Clinical trials: Intractable Epilepsy
Epilepsy, Epilepsy Intractable
Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy
The purpose of this study is to obtain preliminary data in advance of a larger clinical trial aimed to test whether a single session of green light exposure can lead to a clinically significant reduction in epileptic spikes in…
- Trial name
- NCT03857074
- Testing
- Green Light Exposure
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Refractory Epilepsy
Randomized Controlled Trial on Cardiovascular Exercise in Uncontrolled Epilepsy:
This is an open-label randomized controlled tria testing if an improvement in cardiovascular fitness can improve quality of Life and reduce seizure frequency in patients with refractory epilepsy..
- Trial name
- Epilepsy (NCT03570489)
- Testing
- Exercise, Relaxation
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Vastra Gotaland Region
Epilepsy; Seizure
Deep Brain Stimulation vs. Vagus Nerve Stimulation for Epileptic Spasms
Deep Brain Stimulation vs. Vagus Nerve Stimulation for the Treatment of Drug-Resistant Epilepsy and Epileptic Spasms in Children: A Randomized Control Trial
- Trial name
- DBS-VNS-ES (NCT07010276)
- Testing
- DBS Arm, VNS arm
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Infantile Spasms
Short-term Ketogenic Diet as Compared With Conventional Long-term Trial in Refractory Infantile Spasms: A Randomized, Controlled Study
This is a randomized, controlled study to compare Short-term ketogenic diet with conventional long-term trial in refractory infantile spasms.
- Trial name
- NCT00968136
- Sponsor
- Yonsei University
Epilepsy
Intracerebral Electrical Stimulation and the Optimisation of Presurgical Planning in Drug-refractory Partial Epilepsy
Patients with drug-refractory epilepsy sometimes need to be implanted with intracerebral electrodes in order to identify their seizure onset zone.
- Trial name
- StiMiC (NCT03738072)
- Testing
- StiMiC stimulation condition
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Epilepsy, Focal
A Study of Brivaracetam in Subjects With Partial Onset Seizures
This trial will evaluate the efficacy and safety of brivaracetam (at doses of 50 and 150 mg/day in twice a day administration) as add on therapy in subjects with focal epilepsy
- Trial name
- NCT00175929
- Testing
- Brivaracetam
- Where
- 56 sites in Belgium, Czechia and 7 more
- Volunteers
- 157 people
- Sponsor
- UCB Pharma
Refractory Partial Onset Seizures
Open-Label Extension Study of Rufinamide Given as Adjunctive Therapy in Patients With Refractory Partial Seizures
This was an open-label extension study in adolescent and adult (between 12 and 80 years old) participants who had completed their participation in Study E2080-A001-301.
- Trial name
- NCT00448539
- Testing
- Rufinamide
- Where
- 27 sites in United States
- Volunteers
- 286 people
- Sponsor
- Eisai Inc.
Drug Resistant Epilepsy
Real-World Study of Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-resistant Epilepsy
The goal of the real-world study is to evaluate the long-term seizure control outcomes, postoperative complications, long term impact on cognitive, memory function outcomes, quality-of-life measures, and healthcare resource…
- Trial name
- NCT06341075
- Testing
- Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Seizures, Epilepsies, Partial
Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures.
To evaluate the efficacy and safety of diazepam in the management of refractory epilepsy in selected patients who require intermittent medical intervention for the control of episodes of acute repetitive seizures.
- Conditions
- Seizures, Epilepsies, Partial, Epilepsy, Complex Partial, Epilepsy, Generalized
- Trial name
- NCT00319501
- Testing
- Vanquix Auto-Injector (Diazepam Injection)
- Where
- 86 sites in United States
- Volunteers
- 234 people
- Sponsor
- Pfizer
Refractory Childhood Epilepsy
Modified Atkins Diet in Childhood Epilepsy
Seizures are a frequent cause of morbidity in the pediatric age group. Uncontrolled seizures pose a variety of risks to children, including higher rates of mortality, developmental delay and/or regression, and cognitive…
- Trial name
- mAD (NCT00836836)
- Testing
- Modified Atkins diet
- Where
- India
- Volunteers
- 96 people
- Sponsor
- All India Institute of Medical Sciences
Epilepsy, Drug Resistant Epilepsy
Ketonemia Through Menstrual Cycle
Ketogenic dietary therapies (KDTs) are well-established, safe, non-pharmacologic treatments used for children and adults with drug-resistant epilepsy and other neurological disorders.
