Clinical trials: Jaundice
Neonatal Hyperbilirubinemia, Treatment Decisions
Bilirubin Thresholds in Preterm Infants on Neonatal Intensive CarE Units: The B-NICE Trial
Rationale: Neonatal hyperbilirubinemia is highly prevalent in very preterm infants born <30 weeks. Since 2008, uniform Dutch phototherapy thresholds for preterm infants have been used nationwide, largely based on consensus.
- Conditions
- Neonatal Hyperbilirubinemia, Treatment Decisions, Neurodevelopmental Outcome, Phototherapy
- Trial name
- B-NICE (NCT07674537)
- Testing
- Phototherapy, Exchange Transfusion
- Where
- Netherlands
- Volunteers
- 680 people
- Sponsor
- University Medical Center Groningen
Prematurity, Neonatal Encephalopathy
Evaluating the NeoTree in Malawi and Zimbabwe
Neonatal mortality remains unacceptably high. Globally, the majority of mothers now deliver in health facilities in low resource settings where quality of newborn care is poor.
- Conditions
- Prematurity, Neonatal Encephalopathy, Neonatal Sepsis, Neonatal Death
- Trial name
- NCT05127070
- Testing
- Neotree
- Where
- 5 sites in Malawi, Zimbabwe
- Volunteers
- 19,000 people
- Sponsor
- University College, London
Hyperbilirubinemia
Safety and Pharmacology of Stanate
The purpose of this study is to evaluate the effect and safety of Stanate (stannsoporfin) in infants who are at risk for an exchange transfusion and meet the criteria of the protocol.
- Trial name
- NCT00115544
- Testing
- Stanate
- Where
- Vietnam
- Volunteers
- 55 people
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Neonatal Jaundice
Role of Fenofibrate in Neonatal Jaundice
Fenofibrate appears to be an effective and safe drug for the treatment of neonatal hyperbilirubinemia. It has been proven that it decreases the duration of phototherapy and thus shortens the length of hospital stay.
- Trial name
- NCT06451900
- Testing
- Fenofibrate
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Jaundice, Neonatal
Transcutaneous Bilirubinometers in the Community
Jaundice is the most frequent reason for readmission for healthy newborns after discharge from the nursery. In the Capital Health area, around 2.5% (315 babies in 2005) of all healthy newborns were admitted to the hospital for…
- Trial name
- TcB RCT (NCT00735319)
- Testing
- Transcutaneous Bilirubinometer
- Where
- 6 sites in Canada
- Volunteers
- 10,000 people
- Sponsor
- University of Alberta
Newborn Jaundice, Hyperbilirubinemia, Neonatal
White Cover & Massage Effects on Bilirubin and Phototherapy in ABO-Incompatible Newborns
This study aims to examine the effect of white cover and massage application on bilirubin levels and phototherapy duration in newborns with ABO incompatibility receiving phototherapy.
- Conditions
- Newborn Jaundice, Hyperbilirubinemia, Neonatal, ABO Incompatibility, Newborn Massage
- Trial name
- NCT06921330
- Testing
- white cover-newborn massage
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Pancreatic Neoplasms, Biliary Tract Neoplasms
Comparing Endoscopic Based Stent Strategy Versus Bypass Surgery in Non-resectable Periampullary Cancer
Randomized study comparing endoscopic stent insertion strategy versus double-bypass surgery in non-resectable periampullary cancer
- Conditions
- Pancreatic Neoplasms, Biliary Tract Neoplasms, Duodenal Neoplasms
- Trial name
- NCT00487851
- Testing
- surgery, endoscopic strategy
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Hyperbilirubinemia
Implementation of a Clinical Decision Rule for Treatment of Neonatal Jaundice in the Emergency Department
Jaundice is a condition caused by elevated levels of bilirubin in the body otherwise known as hyperbilirubinemia. It occurs when there is an increase in bilirubin production or normal production with problems eliminating it from…
- Trial name
- NCT02446951
- Where
- 2 sites in United States
- Volunteers
- 925 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Hyperbilirubinemia, Neonatal, Jaundice, Neonatal
Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight
This multi-center, randomized clinical trial compared different bilirubin levels as thresholds for timing of phototherapy in extremely low birth weight infants.
- Conditions
- Hyperbilirubinemia, Neonatal, Jaundice, Neonatal, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- Phototherapy (NCT00114543)
- Testing
- Aggressive Phototherapy 501-750g, Aggressive Phototherapy 751-1000g, Conservative Phototherapy 501-750g
- Where
- 17 sites in United States
- Volunteers
- 1,974 people
- Sponsor
- NICHD Neonatal Research Network
Neonatal Jaundice
Reliability of Transcutaneous Bilirubin Measurement According to the Skin Colour of Newborns
Neonatal jaundice is a physiological process characterized by a yellow coloration of the skin and mucous membranes linked to an increase in a pigment: bilirubin.
- Trial name
- BILICOLOR (NCT07315126)
- Testing
- Skin color assessment
- Where
- France
- Volunteers
- 510 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris