Clinical trials: Joint Replacement
Infection of Total Hip Joint Prosthesis, Implants
Immunology of Failing Metal-on-Metal Hip Replacement
Metal-on-metal total hip replacement (MoM THR) has been targeted at younger patients with anticipated long-term survival since the bearing surfaces wear less than the traditional metal-on-plastic (MoP) replacements.
- Trial name
- NCT01517737
- Where
- 2 sites in United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
ARTHROPLASTY, REPLACEMENT
American Joint Replacement Registry
The American Joint Replacement Registry is a not-for-profit 501(c)(3) organization for data collection and quality improvement initiatives for total hip and knee replacements.
- Trial name
- AJRR (NCT01909375)
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- American Joint Replacement Registry
Knee Osteoarthritis, Knee Arthritis
Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty
Rehabilitation after Total Knee Arthroplasty surgery involves physical therapy services to address limitations in range of motion, strength, and participation in normal daily activities.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy
- Trial name
- NCT03302832
- Testing
- Physical Therapy, In-home Exercise Equipment
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Campbell University, Incorporated
Knee Osteoarthritis, Hip Osteoarthritis
Comparison of Knotless Barbed Suture and Standard Suture in Knee Replacement Patients
Barbed suture use has been gaining increased acceptance and has been reported to offer potential advantages in wound closure of hip and knee replacement surgeries.
- Trial name
- NCT03031314
- Testing
- barbed suture, standard suture
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Washington Hospital Healthcare System
Osteoarthritis
Feasibility Study: Effect of Patient Decision Aids for Total Joint Replacement on Surgical Referrals
Ministries of Health consider wait lists for total joint replacement a top priority. Research priorities to manage wait lists indicate the need to establish benchmarks that consider patient preferences.
- Trial name
- NCT00743951
- Testing
- 1 Patient decision aid, 2 Usual care
- Where
- Canada
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Pain, Spinal Surgeries, Hip and Knee Joint Replacement, Adverse Events
RAHM Foundation Retrospective Study of Various Diseases
This is a retrospective data collection on treatment of various disorders. This registry will include a variety of different products, implants, technologies and procedures.
- Trial name
- NCT02359786
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Rahm Foundation
Osteoarthritis, Hip
Change of Cognitive Performance Through Hip Replacement
The purpose of this study is to investigate the effectiveness of a hip arthroplasty for chronic pain, caused by a unilateral primary Coxartrhrose, regarding the cognitive performance.
- Trial name
- KogniTEP (NCT02997891)
- Testing
- everyday activity, cognitive performance
- Where
- 2 sites in Germany
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Osteoarthritis Knee
Comparison of an Old Versus a New Total Knee Replacement
A randomized controlled clinical and RSA study, comparing 2 knee implants: 1. NexGen CR cemented total knee arthroplasty 2. Persona CR cemented total knee arthroplasty 3 hospitals will participate in the study: Helse Bergen HF…
- Trial name
- NCT03548792
- Testing
- RSA radiostereometric analysis, Clinical comparison
- Where
- Norway
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Helse-Bergen HF
Osteoarthritis, Arthritis
Marathon and Enduron Polyethylene at Long-Term Follow-up
The purpose of the study is to determine whether crosslinked Marathon and standard Enduron polyethylene liners show differences in survivorship due to wear-related revisions at minimum 14-year follow-up and every 5 years after.
- Conditions
- Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02508428
- Testing
- Hip Replacement with crosslinked Marathon polyethylene, Hip Replacement with noncrosslinked Enduron polyethylene
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Anderson Orthopaedic Research Institute
Total Knee Arthroplasty, Total Knee Replacement
ALknee Follow-up Study of the Cementless ATTUNE Rotating Platform and the Cementless LCS Rotating Platform Knee System
The cementless ATTUNETM Rotating Platform Knee system was compared in a single-blind, randomized RSA trial to its predecessor, the LCS rotating platform Knee System.
- Conditions
- Total Knee Arthroplasty, Total Knee Replacement, Knee Osteoarthritis
- Trial name
- NCT05623215
- Testing
- Radiographs of the knee for radiostereometric analysis (RSA)
- Where
- Netherlands
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Spaarne Gasthuis
Knee Arthroplasty
The Efficiency of the PNF Method
Background: Early rehabilitation following knee arthroplasty is an integral part of medical management which reduces the time of patient's stay at hospital and eliminates the risk of post-operative complications.
- Trial name
- NCT04686071
- Testing
- PNF method, Standard rehabilitation
- Where
- 2 sites in Poland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Osteoarthritis, Knee
Postoperative Drainage in Total Knee Arthroplasty in the Presence of Tranexamic Acid
The investigator's aim with this study is to address, with the new paradigm of tranexamic acid, the role of wound drainage following total knee arthroplasty in blood loss, blood transfusion requirements and functional recovery
- Trial name
- NCT03915756
- Testing
- Drainage of surgical wound
- Where
- Portugal
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Beatriz Ângelo
Osteoarthritis, Knee
Outcomes After Standard and High-Flexion Posterior Stabilized Rotating-Platform Mobile-Bearing Total Knee Arthroplasty
The aim of this prospective study is to compare the clinical and radiographic outcomes of standard and high-flexion posterior stabilized (PS) rotating-platform mobile-bearing (RP-MB) total knee arthroplasty.
- Trial name
- NCT00954954
- Testing
- Standard PS RP-MB (P.F.C Sigma Rotating Platform knee), High-flexion PS RP-MB (P.F.C Sigma Rotating Platform Flex)
- Where
- South Korea
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Comparative Study of Total Knee Arthroplasty Using a Customized-patient Specific Instrument System.
Patient-specific instrumentation (PSI) has been introduced in total knee arthroplasty (TKA) as a new technology for improving accuracy in restoration of the alignment and biomechanics of the lower limb.
- Trial name
- NCT02500160
- Testing
- Patient specific instrumentation (MRI), Patient specific instrumentation (CT)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kyung Hee University Hospital at Gangdong
Arthritis
Fascial Manipulation® Associated With Standard Care Versus Standard Post-surgical Care for Total Hip Arthroplasty
Post-surgical physiotherapy programs following to total hip arthroplasty (THA) show important differences between types and numbers of treatment sessions.
- Trial name
- NCT02576028
- Testing
- Fascial Manipulation® (FM), standard active exercises
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Bolognini di Seriate Bergamo
Temporomandibular Joint
Tempromandibular Joint Reconstruction Via Computer-Assisted Surgery Simulation
This study was planned to evaluate the accuracy of virtual surgical planning and three-dimensional (3D) printed templates in reconstruction of temporomandibular joint (TMJ) with costochondral graft.
- Trial name
- NCT06811415
- Testing
- virtual temporomandibular joint reconstruction with costochondral graft
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Tanta University
Osteoarthritis
A Post-Market Retrospective Study on Revision Total Knee Arthroplasty Using Medacta GMK® Revision Prosthesis
This is a retrospective, single-site observational study, designed to assess the clinical outcomes and collect safety data of GMK Revision knee system used for primary or revision total knee arthroplasty at minimum two years…
- Trial name
- NCT02912351
- Testing
- Patient record review, Radiographs, and questionaires.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medacta USA