Clinical trials: Intestines Cancer
Non-Small Cell Lung Cancer, Medullary Thyroid Cancer
A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
This is an open-label, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity of selpercatinib (also known as LOXO-292) administered orally to participants…
- Conditions
- Non-Small Cell Lung Cancer, Medullary Thyroid Cancer, Colon Cancer, Any Solid Tumor
- Trial name
- LIBRETTO-001 (NCT03157128)
- Testing
- LOXO-292
- Where
- 85 sites in United States, Australia and 14 more
- Volunteers
- 857 people
- Sponsor
- Eli Lilly and Company
Colorectal Cancer
Efficacy of Combination Immunotherapy in Patients With Metastatic Colorectal Cancer
Immunotherapy improved efficacy and survival in selective patients with metastatic colorectal cancer (mCRC), however, limited data revealed the landscape of immunotherapy efficacy.
- Trial name
- NCT05414461
- Testing
- Combinations
- Where
- China
- Volunteers
- 97 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Colorectal Cancer
Study of Tumor Samples From Patients With Stage III Colon Cancer Who Have Undergone Surgery and Chemotherapy
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer who have undergone surgery and chemotherapy may help doctors predict how well patients will respond to treatment.
- Trial name
- NCT00918827
- Where
- Japan
- Volunteers
- 2,128 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Colorectal Cancer
Improving Colorectal Cancer Screening in Racially Diverse Zip Codes Using Navigation and Machine Learning (PCSNaP)
The overarching goal of the "PCSNaP" Research Study is to support the Abramson Cancer Center (ACC) of the University of Pennsylvania in carrying out its mission to increase colorectal cancer (CRC) screening completion among…
- Trial name
- PCSNaP (NCT05383976)
- Testing
- Machine Learning Algorithm with Existing Penn Medicine CRC Patient Navigation Program
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Rectal Cancer
Relationship Between Quality of Life, Treatment Modalities, and Patient Treatment/Outcome Expectations
The goal of this study is to learn how the treatment given to patients with recurrent rectal cancer affects their well being and quality of life.
- Trial name
- NCT00648635
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- M.D. Anderson Cancer Center
Therapeutic Endoscopic Ultrasound, Advanced Endoscopy
Therapeutic Endoscopic Ultrasound for Gastrointestinal Disorders: A Multicenter Registry Study
The purpose of this retrospective chart-review registry study is to evaluate the safety profile, efficacy profile and cost-effectiveness of the various therapeutic endoscopic ultrasound (EUS) procedures (for benign and malignant…
- Conditions
- Therapeutic Endoscopic Ultrasound, Advanced Endoscopy, Therapeutic Endoscopy, Interventional Endoscopy
- Trial name
- TEUS Registry (NCT05051358)
- Testing
- Therapeutic Endoscopic Ultrasound
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Colorectal Cancer, Lynch Syndrome
Identifying Patients With Hereditary and Familial Colorectal Cancer by Using an Online Risk Tool
In this trial the investigators will evaluate the effectiveness of the implementation of a digital familial risk questionnaire in the detection of CRC patients with hereditary or familial CRC.
- Conditions
- Colorectal Cancer, Lynch Syndrome, Familial Colorectal Cancer
- Trial name
- FR-QUENT (NCT02645084)
- Testing
- Offering an online risk assessment questionnaire
- Volunteers
- 104 people
- Sponsor
- Prof. Evelien Dekker, MD, PhD
Chronic Myeloproliferative Disorders, Leukemia
Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment
RATIONALE: Antiemetic drugs, such as ondansetron, may help to reduce or prevent nausea and vomiting in patients with advanced cancer.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00006348
- Testing
- ondansetron
- Where
- 12 sites in United States
- Volunteers
- 100 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Colorectal Cancer, Metastatic Cancer
Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.
