Clinical trials: Jaw Abnormalities
Cleft Lip and Palate
Liposomal Bupivacaine Use in Alveolar Bone Graft Patients
The goal of this clinical trial is to learn if a pain medication called liposomal bupivacaine (brand name EXPAREL®) with epinephrine will provide better pain control, increased activity, and reduced use of opioids compared with…
- Trial name
- NCT06284434
- Testing
- Liposomal Bupivacaine, Bupivacain, Epinephrine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kerry O'Rourke
Cleft Palate
Repair of Oronasal Fistula Using Interpositional Buccal Pad of Fat as a Free Graft in a Cleft Palate Patient
36 cleft palate patients had residual oronasal fistula included in this study divided randomly to two groups group I (control group): the fistula was repaired using two layers (oral and nasal layers) group II (study group): The…
- Trial name
- NCT06807450
- Testing
- closure of oro-nasal fistula in cleft palate patients
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tanta University
Cleft Palate
Optic Nerve Sheath Diameter in Patients Undergoing Palatoplasty
The purpose of this study is to evaluate the change of the optic nerve sheath diameter according to the change of the neck position in pediatric patients undergoing palatoplasty.
- Trial name
- NCT03585608
- Testing
- Neck extension
- Where
- 2 sites in South Korea
- Volunteers
- 30 people
- Sponsor
- Asan Medical Center
Cleft Lip, Cleft Palate
Systematic Pediatric Care for Oral Clefts - South America
Cleft lip and palate are a significant component of morbid human birth defects in the developing world. This study measures the impact of having a child born with a cleft lip on subsequent maternal/infant family health, and…
- Conditions
- Cleft Lip, Cleft Palate, Congenital Defects
- Trial name
- NCT00097149
- Testing
- Systematic pediatric care
- Where
- Brazil
- Volunteers
- 696 people
- Sponsor
- NICHD Global Network for Women's and Children's Health
Cleft Lip and Palate, Maxillary Hypoplasia
Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better?
Cleft lip and palate patients normally present with a sunken face due to collapse in the middle part of the face and inability of the upper and lower teeth to meet during chewing.
- Trial name
- NCT00930124
- Testing
- Orthognathic surgery, Distraction osteogenesis
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Class III Malocclusion, Maxillary Deficiency
Evaluation of Pain and Functional Impairments When Treating Class III Malocclusion Using Two Treatment Procedures
A clinical examination of each recalled candidate patient will be carried out at Adib Al Lahham Centre at the Ministry of Health Damascus to ensure that he/she meets the inclusion criteria.
- Trial name
- NCT06877780
- Testing
- RMR with SME, BAIMT with RME
- Where
- Syria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Damascus University
Pierre Robin Syndrome
Effect of Oral Enteral Nutrition in Pierre Robin Syndrome
This was a randomized controlled study. The infants enrolled were randomly divided into the IOE group (with Intermittent Oro-Esophageal Tube Feeding, n=25) and the PNG group (with Nasogastric Tube Feeding, n=23), all receiving…
- Trial name
- NCT06303973
- Testing
- IOE, PNG
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Muhammad
Cleft Palate, Plasma Rich in Growth Factors
Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate
Does the plasma-rich growth factor (PRGF) with primary cleft palate repair accelerate wound healing and prevent post-operative oronasal fistula occurrence?
- Trial name
- PRGF (NCT06889181)
- Testing
- Plasma Rich in Growth Factors (PRGF)
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Lip, Cleft Palate
Use of Titanium Plate in Rhinoplasty in Patients With Cleft Lip and Palate : Aesthetic and Functional Impact.
The patients in this study are all born with a cleft lip and palate. They underwent several interventions in childhood to take care of it.
- Trial name
- PETROL/TROPHIC (NCT03572907)
- Testing
- Rhinoplasty questionnaire
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Cleft Lip, Cleft Palate
Effects of AlignBabyCleft (ABaCleft)
Since the appearance of presurgical infant orthopedic (PSIO) as a treatment for patients with cleft lip and palate ( CLP) , numerous techniques have been described with the aim of aligning the displaced alveolar segments and…
- Trial name
- (ABaCleft) (NCT05357092)
- Testing
- Appliance. Orthodontic appliance to carry out dentoalveolar movement
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Cleft Palate
Furlow With Buccinator and Fistula Formation
Furlow with buccal myomucosal flap (group 1) Local anesthesia with a vasoconstrictor will be injected at the beginning of the surgery after Z- flap outline marking.
