Clinical trials: Invasive Mechanical Ventilation
Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)
National Surveillance and Prevention of Neonatal VAP
The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD), Antibiotic-Resistant Organisms (AROs), Health-Care Associated Infection (HAI)
- Trial name
- NCT07109791
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Invasive Mechanical Ventilation, Critical Illness
Mechanical Ventilation Discontinuation Practices
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Conditions
- Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation
- Trial name
- IOS (NCT03955874)
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,868 people
- Sponsor
- Unity Health Toronto
Respiration, Artificial
Patient-ventilator Asynchrony During Mechanical Invasive Assisted-ventilation in Pediatric Patients
The purpose of this study is to document the prevalence and type of asynchronies incidence during invasive mechanical ventilation in pediatric patients breathing under pressure support.
- Trial name
- NavPed-Inv (NCT01193023)
- Testing
- Pressure Support, NAVA
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Geneva
Respiratory Distress Syndrome (RDS), Newborn
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates
The goal of this clinical trial is to learn if nasal high frequency oscillatory ventilation (nHFOV) works no worse than nasal intermittent mandatory ventilation (NIMV) as early breathing support.
- Conditions
- Respiratory Distress Syndrome (RDS), Newborn, Premature Birth
- Trial name
- NOV-RDS (NCT07837141)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Aga Khan University
Mechanical Ventilation, Pain
Skin Conductance in Ventilated Preterms
The goal of this observational study is to learn more about the pain and stress experienced by newborn infants receiving mechanical ventilation (breathing through a machine).
- Conditions
- Mechanical Ventilation, Pain, Skin to Skin Care, Kangaroo Mother Care
- Trial name
- SCiP (NCT07568418)
- Testing
- Skin Conductance Measurement
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University Hospital
Acute Respiratory Distress Syndrome (ARDS), Ventilator Management
Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial
Acute respiratory distress syndrome (ARDS) is a serious and potentially life-threatening lung condition that can affect children.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Ventilator Management, Lung-protective Ventilation, Pediatric Acute Respiratory Distress Syndrome (PARDS)
- Trial name
- PARMA (NCT07123961)
- Testing
- High Driving Pressure Mechanical Ventilation, Low Driving Pressure Mechanical Ventilation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Children's Hospital of Philadelphia
Position on Premature Infants, Nursing Care
The Effect of Positioning on Comfort, Stress Levels, and Physiological Functions in Premature Infants
A randomized crossover study was made to investigate the effect of different positions on the comfort, stress, and physiological functions of premature infants receiving non-invasive mechanical ventilation in the neonatal…
- Trial name
- NCT06752005
- Testing
- Intervention Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Aydin Adnan Menderes University
Mechanical Ventilation Complication, Pediatric Respiratory Diseases
Tracheal Suctioning With or Without Expiratory Pause Maneuver in Children
The purpose of this study is to evaluate the efficacy of tracheal suctioning associate with expiratory pause maneuver in children on invasive mechanical ventilation.
- Trial name
- NCT05805475
- Testing
- Endotracheal suctioning with expiratory pause, Endotracheal suctioning without expiratory pause
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Mechanical Ventilator Weaning, Critically Ill
Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: Will weaning with neurally adjusted ventilatory assist (NAVA) mode…
- Conditions
- Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
- Trial name
- NCT06157593
- Testing
- NAVA
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Neuromuscular Diseases (NMD), ALS (Amyotrophic Lateral Sclerosis)
Invasive Home Ventilation in Denmark
The aim of this study is to describe national trends over the past 10 years in patients receiving invasive home mechanical ventilation (HMV) in Denmark.
- Conditions
- Neuromuscular Diseases (NMD), ALS (Amyotrophic Lateral Sclerosis), Spinal Cord Injuries (SCI), Duchenne Muscular Dystrophy (DMD)
- Trial name
- HOMEVENT DK (NCT07467187)
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Critically Ill
The Frequency of Screening and SBT Technique Trial: The FAST Trial
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing.
