Clinical trials: Intracranial CNS Disorder
Brain Tumors, Non-CNS Malignancies
Prospective Assessment of Quality of Life (QOL) in Pediatric Patients Treated With Radiation Therapy for Brain Tumors and Non-central Nervous System (Non-CNS) Malignancies
In recent years, remarkable advances in medical oncology, surgery, and radiology have allowed for increasing cure rates for childhood malignancies.
- Trial name
- NCT01115777
- Testing
- Quality of Life surveys completed at specified timepoints
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Massachusetts General Hospital
Stroke
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosome Intranasal Instillations for Stroke
This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Stroke
- Trial name
- NCT05158101
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 15 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Photosensitive Epilepsy
Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25).
Sunflower Syndrome (also referred to as Self-induced Photosensitive Epilepsy) is a rare epileptic disorder characterized by a distinctive seizure that manifests itself in a highly stereotyped physical behavior.
- Trial name
- NCT03790137
- Testing
- Fenfluramine Hydrochloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Elizabeth Anne Thiele
Refractory Epilepsy, SYNGAP1 Encephalopathy
Fenfluramine for the Treatment of Different Types of Developmental and Epileptic Encephalopathies: a Pilot Trial Exploring Epileptic and Non-epileptic Outcomes
This study is a pilot non-controlled clinical trial with adjunctive fenfluramine for the treatment of five different types of developmental and epileptic encephalopathies (DEEs) focused on epileptic and "non-epileptic outcomes"…
- Conditions
- Refractory Epilepsy, SYNGAP1 Encephalopathy, STXBP1 Encephalopathy With Epilepsy, Inv Dup(15) Encephalopathy
- Trial name
- FENDEEP (NCT05232630)
- Testing
- Fenfluramine
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Ruber Internacional
Epilepsy
Valproate Dose Reduction and Its Clinical Evaluation by Introducing Lamotrigine in Japanese Women With Epilepsy - Single Arm, Multicenter, and Open-label Study
The purpose of this study is to examine whether the VPA (Valproate) dose can be reduced by additional administration of LTG (Lamotrigine) in Japanese pre-menopausal female epilepsy patients aged 15 years or older, whose seizures…
- Trial name
- NCT02100644
- Testing
- Lamotrigine tablets 25/100 mg
- Where
- 7 sites in Japan
- Volunteers
- 33 people
- Sponsor
- GlaxoSmithKline
Hypothermia, Trauma
Meta-Analysis Accidental Hypothermia in Trauma
This is a systematic literature review and meta-analysis investigating the effect of accidental hypothermia on mortality in trauma patients overall and patients with TBI specifically.
- Conditions
- Hypothermia, Trauma, Brain Injuries, Traumatic, Morality
- Trial name
- NCT04332237
- Where
- Switzerland
- Volunteers
- 776,684 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke
Women's Estrogen for Stroke Trial (WEST)
To determine if estrogen hormone replacement therapy reduces the risk of stroke or death in postmenopausal women who have already had stroke or a transient ischemic attack (TIA).
- Trial name
- NCT00026039
- Testing
- estrogen
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypoxic Encephalopathy
Early Neurological Outcome in Newborns With Mild Encephalopathy:a Regional Network
This is a multicenter prospective observational study that aims to determine the natural history of patients with early diagnosis (within 6 hours of life) of mild hipoxic ischemic encephalopaty (HIE), who are not candidates for…
- Trial name
- NCT05785481
- Testing
- Clinical and instrumental neurological assessment
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Tic Disorder, Chronic Motor or Vocal, Tourette Syndrome in Children
Evaluation of a Cognitive Psychophysiological Treatment for Tourette Syndrome and Tic Disorders
It is a randomized controlled trial to compare two behavioural treatments, namely CBIT and CoPs. This study would be the first head-to-head randomized trial between two established treatments rather than supportive counseling or…
- Conditions
- Tic Disorder, Chronic Motor or Vocal, Tourette Syndrome in Children, Tourette Syndrome
- Trial name
- NCT03225430
- Testing
- Cognitive behavioural treatment for tics, Cognitive psychophysiological
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Brain Injuries, Focal
VR Versus Task-Oriented Circuit Training on UL Sensorimotor in Children With Immature Brain Injury
To investigate and compare the effect of virtual reality and task-oriented circuit training on pinch grip and quality of life in children with with immature brain injury.
