Clinical trials: Intestinal Polyps
Colonic Polyps, Adenomatous Polyps
Practice-Based Learning to Predict Polyp Histology at Colonoscopy
Most colorectal cancers arise from polyps. Most polyps removed at colonoscopy are small. New technologies such as narrowband imaging (NBI) offer the possibility of in differentiation between precancerous and unimportant small…
- Trial name
- NCT01638091
- Testing
- Ex vivo module, In vivo practice-base learning phase
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stanford University
Ulcerative Colitis, Crohn Disease
Evaluation of the Diagnostic Value of microRNAs for Inflammatory Bowel Diseases
The purpose of this study is to assess the diagnostic value of microRNAs in IBD colon (ulcerative colitis or Crohn's disease) in adults as compared to healthy controls (and non-IBD colitis)
- Conditions
- Ulcerative Colitis, Crohn Disease, Healthy, Non-IBD Colitis
- Trial name
- MicroMICI (NCT02020382)
- Testing
- qPCR diagnostic KIT of microRNAS
- Where
- 5 sites in France
- Volunteers
- 325 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adenomatous Polyposis Coli
Post-Trial Access for Guselkumab in Participants With Familial Adenomatous Polyposis
The purpose of this post-trial access (PTA) program is to provide guselkumab to participants with Familial Adenomatous Polyposis (FAP) who are experiencing clinical benefit after completing 48 weeks of treatment in Study…
- Trial name
- NCT04948398
- Testing
- Guselkumab
- Sponsor
- Janssen Research & Development, LLC
Peutz-Jeghers Syndrome
Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
The mutation of STK11 has been regcognized to be the major cause of Peutz-Jeghers syndrome (PJS).The aim of this study was to confirm the mutation rate of gene associated with gastrointestinal malignancies,including STK11…
- Trial name
- NCT03806075
- Testing
- Second generation sequencing, 16s rRNA gene sequencing
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yiqi Du
Colorectal Adenoma, Colorectal Polyp
EndoRings Colonoscopy vs Standard Colonoscopy
The study aims to compare the results between a standard colonoscopy to a colonoscopy with an attachment on the distal end of the colonoscope.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colon Cancer
- Trial name
- NCT03418662
- Testing
- EndoRings device
- Where
- United States
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colorectal Cancer, Adenomatous Polyp of Colon
CRC Screening Using mSEPT9 (Methylated Septin 9) in Chinese Population
The purpose of this study is to evaluate the performance of the SEPT9 gene methylation assay in Colorectal cancer (CRC) high-risk population in Chinese hospitals using the opportunistic screening method.
- Conditions
- Colorectal Cancer, Adenomatous Polyp of Colon, Polyps, Other Disease/Injury
- Trial name
- RESEPT (NCT02540850)
- Where
- 4 sites in China
- Volunteers
- 1,031 people, healthy volunteers welcome
- Sponsor
- BioChain (Beijing) Science and Technology, Inc.
Colonic Neoplasms
The Influence of Artificial Intelligence (AI )Assisted Polyp Detection (Discovery System) on Visual Gaze Patterns During Real-time Colonoscopy
In this study, the investigators aim to assess the influence of a computer-aided detection (CADe) system on the visual gaze patterns of endoscopists in order to further understand the effect of AI during real-time colonoscopy.
- Trial name
- REVEAL (NCT05619614)
- Testing
- eye-tracking glasses
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- Radboud University Medical Center
Colonic Polyp
Improving Polyp Detection Rate by Artificial Intelligence in Colonoscopy
The aim of this study is to investigate if the use of artificial intelligence (AI) in colonoscopy improves the polyp detection rate, and if the use of AI has a learning effect.
- Trial name
- NCT05322993
- Testing
- GI Genius, Standard white light colonoscope
- Where
- 3 sites in Norway
- Volunteers
- 5,034 people, healthy volunteers welcome
- Sponsor
- Haraldsplass Deaconess Hospital
Colorectal Cancer, Neoplasm of Uncertain Malignant Potential
Fludeoxyglucose F 18 PET Imaging in Determining Protein and Gene Expression Signatures in Patients With Premalignant Polyps or Colon Cancer
RATIONALE: Diagnostic imaging procedures, such as fludeoxyglucose F 18 PET, may be effective in detecting cancer or recurrence of cancer, or premalignant polyps.