- Trial name
- NCT00006050
- Testing
- FOLFOX regimen, fluorouracil, isolated perfusion
- Where
- 3 sites in France
- Sponsor
- UNICANCER
Colon Cancer, Rectal Cancer
Exploratory Study Of The ERCC-1 Gene
This study is for patients with advanced or stage II and III colon or rectal cancer. The primary purpose of this research study is to determine if a particular protein in the patient's blood will change when they receive…
- Trial name
- NCT00846482
- Testing
- Oxaliplatin
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Albert Einstein College of Medicine
Colorectal Cancer
Improving Outcomes for Patients Requiring Oral Bowel Preparation for Colonoscopy
Study hypothesis The overall aim of this study is to compare two bowel preparations that are used prior to a colonoscopy procedure. The principal research questions are: 1.
- Trial name
- NCT00693290
- Testing
- low residue diet
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Ulster
Colorectal Neoplasms
A Single Arm, Open-label Clinical Trial to Evaluate the Efficacy and Safety of Maintenance Treatment With Capecitabine Plus Cetuximab in Metastatic Colorectal Cancer
This is a single arm, open-label, multi-center clinical trial to evaluate the efficacy and safety of maintenance treatment with capecitabine plus cetuximab after first-line 5-fluorouracil-based chemotherapy plus cetuximab for…
- Trial name
- NCT02717923
- Testing
- maintenance treatment with capecitabine plus cetuximab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huazhong University of Science and Technology
Rectal Cancer
ArtiSential® for Rectal Cancer Surgery
This study aimed to assess efficacy of ArtiSential® in reducing laparoscopic rectal cancer surgery duration. We retrospectively reviewed the data of patients who underwent laparoscopic low or ultralow anterior resection for…
- Trial name
- NCT06236282
- Testing
- ArtiSential®
- Where
- South Korea
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Familial Adenomatous Polyposes, Duodenal Polyposis
Endoscopic Evaluation of Duodenal Polyposis in Patients With Familial Adenomatous Polyposis (FAP)
Familial adenomatous polyposis (FAP) is an autosomal dominant genetic disorder that predisposes to a number or malignant disorders [1,2].
- Conditions
- Familial Adenomatous Polyposes, Duodenal Polyposis, Duodenal Cancer
- Trial name
- NCT03346980
- Testing
- Esophagogastroduodenoscopy
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Rectal Neoplasms
Choice of the Optimal Treatment Strategies for Mid-low REctal Cancer
The purpose of this study is to compare the efficacy, prognosis, health economics of different treatment modalities of mid-low rectal cancer in different centers in China, and to conduct cost utility analysis (CUA) on the…
- Trial name
- COMREC (NCT05871762)
- Testing
- Registry study, no specific intervention
- Where
- China
- Volunteers
- 3,705 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer, Liver Metastases
Prognostic Factors and Oncological Outcomes in Laparoscopic Liver Resection for CRLM
Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR).
- Conditions
- Colorectal Cancer, Liver Metastases, Surgery
- Trial name
- NCT05036265
- Volunteers
- 200 people
- Sponsor
- General Hospital Groeninge
Colon Cancer
Endoscopic Therapy Or Surgery for Early Colon Cancer
The trial is a randomized head-to-head comparison of the benefits, harms and burdens of endoscopic full-thickness resection (eFTR), a novel, minimally invasive endoscopic treatment modality, for early colon cancer as compared to…
- Trial name
- ETHOS (NCT06940947)
- Testing
- eFTR, Surgery
- Where
- Poland
- Volunteers
- 434 people
- Sponsor
- Norwegian Department of Health and Social Affairs
Hepatic Cancer, Pancreatic Ductal Cancer
The Natural History of Solid Organ Cancer Stem Cells (SOCSC)
Background: Researchers are trying to learn what causes certain types of cancer to spread to other organs in the body (metastasis).
- Conditions
- Hepatic Cancer, Pancreatic Ductal Cancer, Colorectal Cancer, Breast Cancer
- Trial name
- NCT00923052
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- National Cancer Institute (NCI)
Colon Cancer
Prognostic Molecular and Environmental Factors in High-Risk Colon Cancer Patients
The goal of this research study is to identify biologic and lifestyle factors that may increase a person's risk of developing a recurrence (return) of colon cancer.
- Trial name
- NCT00354705
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- M.D. Anderson Cancer Center