Clinical trials: Intranasal Administration
Anxiety, Lacerations
Intranasal Midazolam for Treatment of Anxiety in Children Undergoing Suturing in the Pediatric Emergency Department
Laceration repair can cause significant anxiety in children. As open wounds account for 21-25% of injuries in children presenting to the emergency department, the management of anxiety is of great importance.
- Trial name
- NCT02618772
- Testing
- Midazolam, Saline
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Anesthesia
Safety and Pharmacokinetics of Kovacaine Nasal Spray in Pediatric Subjects
The purpose of this study is to determine the pharmacokinetics and safety of a nasal spray containing the anesthetic drug Tetracaine in combination with Oxymetazoline in healthy pediatric subjects.
- Trial name
- NCT01952990
- Testing
- Tetracaine HCl 3% and Oxymetazoline HCl 0.05%
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- St. Renatus, LLC
Newborn; Vitality, Nursing Caries
Effect of Intranasal Breast Milk Administration in Preterm Infants
The aim of the study was to investigate the effect of intranasal breast milk administration on cerebral oxygenation level, vital signs and time to full oral feeding in preterm infants.
- Conditions
- Newborn; Vitality, Nursing Caries, Breast Feeding
- Trial name
- NCT06706115
- Testing
- Intranasal human breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Headaches
RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches
Background : Headaches are a common presentation for children consulting to the Emergency Department (ED). However, only few studies have evaluated the rapid pain improvement provided by medications in the acute management of…
- Trial name
- NCT02638506
- Testing
- Fentanyl, Salinex
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Asthma, Allergic Rhinitis
Evaluation of the Animated Cartoon-aided Teaching of Intranasal Corticosteroid Allergic Rhinitis
Correct methods and compliance of intranasal corticosteroid (INCS) is very important for the treatment of allergic rhinitis (AR).
- Trial name
- NCT02571413
- Testing
- score before teaching, score immediately after teaching, score 3 months after teaching
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nualanong Visitsunthorn
Influenza
Home Administration of FluMist by Parents/Caregivers
This study will examine the feasibility of having parents and caregivers administer FluMist live intranasal vaccine to their children at home outside the traditional medical environment and without the involvement of medical…
- Trial name
- NCT01938170
- Testing
- FluMist
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Migraine in Children, Posttraumatic Headache
A Pilot Study of Intranasal Lidocaine in Acute Management of Pediatric Migraine
Headaches in children are very common and are a source of significant distress for the patient and their family. Migraines are the most common headache disorder in children and are associated with episodic pain and other symptoms…
- Trial name
- NCT03806595
- Testing
- Lidocaine 2% Injectable Solution, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Morphinan Opioid Overdose
Randomized Trial of Intranasal Versus Intravenous Naloxone in Level of Consciousness in Suspected Opioid Overdose
The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients
- Trial name
- NCT01293058
- Testing
- Intranasal naloxone, Intravenous
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Laceration of Skin, Anxiety
IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED
Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to optimize patient and family experience and allow for…
- Conditions
- Laceration of Skin, Anxiety, Discharge Time
- Trial name
- NCT05934669
- Testing
- Intranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Staphylococcal Aureus Infection, Microbial Colonization
Administering NMT to Reestablish Infant Nasal Microbiome Diversity Following Intranasal Mupirocin Treatment
This protocol aims to evaluate how NMT affects pediatric nasal microbiome diversity following intranasal mupirocin treatment
- Conditions
- Staphylococcal Aureus Infection, Microbial Colonization, Pediatric Infection, S. Aureus Colonization
- Trial name
- NMT Protocol 3 (NCT06805994)
- Testing
- Nasal Microbiota Transplant (NMT)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dental Anxiety in Children, Child Behaviour
Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide Monotherapy
The rationale of this trial is to evaluate whether combining intranasal atomized midazolam with nitrous oxide offers better behavior management leading to successful treatment completion in comparison with using nitrous oxide…
- Trial name
- NCT07876024
- Testing
- Midazolam (Intranasal), Nitrous oxide/oxygen inhalation sedation alone
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Autism Spectrum Disorder
Intranasal Ketamine With Dexmedetomidine for the Treatment of Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a life-long neurodevelopmental disorder characterized by qualitative abnormalities in reciprocal social interactions and patterns of communication, and by a restricted, stereotyped, repetitive…
- Trial name
- NCT03434366
- Testing
- ketamine and dexmedetomidine, ketamine, Saline
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Preoperative Anxiety, Emergence Agitation
Effects of Nasal Administration of Dexmedetomidine on Pre-anesthesia Sedation, Intraoperative Brain Electrical Activity, and Incidence of Agitation During Recovery in Children
Pre - operative anxiety and emergence agitation are common issues among pediatric patients, which have various influences on the recovery progress and prognosis of children.
- Trial name
- NCT06896721
- Testing
- Preoperative sedation with dexmedetomidine was administered nasal before surgery, Preoperative sedation with normal saline was administered nasal before surgery
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Fuzhou Hua
Pain
Efficacy of Topical Lidocaine to Decrease Discomfort With Intranasal Midazolam Administration
The purpose of this study was to establish whether premedication with topical lidocaine would reduce the pain associated with IN midazolam administration in children.
- Trial name
- NCT02396537
- Testing
- Lidocaine, Midazolam, 0.9% Saline
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Influenza
Safety Study of Freeze-dried Live Attenuated Influenza Vaccine for Intranasal Administration in Chinese Adults Aged 3 Years and Older
This study evaluates the safety of freeze-dried live attenuated influenza vaccine for intranasal administration in chinese adults aged 3 years and older.80 subjects will be divided into 2 groups, including 18 years and older and…
- Trial name
- NCT02665871
- Testing
- one dose of Influenza Vaccine
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beijing Chaoyang District Centre for Disease Control and Prevention
Child Behavior, Dental Caries
Midazolam and Ketamine Effect Administered Through the Nose for Sedation of Children for Dental Treatment
Randomised clinical trial to test the efficacy, safety and cost-effectiveness of sedatives; masked, controlled, parallel design with three arms, phase 4.
- Trial name
- NASO (NCT02447289)
- Testing
- Intranasal ketamine, Oral ketamine, Intranasal midazolam
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias