Clinical trials: Intraocular Pressure (IOP)
Posterior Capsule Opacification, Ocular Hypertension
Brinzolamide/Brimonidine Combination vs Brimonidine 0.2% in the Prevention of IOP Rise After Nd-YAG Laser Capsulotomy
To compare the efficacy of a Brinzolamide/Brimonidine fixed combination (FC) with Brimonidine 0.2% in preventing intraocular pressure (IOP) elevations after neodymium: yttrium-aluminum-garnet (Nd:YAG) laser posterior capsulotomy.
- Trial name
- NCT03192826
- Testing
- Brinzolamide/Brimonidine FC, Brimonidine 0.2%, Artificial tears
- Where
- Greece
- Volunteers
- 79 people
- Sponsor
- University Hospital of Patras
Ocular Hypertension, Open-angle Glaucoma
Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension
Evaluation of the ocular hypotensive efficacy and safety of Netarsudil (AR-13324) Ophthalmic Solution compared to Timolol Maleate Ophthalmic Solution
- Trial name
- NCT02207621
- Testing
- AR-13324 Ophthalmic Solution 0.02%, Timolol maleate Ophthalmic Solution 0.5% BID, AR-13324 Ophthalmic Solution 0.02% BID
- Where
- United States
- Volunteers
- 756 people
- Sponsor
- Aerie Pharmaceuticals
Glaucoma, Intraocular Pressure
Comparing Rates of Glaucoma in Professional Wind Versus Non-Wind Instrument Players
The purpose of the present study is to compare rates of glaucomatous optic neuropathy in professional wind versus non-wind instrument players in the Philadelphia Orchestra.
- Conditions
- Glaucoma, Intraocular Pressure, Optic Neuropathy
- Trial name
- NCT02612571
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Wills Eye
Glaucoma, Intraocular Pressure
Assessment of Home Tonometry in Glaucoma
Worldwide, glaucoma is the most common cause of irreversible blindness. The major risk factor is raised pressure within the eye (intraocular pressure, IOP). IOP is typically measured using Goldman applanation tonometry (GAT).
- Trial name
- NCT03057301
- Testing
- iCare home tonometer
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- NHS Lothian
Prostate Cancer
Effects of PEEP on Intracranial and Intraocular Pressure in Robot-assisted Laparoscopic Radical Prostatectomy
To investigate the effects of positive end-expiratory pressure (PEEP) on the intracerebral pressure (ICP) and intraocular pressure (IOP) in patients undergoing robot assisted laparoscopic radical prostatectomy (RALRP)
- Trial name
- NCT03031613
- Testing
- PEEP group, ZEEP group
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Glaucoma
Effectiveness of a Procedure for Previously Failed Glaucoma Surgery
Transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to treat cases with a previously failed trabeculectomy. We will investigate approximately 100 consecutive cases with follow up of up to 9 years.
- Trial name
- NCT00347789
- Testing
- Glaucoma surgery- Bleb revision
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Glaucoma
Alcon Hydrus Stent Implantation - Long Term Follow up After 8 Years
The purpose of this study is to evaluate the long-term effectiveness and safety of the Hydrus implant combined with concomitant phacoemulsification for lowering intraocular pressure (IOP).Glaucoma patients often have high…
- Trial name
- NCT07460791
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Johannes Gutenberg University Mainz
Pigmentary Dispersion Syndrome, Pigmentary Dispersion Glaucoma
IOP Reduction in Pigmentary Glaucoma Using DSLT
This study is a single-site, single-arm, prospective, observational study of IOP reduction after DSLT. Subjects will be assessed up to 12 months post-operatively.
- Trial name
- NCT07281391
- Testing
- Voyager DSLT
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mann Eye Institute
Glaucoma, Open-Angle, Circadian Rhythm
Circadian Variations in Ocular Blood Flow in Glaucomatous and Normal Eyes
After focusing many years only on intraocular pressure (IOP) as the primary risk factor, recently the impact of ocular blood flow is getting more consideration for the pathophysiology of glaucoma.
- Conditions
- Glaucoma, Open-Angle, Circadian Rhythm, Intraocular Pressure, Regional Blood Flow
- Trial name
- NCT00707226
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Intraocular Pressure
External Influences Upon Ocular Homeostasis
Our experiments are designed to test the overall hypothesis that position-dependent or water-dependent intra-ocular pressure (IOP) spikes occur in humans, and that these challenge ocular homeostasis.
- Trial name
- NCT00338065
- Testing
- Postural change, Water drinking
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Mucopolysaccharidosis, Fabry Disease
Non-invasive Assessment of Intraocular Pressure in MPS by Use of the Ocular Response Analyzer.
The aim of the present study is to compare intraocular pressure (IOP) values assessed with Ocular Response Analyzer to the classical gold standard of IOP measurement, to Goldmann applanation tonometry by mucopolysacchyridosis…
- Trial name
- MPSORA (NCT01695161)
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Cleft Palate
Effect of Neck Extension on Intraocular Pressure in Patients Undergoing Palatoplasty
The purpose of this study is to investigate the change in intraocular pressure according to the neck extension during palatoplasty in pediatric patients.
- Trial name
- NCT04683978
- Testing
- Position
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Asan Medical Center
Primary Open Angle Glaucoma, Acupressure
Regulation of Intraocular Pressure in Glaucoma Patients by Acupressure
The purpose of this clinical trial is to implement acupressure twice daily and monitor the changes in intraocular pressure (IOP) in patients with different levels of glaucoma.
- Trial name
- NCT05898997
- Testing
- Acupressure
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Intraocular Pressure
Effect of Raised End-Tidal pCo2 on Choroidal Volume
This study is to investigate the relationship between arterial carbon dioxide (CO2) concentration and vitreous pressure on the choroidal volume by integrated intraoperative OCT imaging under eye exams under anesthesia.
- Trial name
- NCT06275308
- Testing
- Ventilation manipulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Ocular Hypertension, Open-angle Glaucoma
Double-masked Study of AR-13324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
To evaluate the ocular hypotensive efficacy and ocular and systemic safety of AR-13324 Ophthalmic Solution, 0.02% compared to the active comparator Timolol maleate Ophthalmic Solution, 0.5%
- Trial name
- Rocket-1 (NCT02207491)
- Testing
- Timolol maleate Ophthalmic Solution 0.5% BID, AR-13324 Ophthalmic Solution 0.02%
- Where
- United States
- Volunteers
- 411 people
- Sponsor
- Aerie Pharmaceuticals
Ocular Hypertension, Primary Open Angle Glaucoma
A Study of Ganfort Versus Duotrav in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
This is a single-center, cross-over comparison parallel group randomized trial designed to evaluate the efficacy and safety of Ganfort compared to Duotrav for a treatment period of 8 weeks each.
- Trial name
- NCT01168414
- Testing
- Ganfort, Duotrav
- Where
- Malaysia
- Volunteers
- 42 people
- Sponsor
- Ministry of Health, Malaysia
Open Angle Glaucoma
Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma
The purpose of this study is to evaluate the effectiveness of a new laser (called Micropulse Laser Trabeculoplasty or MLT) in the treatment of glaucoma compared to the conventional laser presently used which is called selective…
- Trial name
- NCT01956942
- Testing
- Micropulse Laser Trabeculoplasty, Selective Laser Trabeculoplasty
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- David Belyea
Post-Injection Intraocular Pressure Spikes
Pre-Administration of Brimonidine in Intravitreal Anti-VEGF Therapy
In this study, investigators will be examining the intraocular pressure lowering effect of brimonidine 0.15% when administered 20min prior to intravitreal anti-VEGF injection.
- Trial name
- NCT03513172
- Testing
- topical brimonidine tartrate 0.15% (Alphagan® P; Allergan, Inc)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Myopia, Anisometropia
Ocular Response Analyzer Assessment of Intraocular Pressure and Corneal Biomechanical Properties in Myopic and Anisometropic Patients Under Atropine Treatment
Our study has three parts has three parts, and the main aim of the study is to find out if corneal hysteresis was associated with myopia or even a predictor of myopia poor control predictor: Part 1 of our study: patients with…
- Trial name
- NCT00658502
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Anesthesia, Intraocular Pressure
Establishment of an Anaesthetic Protocol for Examinations for Children With Glaucoma or Suspected Glaucoma
Correct measurement of the intraocular pressure of children with glaucoma or suspected glaucoma is essential for diagnosis and therapy.
- Conditions
- Anesthesia, Intraocular Pressure, Glaucoma, Suspect, Pediatric Glaucoma
- Trial name
- eyeBIS (NCT03972852)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz