Clinical trials: Joint Contracture
Cerebral Palsy, Contracture
Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy
In this controlled dose-escalation study, we will study the initial safety, biological properties, and potential efficacy of 5-azacytidine (AZA).
- Trial name
- NCT06377085
- Testing
- 5-Azacytidine 10mg/m^2
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Shirley Ryan AbilityLab
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Dupuytren Contracture
BOND Study: the Benefit Of Night Splinting in Dupuytrens'
The BOND study is a prospective, randomised single blinded controlled trial to assess the effect of night splinting in patients who have had collagenase injection and manipulation therapy for Dupuytren's Contracture.
- Trial name
- BOND (NCT03031080)
- Testing
- Thermoplastic Hand Splint
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Brain Injuries, Disorder of Consciousness
Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness
The purpose of this study is to assess the effects on upper limb spasticity of soft splints worn during three weeks three hours a day by patients with stroke or disorders of consciousness.
- Conditions
- Brain Injuries, Disorder of Consciousness, Stroke, Spasticity as Sequela of Stroke
- Trial name
- NCT03008486
- Testing
- Real soft splint (6 cm)
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Géraldine Martens
Cerebral Palsy, Muscle Contracture
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contracture, Spasticity, Muscle
- Trial name
- CPMuscleSL (NCT05518565)
- Testing
- No intervention
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Eva Ponten
Hip Flexion Contractures
Hip Flexor Resistance Training on Pin Young Female Cricket Players
The aim of this research is to study the role of hip flexor strength in the act of particular movement tasks generally required in cricket.
- Trial name
- NCT04668053
- Testing
- Traditional training protocol, Hip flexor resistance protocol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Joint Contracture, Contracture
Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft
The purpose of this study is to compare how often joint contractures in the arms and legs come back after two common types of reconstructive surgery: Z-plasty and full-thickness skin graft (FTSG).
- Conditions
- Joint Contracture, Contracture, Cicatrix, Burn Scar Contractures
- Trial name
- NCT07885046
- Testing
- Z-Plasty, Full-Thickness Skin Graft
- Volunteers
- 300 people
- Sponsor
- Universitas Sebelas Maret
Contractures, Scars
Preexpanded Perforator Flaps in Children
Contractures and broad scars of the axilla, anterior chest wall and neck have detrimental effects on functional, physical and psychological development of children.
- Trial name
- NCT01700595
- Testing
- new technical intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 7 people
- Sponsor
- Istanbul University
Cerebral Palsy
A Comparative Study of the Effectiveness of Treatment of Contractures With Mechanically Applied Stretch and Heat.
This study is looking at new ways to stretch knee contractures in children with cerebral palsy using a specially designed splint.
- Trial name
- NCT00281359
- Testing
- With heat, No heat
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Disorder of Shoulder, Other Musculoskeletal Disorder
The Acute Effect of a Mobilization With Movement Technique to Improve Internal Rotation of the Shoulder
For many years researchers have been documented that the shoulder of the throwing athlete acquires a increase in external rotation of the dominant limb compared to the contralateral side.This fact is followed with a loss of the…
- Conditions
- Disorder of Shoulder, Other Musculoskeletal Disorder, Contracture
- Trial name
- NCT01639651
- Testing
- Posterior capsule stretching, Mobilization with movement
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Scar, Contracture
Perforator Artery Changes During Suprafascial Pre-expansion of the Perforator Flaps
Tissue expansion methods have been recommended as a means of improving the clinical results with perforator flaps but in plastic surgery literature there are few clinical trials supporting this opinion.
- Conditions
- Scar, Contracture, Flap Disorder
- Trial name
- NCT01777386
- Testing
- preexpanded perforator flap surgery
- Volunteers
- 14 people
- Sponsor
- Istanbul University
Internal Rotation Contracture-shoulder, Articulation Disorders
Internal Rotation Deficit of the Glenohumeral Joint in Advanced-level Handball Players
The main objective of this study is to estimate the incidence and prevalence of Internal Rotation Deficit (IRD) defined by a measure of IRD 2 (Internal Rotation Deficit in position 2) strictly greater than 20 ° in a population of…
- Conditions
- Internal Rotation Contracture-shoulder, Articulation Disorders, Athletic Injuries
- Trial name
- GIRDH (NCT02011243)
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Burn Joints, Joint Contractures
Effect of Paraffin Wax on Joint Contractures
Limited studies have objectively evaluated the benefit on skin pliability, and relieving itch and pain of paraffin wax, nor has paraffin wax treatment been compared to mineral oil, which is an ingredient in therapeutic paraffin…
- Trial name
- NCT07837687
- Testing
- Paraffin wax, Mineral oil
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Proximal Interphalangeal Finger Joint Contractures
High Doses of Total End Range Time Offer Better Results Than Low Doses Treating Proximal Interphalangeal Joint Stiffness
Elastic Tension Digital Neoprene Orthosis is a new device that can increase the dose of treatment of the proximal interphalangeal flexion contractures.
- Trial name
- NCT05625451
- Testing
- Elastic Tension Digital Neoprene Orthosis
- Where
- Spain
- Volunteers
- 91 people
- Sponsor
- Vicenç Punsola Izard
Cerebral Palsy
Early Intervention in Infants With Cerebral Palsy
Contractures are a frequent cause of reduced mobility in children with Cerebral palsy (CP) already at the age of 2-3 years. Reduced muscle use and muscle growth have been suggested as key factors in the development of…
- Trial name
- CONTRACT (NCT04250454)
- Testing
- CONTRACT
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Copenhagen
Osteoarthritis, Dislocations
Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data
Surgery is a common treatment type for damaged joints, tendons and nerves in the upper limb where conservative measures are inappropriate or have failed.
- Conditions
- Osteoarthritis, Dislocations, Inflammatory Arthritis, Rotator Cuff Tear
- Trial name
- NCT03573765
- Testing
- Shoulder arthroplasty, Elbow arthroplasty, Hand and wrist arthroplasty
- Volunteers
- 8,308,821 people
- Sponsor
- University of Oxford
Flexion Contracture of Proximal Interphalangeal Joint, Joint Deformities, Acquired
Rationale and Analysis of the Use of ETDNO in the Treatment of PIPJ Flexion Contracture:
Introduction: Flexion contracture is one of the most frequent complications in finger trauma. The use of orthoses to obtain the best total end range time (TERT) is the most popular method to treat this pathology .
- Trial name
- NCT05465603
- Testing
- ETDNO (Elastic Tension digital neoprene orthosis)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vicenç Punsola Izard
Contracture, Hand
Effects of Paraffin Wax Therapy vs METs in Post Burn Hand Contractures
The degree of the burn and the rate of scar development during healing are the main determinants of loss of hand function following thermal injury.
- Trial name
- NCT06198062
- Testing
- Paraffin wax bath therapy, Paraffin Wax Bath Therapy and Muscle Energy Techniques
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
H Syndrome
Histiocytosis and Inflammatory Manifestations in Patients with H Syndrome
H syndrome is a rare genetic disorder predisposing to histiocytosis. Our knowledge of the clinical spectrum of these patients is based on case reports and small patient series.
- Trial name
- NCT06742073
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center