- Trial name
- NCT07827365
- Testing
- Virtual reality, Task-oriented circuit training
- Volunteers
- 44 people
- Sponsor
- October 6 University
Cerebral Palsy
Effects of Trunk Training in Patients With Cerebral Palsy
The aim of our study is to compare the effects of NGT-based trunk training, video-based trunk training and video-based trunk training applied with Theratogs in children with hemiparetic type Cerebral Palsy.
- Trial name
- NCT04516265
- Testing
- neurodevelopmental treatment, video-based trunk training, Video-based trunk training will apply with Theratogs
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Okan University
Polycystic Ovary Syndrome
The Relationship of PRL and Polycystic Ovary Syndrome (PCOS) in Taiwan's Women
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of reproductive-age women. According to Rotterdam 2003 criteria: at least two of three criteria are met, hyperandrogenism, chronic anovulation, and…
- Trial name
- NCT01117272
- Where
- Taiwan
- Volunteers
- 474 people
- Sponsor
- Taipei Medical University WanFang Hospital
Cerebral Palsy
Cell Therapy as Treatment for Cerebral Palsy
The purpose of this study was to study the effect of autologous bone marrow mononuclear cells on common symptoms of cerebral palsy patients.
- Trial name
- NCT02241395
- Testing
- Intrathecal autologous bone marrow mononuclear cell transplantation
- Where
- India
- Sponsor
- Neurogen Brain and Spine Institute
Cognitive Function 1, Social
Social Cognition Assessment in Young Adults
The primary objective of this study is to determine the efficacy and feasibility of a battery of neuropsychological measures evaluating social cognition and behavior in young adults diagnosed with schizophrenia, autism spectrum…
- Trial name
- NCT02922400
- Testing
- Social Cognition Assessment and Training
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Primary Dystonia, Epilepsy
Assess Specific Kinds of Children Challenges for Neurologic Devices Study
The ASK CHILDREN study is intended to aid in future development of various neurologic devices (i.e. neuroprostheses). The ASK CHILDREN study seeks to use study information obtained to identify more efficient strategies in the…
- Conditions
- Primary Dystonia, Epilepsy, Hydrocephalus, Bladder Control
- Trial name
- NCT01191307
- Volunteers
- 16 people
- Sponsor
- Carlos Pena, PhD, MS
PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Postural Balance
Telerehabilitation Versus Face-to-Face LSVT BIG in Individuals With Parkinson Disease
This prospective, randomized controlled trial will enroll 40 individuals with idiopathic PD (Hoehn \& Yahr stages 1-3, MoCA ≥21).
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Postural Balance, Parkinson Disease
- Trial name
- NCT07630792
- Testing
- Face-to-Face LSVT BIG, Telerehabilitation LSVT BIG
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Concussion
Driving Performance of Teenage Patients With mTBI: a Longitudinal Assessment
This study will synthesize a behavioral profile of impaired driving performance for teenage patients with mild traumatic brain injury (mTBI), or concussion, from one week post-concussion to six weeks post-concussion.
- Trial name
- NCT02278029
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cerebral Palsy, Hemiplegia
Effect of Coordinative Locomotor Training in Children With Cerebral Palsy
Cerebral palsy is a brain disorder that affects how children move their bodies. Children with spastic hemiplegic CP have stiffness on one side of the body, making it hard to walk and balance.
- Conditions
- Cerebral Palsy, Hemiplegia, Spastic cp
- Trial name
- CLT-PHYSIO-CP (NCT07651995)
- Testing
- Coordinative Locomotor Training, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Faisalabad
Antiplatelet Therapy, Hemorrhagic Infarction
Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)
Previous study showed that the proportions of hemorrhagic Infarction after intravenous thrombolysis were 24.2% and 32.5% in the control group and the alteplase group, and most of them were asymptomatic.
- Trial name
- NCT04624295
- Testing
- Early aspirin Therapy, Non-Early aspirin Therapy
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebral Palsy
HABIT-ILE in Infants and Toddlers With Cerebral Palsy (Baby HABIT-ILE)
Using a randomized controlled trial design, the possible changes induced by the intensive treatment programme "Hand-arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)" in functional, everyday life activities…
- Trial name
- Baby HABIT-ILE (NCT04698395)
- Testing
- Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE), Regular care
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.