- Trial name
- NCT00550628
- Testing
- DNA methylation analysis, fluorescence in situ hybridization, gene expression analysis
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP)
Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)
RIPAF (Rete Italiana Poliposi Adenomatosa Familiare) is a national, multicenter observational registry designed to establish a coordinated Italian network for the management of Familial Adenomatous Polyposis (FAP) and related…
- Conditions
- Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP), MUTYH-Associated Polyposis (MAP), Non-APC/MUTYH Associated Polyposis (NAMP)
- Trial name
- RIPAF (NCT07461246)
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Colorectal Polyp, Colorectal Neoplasms
Real-time AI-assisted Endocyroscopy for the Diagnosis of Colorectal Lesions
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death worldwide. Colonoscopy is considered the preferred method of screening for colorectal cancer, and early and…
- Trial name
- NCT06791395
- Testing
- Computer-aided diagnosis (CADx) support tool
- Where
- 3 sites in China
- Volunteers
- 570 people
- Sponsor
- The First Hospital of Jilin University
Colon Cancer, Diverticulitis
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
A database has been established to track the outcomes of all cases performed in the University Hospitals Department of Surgery in an effort to improve quality of surgical performance and case management.
- Conditions
- Colon Cancer, Diverticulitis, Colorectal Polyps, Crohn's Disease
- Trial name
- SOCRATES (NCT00622557)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- University Hospitals Cleveland Medical Center
Colonic Polyp, Colon Adenoma
Colonoscopic Adenoma and Advanced Neoplasia Detection Rates According to Age
Current recommendations for colonoscopy screening programs usually involve patients older than 50 years of age. However, little is known about polyp or adenoma detection rates under 50.
- Conditions
- Colonic Polyp, Colon Adenoma, Colonoscopy, Colon Cancer
- Trial name
- NCT03361904
- Testing
- Colonoscopy
- Volunteers
- 6,027 people
- Sponsor
- Société Française d'Endoscopie Digestive
Acute Leukemia, Adenomatous Polyposis
Familial Investigations of Childhood Cancer Predisposition
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll.
- Conditions
- Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma, AML
- Trial name
- SJFAMILY (NCT03050268)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- St. Jude Children's Research Hospital
Colon Polyp
Effect of the Computer Aided Diagnosis with Explainable Artificial Intelligence for Colon Polyp on Optical Diagnosis and Acceptance of Technology
The goal of this clinical trial is to learn if computer-aided diagnosis with deep learning and computer-aided diagnosis with explainable AI work to optical diagnosis performance and acceptance of technology in endoscopists.
- Trial name
- NCT06617468
- Testing
- computer-aided diagnosis with explainable AI, computer-aided diagnosis with deep learning
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Seoul National University Hospital
Familial Adenomatous Polyposis, Colorectal Cancer
Multimedia Intervention in Patients With Familial Adenomatous Polyposis (FAP)
The goal of this research study is to test the first version of a website that will offer information and support for adolescents and young adults with FAP.
- Trial name
- NCT00525655
- Testing
- Web-Based Multimedia Intervention, Questionnaire
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Hereditary Non-polyposis Colon Cancer
Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer
RATIONALE: Gathering medical and family history information from patients and family members may help doctors better understand hereditary colorectal cancer and hereditary polyposis syndrome and identify patients at high risk of…
- Conditions
- Colorectal Cancer, Hereditary Non-polyposis Colon Cancer, Precancerous Condition
- Trial name
- NCT00675636
- Testing
- study of socioeconomic and demographic variables, evaluation of cancer risk factors, study of high risk factors
- Where
- 3 sites in United States
- Volunteers
- 730 people
- Sponsor
- Vanderbilt University Medical Center
Polyp of Colon
Artificial Intelligence (AI) Validation Study for Polyp Detection
Interventional prospective multicenter study: Polyp detection by an automated endoscopic tool as second observer during routine diagnostic colonoscopy
- Trial name
- NCT04378660
- Testing
- Artificial intelligence for polyp detection
- Where
- Belgium
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colorectal Cancer, Colon Polyp
Colorectal Cancer Screening Using Stool DNA-based SDC2 Methylation Test
A study of colorectal cancer screening using stool DNA-based SDC2 methylation test
- Conditions
- Colorectal Cancer, Colon Polyp, Healthy
- Trial name
- NCT04304131
- Testing
- Earlytect Colon Cancer
- Where
- 8 sites in South Korea
- Volunteers
- 1,210 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Familial Adenomatous Polyposis
Review of Post-Study Clinical Endoscopy Reports in Follow Up to MAY2016-07-01
This study reviews post study clinical endoscopy reports in follow up to patients who participated in MAY2016-07-01 with weekly erlotinib for familial adenomatous polyposis.
- Trial name
- NCT04674228
- Testing
- Electronic Health Record Review
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)