Testing
- NutriniDrink/Fortini MF unflavoured (1.5kcal/ml)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Graft Vs Host Disease
Alterations in Intestinal Microbiota, Metabolites, and Immune Cells in Allo-HSCT
This research project delves into the critical role of gut immunity in the occurrence and progression of acute graft-versus-host disease (aGVHD) post allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- NCT06143501
- Testing
- Blood Sample, Stool Sample, Urine Sample
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Gut Microbiome, Neurocognitive Correlates of Eating Habits
Early Avocado Exposure on Development and the Gut Microbiome in American Hispanic Infants
The goal of this clinical trial is to learn if daily avocado intake can improve growth and brain and gut health in infants. The main questions it aims to answer are: Does daily eating of avocados change which microbes live in the…
- Conditions
- Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infant Growth
- Trial name
- Guac & Grow (NCT06876935)
- Testing
- Daily avocado
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
End Stage Renal Disease (ESRD), Kidney Failure, Chronic
Probiotic and Synbiotic Supplements in Hemodialysis Patients
This single-center randomized controlled trial evaluated the effects of natural probiotic and synbiotic supplementation on clinical and biochemical characteristics in adults with end-stage renal disease receiving maintenance…
- Conditions
- End Stage Renal Disease (ESRD), Kidney Failure, Chronic, Hemodialysis
- Trial name
- NCT07531186
- Testing
- Natural Probiotic Supplement, Natural Synbiotic Supplement (Probiotic + Prebiotic Oat Fiber)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Autism Spectrum Disorder
Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
The aim of this study is to assess the effects of a 6-months probiotic supplementation on behavioral profiles, microbiota and metabolic profiles, inflammatory biomarkers, gastrointestinal disturbances, in children with Autism…
- Trial name
- NCT04293783
- Testing
- L.Reuteri
- Where
- 2 sites in Italy
- Volunteers
- 43 people
- Sponsor
- University of Rome Tor Vergata
Infant Allergy, Infant Gut Health
Study on the Impact of Different Feeding Methods on Allergy Prevention and Digestive Absorption in Infants and Young Children
Based on a real-world research paradigm, this study aims to evaluate the performance of infants fed via different methods-specifically goat milk formula, control formula, and breastfeeding-regarding allergy prevention and protein…
- Conditions
- Infant Allergy, Infant Gut Health, Infant Respiratory Diseases, Infant Feeding Scale
- Trial name
- NCT07886437
- Testing
- Observation, biological sample collection: stool
- Where
- China
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Malnutrition, Diarrhea
Evaluation of Zinc and / or Micronutrient Supplementation on Intestinal Flora, Diarrheal Disease Burden, Intestinal Mucosal Integrity and Growth Among Children of Pakistan
Information on the mechanisms of zinc is still in developing phase. Ecological and biological implications of long term zinc supplementation at population level requires assessment.
- Conditions
- Malnutrition, Diarrhea, Pneumonia, Growth
- Trial name
- NCT00705445
- Testing
- Micronutrient Supplementation without Zinc, Micronutrient Supplementation with Zinc, Nutritional Counselling and Education
- Where
- 2 sites in Pakistan
- Volunteers
- 2,745 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Lupus Erythematosus, Lupus Erythematosus, Systemic
A Pilot Study to Explore the Role of Gut Flora in Lupus
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Trial name
- NCT04213690
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Microbial Colonization
Probiotics and Intestinal Microbiome in Preterm Infants
The gut microbiome plays a significant role in balancing the inflammatory system in the immature gut. A breakdown in this balance with altered colonization of the microbiota in very low birth weight (VLBW) preterm infants is…
- Trial name
- NCT03422562
- Testing
- Florababy
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Belal Alshaikh
Obesity, Childhood
Combining Prebiotic and Diet/Physical Activity Educational Program Effects on Body Composition and Intestinal Microbiota in Children
The purpose of this study was to determine the feasibility, acceptability, and initial efficacy of combining prebiotic (Beneo Synergy 1) and calcium treatment with Project FUN (an online nutrition and physical activity program)…
- Trial name
- NCT05671731
- Testing
- Beneo Synergy 1, Project FUN
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Marquette University
Pitt Hopkins Syndrome
Microbiota Transfer Therapy for Children and Adults With Both Pitt Hopkins Syndrome and Gastrointestinal Disorders
The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating patients with Pitt-Hopkins Syndrome (PTHS) and gastrointestinal problems (constipation, bloating, abdominal pain).
- Trial name
- NCT06321796
- Testing
- MTP-101P, Vancomycin, Magnesium Citrate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gut-Brain-Axis Therapeutics Inc.