- Trial name
- NCT02969226
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 17 sites in United States, Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
Tracheal Intubation
Flow Sensor and Colourimetric Capnometer in Verifying Tracheal Tube Positioning in Term and Preterm Infants
This is a multicentre clinical trial with medical device. As currently recommended by international neonatal resuscitation guidelines, the most reliable method to verify the correct positioning of the endotracheal tube, in…
- Trial name
- FlowNET (NCT05162313)
- Testing
- confirmation of endotracheal tube positioning
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pediatric Respiratory Diseases, Bronchiolitis
Assessment of NeuroBOX and NeuroPAP in Infants.
Non-invasive ventilation (NIV, delivered via a mask or cannulas) permits to reduce the need for tracheal intubation in infants who needs a ventilatory support.
- Conditions
- Pediatric Respiratory Diseases, Bronchiolitis, Infant Respiratory Distress Syndrome
- Trial name
- NeuroPap2 (NCT03650478)
- Testing
- NeuroPAP ventilation (2h) and NeuroBox monitoring (23h), NeuroPAP ventilation (4h) and NeuroBox monitoring (25h)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Neonatal Respiratory Failure, Invasive Mechanical Ventilation
A Model for Predicting Extubation Success in Premature Babies
Invasive mechanical ventilation is a life-saving treatment in critically ill newborns with respiratory failure. However, continuing this treatment for a long time may have negative consequences, especially bronchopulmonary…
- Conditions
- Neonatal Respiratory Failure, Invasive Mechanical Ventilation, Extubation Failure
- Trial name
- NCT05081973
- Testing
- A model for predicting extubation success based on extubation readiness estimator and lung ultrasonography score
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Marmara University
Ventilator-Associated Pneumonia Prevention and Intensive Care Nursing Care
Theory-Based Educational Program for VAP Prevention and Nursing Care in Intensive Care Units
Ventilator-associated pneumonia (VAP) is an important challenge in intensive care and requires nurses to apply evidence-based preventive practices consistently in mechanically ventilated patients.
- Trial name
- TSEP-VAP-2026 (NCT07820826)
- Testing
- Theory-Based Structured Educational Program, Usual Care
- Where
- Jordan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- JAWAD AHMAD ABU-SHENNAR
Ventilator Weaning
Home-based Optimization of Mechanical Ventilation in Children
Some children who are born very early or have other congenital conditions may develop severe, long-term lung problems that make them need to use a breathing machine to live at home.
- Trial name
- HOMVent4Kids (NCT06055413)
- Testing
- Remote patient monitoring (RPM) bundle
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Ventilator Weaning
Sedation and Weaning in Children Requiring Invasive Mechanical Ventilation
A UK multi-centre cluster randomised controlled trial to determine if a protocol-based intervention incorporating coordinated care with greater nursing involvement to managing sedation and ventilator weaning can reduce the…
- Trial name
- SANDWICH (NCT03673683)
- Testing
- SANDWICH protocol, Usual care
- Where
- 17 sites in United Kingdom
- Volunteers
- 10,498 people
- Sponsor
- Queen's University, Belfast
Invasive Mechanical Ventilation, Extubation
The External Diaphragm Pacemaker Assisted Extubation in Premature Infants With Invasive Mechanical Ventilation
With the development of perinatal medicine, more and more newborns with respiratory failure can be treated due to the use of respiratory support technology.
- Trial name
- NCT06404294
- Testing
- External Diaphragm Pacemaker treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Tricuspid Regurgitation, Mechanical Ventilation Pressure High
Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV)…
- Conditions
- Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
- Trial name
- NCT06229886
- Testing
- Application of positive-end-expiratory pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Chronic Obstructive Pulmonary Disease, Neuromuscular Disease
Telemedicine and Ventilator Titration in Chronic Respiratory Patients Initiating Non-invasive Ventilation
The critical nature of respiratory diseases, the continuously increasing prevalence of these conditions, and the subjective perception of patients vis-à-vis their pulmonary function and health status underscore the importance of…
- Conditions
- Chronic Obstructive Pulmonary Disease, Neuromuscular Disease, Chest Wall Disorders, Obesity Hypoventilation Syndrome
- Trial name
- TeleMotiNIV (NCT01560741)
- Testing
- Telemonitoring tools, Usual Care
- Where
- Portugal
- Volunteers
- 128 people
- Sponsor
- Hospital Sao Joao