- Trial name
- NCT07840911
- Testing
- furlow with buccinator, two flap palatoplasty
- Volunteers
- 20 people
- Sponsor
- Fayoum University
Surgical Infants on NG/NJ/J/G-tube Feeds, Tracheoesophageal Fistula
A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months
This is the 5th in a series of physiological studies to determine the amino acid requirements of infants. There have been 4 studies to determine tyrosine, methionine, threonine and lysine requirements in infants when they are fed…
- Conditions
- Surgical Infants on NG/NJ/J/G-tube Feeds, Tracheoesophageal Fistula, Pierre-Robin Syndrome, Diaphragmatic Hernia
- Trial name
- INFORALTHR (NCT02364843)
- Testing
- Amino Acid: Threonine
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- The Hospital for Sick Children
Cleft Palate
An Investigation for the Optimal Timing of a Cleft Palate Repair
The effect of timing of cleft palate repair on speech development, velopharyngeal functioning, and facial growth remains unknown.
- Trial name
- NCT00779961
- Testing
- Palatoplasty
- Where
- Canada
- Volunteers
- 320 people
- Sponsor
- The Hospital for Sick Children
Palate, Cleft
Evaluation of Quality of Life After Orthognathic Surgery in a Cleft Lip and Palate Context
The purpose of this study is to compare, prospectively, the quality of life of patients with cleft lip and palate before and after orthognathic surgery.
- Trial name
- ORTHOQOL (NCT04049058)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Lille
Cleft Palate
Fistiulation Rate Following Primary Cleft Repair≤
Aim : The aim of present study was to evaluate the buccinator flap utilization in primary cleft palatoplasty on fistulation rate.
- Trial name
- NCT05166408
- Testing
- Buccinator myomucosal flap, Bardach two flap palatoplasty
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Malocclusion, Maxillary Deficiency
Effect on Periodontal Phenotype of Flapless Piezoincission During Orthodontic Treatment
Research Question While the reduction in treatment times and the patient satisfaction after periodontally accelerated osteogenic orthodontics (PAOO) are well sustained in the scientific literature, there is still controversy…
- Trial name
- Piezo_Ortho (NCT06315348)
- Testing
- flapless alveolar decortication with augmentation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Complutense de Madrid
Jaw Abnormalities
Prospective Registry of 3-dimensional Virtual Treatment Planning of Orthognathic Surgery
Orthognathic surgery or corrective jaw surgery is indicated for conditions of the jaw and face that are related to structure or growth malfunctioning, orthodontic problems, or co-morbidities associated with skeletal…
- Trial name
- 3D-VIRTOG (NCT02660021)
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- AZ Sint-Jan AV
Pierre Robin Sequence (PRS), Difficult Laryngoscopy
3D-CT-Based Prediction of Difficult Laryngoscopy in Infants With Pierre Robin Sequence
This study aims to develop and validate a quantitative prediction model using three-dimensional computed tomography (3D-CT) imaging for identifying infants with Pierre Robin sequence (PRS) at risk of difficult laryngoscopy.
- Conditions
- Pierre Robin Sequence (PRS), Difficult Laryngoscopy, Airway Management
- Trial name
- PRS-3DCT (NCT07257276)
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Nanjing Children's Hospital
Cleft Palate, Cleft Lip
Targeting Surgeons' Decision-Making for Cleft Lip Surgery
Using separate prospective cohorts of patients who have lip revision and lip repair surgery, the objective of this clinical trial is to both qualitatively and quantitatively assess how surgeons integrate the objective measures…
- Trial name
- NCT03537976
- Testing
- Static Images and Facial Videos
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Tufts University
Cleft Palate, Cleft Palate, Unilateral, Complete
MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate Repair
The goal of this case series study is to learn if magnetic resonance imaging (MRI) can show how well the palate and throat muscles work at rest and during speech after late cleft palate repair.
- Conditions
- Cleft Palate, Cleft Palate, Unilateral, Complete, Cleft Lip, Cleft Alveolus and Cleft Palate, Cleft Palate Repair
- Trial name
- NCT07514091
- Testing
- Modified Furlow Palatoplasty combined with buccinator myomucosal flap
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University