Clinical trials: Keratitis
Vernal Keratoconjunctivitis
Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis
The objective of this study is to compare the efficacy of two different dosing regimen of NOVA22007 (1mg/ml ciclosporin/cyclosporine) eye drops, emulsion versus placebo (vehicle of the formulation) administered four times a day…
- Trial name
- NCT01751126
- Testing
- NOVA22007 ''Ciclosporin''
- Where
- 46 sites in United States, Croatia and 9 more
- Volunteers
- 169 people
- Sponsor
- Santen SAS
Corneal Ulcer, Eye Infections, Bacterial
Steroids for Corneal Ulcers Trial
The purpose of this study is to determine whether adding topical steroids improves the outcomes of bacterial corneal ulcers, especially visual acuity.
- Trial name
- SCUT (NCT00324168)
- Testing
- Antibiotics, Topical corticosteroid
- Where
- 5 sites in United States, India
- Volunteers
- 500 people
- Sponsor
- Thomas M. Lietman
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial
The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis…
- Trial name
- PUTT (NCT06213649)
- Testing
- Polyhexamethylene biguanide (PHMB), Topical corticosteroid
- Where
- 22 sites in United States, Brazil and 2 more
- Volunteers
- 232 people
- Sponsor
- Jeremy Keenan, MD, MPH
Infectious Keratitis
Cross-linking as Treatment in Infectious Keratitis
To compare between SCXL and ACXL for treatment of infectious keratitis
- Trial name
- NCT04383431
- Testing
- PACK-CXL
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Sohag University
Acanthamoeba Keratitis, Artificial Intelligence
Acanthamoeba and Artificial Intelligence
Acanthamoeba keratitis, caused by the pathogen Acanthamoeba spp, is recognized worldwide as a severe ocular infection that can pose potential risks to vision.
- Trial name
- NCT06332703
- Volunteers
- 151 people
- Sponsor
- IRCCS Ospedale San Raffaele
Herpetic Keratitis
Topical Ganciclovir Versus Systemic Aciclovir in the Treatment of Herpetic Keratitis
Traditional antiviral treatments, including systemic acyclovir, have shown effectiveness in resolving keratitis but can also lead to complications, including ocular surface toxicity and the development of acyclovir-resistant…
- Trial name
- NCT06757907
- Testing
- Acyclovir 400 MG, Ganciclovir (GCV)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Corneal Ulcer
Village Integrated Eye Workers Trial
VIEW is a community-randomized trial designed to determine whether it is possible to prevent corneal ulcers on a large scale. The study compares the incidence of corneal ulceration between villages in which volunteers are trained…
- Trial name
- VIEW (NCT01969786)
- Testing
- Corneal ulcer prevention program
- Where
- Nepal
- Volunteers
- 223,671 people
- Sponsor
- University of California, San Francisco
Infective Keratitis
Infective Keratitis in Minia Governate
The purpose of the study is to determine the microbiological aetiology, epidemiological factors, and clinical profile and treatment outcomes of infective keratitis in Ophthalmology department, Minia University. Egypt
- Trial name
- NCT04894630
- Testing
- antimicrobial treatment
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Keratitis, Microbial Keratitis
Pattern of Microbial Keratitis in Assiut University Hospital
The aim of the study is to explore the epidemiology, including risk factors, causative microorganisms, complications and clinical outcomes of microbial keratitis among patients attending cornea clinic at Assiut University…
- Trial name
- NCT07316244
- Testing
- corneal scraping including direct smear, culture and sensitivity
- Volunteers
- 100 people
- Sponsor
- Assiut University
Fungal Keratitis
Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis
A Phase II, Multi-center, Randomized, Masked, Parallel-Control Study to Evaluate the Clinical Efficacy and Safety of IVIEW-1201 (1.0% PVP-Iodine) Gel Forming Ophthalmic Solution in the Treatment of Fungal Keratitis.
- Trial name
- NCT06463678
- Testing
- IVIEW-1201, NATACYN®
- Volunteers
- 60 people
- Sponsor
- IVIEW Therapeutics Inc.
Vaccinia
Evaluation and Treatment of Eye Complications of Vaccinia Vaccination
This study will evaluate patients with eye complications related to vaccination against smallpox to learn more about these conditions. Vaccinia vaccination has been used for more than 100 years for preventing smallpox.
- Trial name
- NCT00081835
- Testing
- NP-016 Vaccine Immune Globulin (IV-VIG)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Eye Institute (NEI)
Keratoconjunctivitis, Conjunctivitis
Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis
To investigate the long-term efficacy and safety of FK506 ophthalmic suspension in patients with vernal keratoconjunctivitis
- Trial name
- NCT00567918
- Testing
- FK506
- Where
- 8 sites in Japan
- Volunteers
- 52 people
- Sponsor
- Astellas Pharma Inc