- Conditions
- Epilepsy, Drug Resistant Epilepsy, GLUT1DS1, Ketogenic Dieting
- Trial name
- KETOMENS (NCT05234411)
- Testing
- Evaluation of ketogenic diet impact on ketonemia
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Pavia
Epilepsy, Refractory
Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy
- Trial name
- NeuroSeizure (NCT05254730)
- Testing
- macro-micro tetrodes for intracranial recording
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Adrien Peyrache
Refractory Epilepsy
Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Refractory Epilepsy
Evaluate the long-term clinical effectiveness and safety of the PINS Deep Brain Stimulation to patients with refractory epilepsy.
- Trial name
- ANT-DBS-RE (NCT02602899)
- Testing
- PINS'Deep Brain Stimulator device
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Spasms, Infantile, Epilepsy
Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment
OBJECTIVES: I. Evaluate the efficacy of surgical resection of an identifiable zone of cortical abnormality versus multiple drug therapy in children with infantile spasms refractory to standard therapy. II.
- Trial name
- NCT00004758
- Testing
- carbamazepine, corticotropin, nitrazepam
- Volunteers
- 30 people
- Sponsor
- National Center for Research Resources (NCRR)
Intractable Epilepsy
Ketogenic Diet Drink Study
An evaluation of the tolerance, compliance, acceptability and safety of a nutritionally complete liquid feed for use as part of the ketogenic diet (KD) in children 8+ years, adolescents and adults with intractable epilepsy or…
- Trial name
- NCT03196271
- Testing
- Ketocal 2.5:1
- Where
- 9 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- Nutricia UK Ltd
Partial Epilepsy
Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) as Adjunctive Therapy for Refractory Partial Seizures
The purpose of this study is to determine whether Eslicarbazepine acetate (BIA 2-093) is an effective adjunct therapy in the treatment of refractory partial seizures
- Trial name
- NCT00988429
- Testing
- 800 mg QD Eslicarbazepine acetate, 1200 mg QD Eslicarbazepine acetate
- Where
- 162 sites in United States, Argentina and 9 more
- Volunteers
- 653 people
- Sponsor
- Bial - Portela C S.A.
Ketogenic Diet, Drug Resistant Epilepsy
Effects of Low Glycemic Index Diet in Children With Drug-resistant Epilepsy
The goal of this clinical trial was to evaluate the effectiveness of a low glycemic index diet (LGID) on seizure frequency, oxidative stress markers and quality of life in children with drug-resistant epilepsy.
- Conditions
- Ketogenic Diet, Drug Resistant Epilepsy, Oxidative Stress, Quality of Life
- Trial name
- NCT06432231
- Testing
- Low glycemic index diet treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Izmir Katip Celebi University
Epilepsy
Cannabinoid Therapy for Pediatric Epilepsy
This is a Phase 1 trial to determine the tolerability and optimal dose of CBD rich cannabis extract as an adjunct treatment in children with severe drug resistant epilepsy due to Dravet Syndrome.
- Trial name
- NCT02983695
- Testing
- TIL-TC150
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Epilepsy, Epilepsy, Temporal Lobe
Surgery as a Treatment for Medically Intractable Epilepsy
Background: Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT01273129
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Refractory Epilepsy in Children, Refractory Epilepsy
Cannabidiol as add-on Therapy for Children With Refractory Epilepsy (CBD-uN1que), a High-quality Individualized Approach: a Series of N-of-1 Trials
The goal of this clinical trial is to learn if cannabidiol ("CBD-oil") works to treat severe epilepsy in children. It will also learn about the safety of cannabidiol.
- Conditions
- Refractory Epilepsy in Children, Refractory Epilepsy, Epilepsy
- Trial name
- CBD-uN1que (NCT07668856)
- Testing
- Cannabidiol (CBD) oral solution
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht