Clinical trials: Ketones
Gastrointestinal Infections, Ketosis
Oral Glucose Intervention for Children With Gastroenteritis and Ketosis
Fasting ketoacidosis adds morbidity to children affected by gastrointestinal infections. The investigators investigate oral glucose gel for its effectiveness in rapidly reducing ketoacidosis and for improvements in oral hydration…
- Trial name
- NCT02729870
- Testing
- Oral Glucose Gel
- Sponsor
- University of Florida
Status Epilepticus
Exogenous Ketone Esters for Refractory Status Epileptics
This study aims to investigate the efficacy of add-on exogenous ketone esters for the treatment of children with refractory generalized convulsive status epilepticus
- Trial name
- EKERSE (NCT05674552)
- Testing
- Exogenous ketone ester
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Obesity & Overweight, Diabete Type 2
Traditional Chinese Medicine Fasting Therapy, Ketone Levels, and Metabolic Improvements
This is a retrospective study using existing medical records. The purpose is to learn how Traditional Chinese Medicine (TCM) fasting therapy affects metabolism.
- Conditions
- Obesity & Overweight, Diabete Type 2, Metabolic Syndrome
- Trial name
- NCT07840807
- Testing
- Traditional Chinese Medicine Fasting Therapy
- Where
- China
- Volunteers
- 1,149 people
- Sponsor
- The Seventh Affiliated Hospital of Sun Yat-sen University
ADPKD
Treat Autosomal Dominant Polycystic Kidney Disease With Oral Ketone Ester?
The investigators are running a study to see if a special drink, called a "ketone ester", can help people with a type of kidney disease named "Autosomal Dominant Polycystic Kidney Disease" or ADPKD for short.
- Trial name
- ADKETONE (NCT06100133)
- Testing
- Ketone ester
- Volunteers
- 20 people
- Sponsor
- Universitair Ziekenhuis Brussel
Fracture Mandible, Mandibular Fractures
Clinical Assessment of Computer-assisted PEEK Versus Conventional Titanium Plates on Mandibular Body Fractures
Two groups of patients with mandibular body fractures indicated for Open reduction internal fixation alone or in combination with fractures elsewhere in the mandible or midface.
- Trial name
- NCT03466190
- Testing
- Titanium plate fixation, Custom made PEEK plate fixation
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Peri-implant Mucositis, Oral Bacterial Infection
Bacterial Microbiota Characterization on Implant-supported PEEK and Titanium Provisional Abutments
The aim of this study is to determine the relative abundances of the different bacterial phyla and families in the microbiota present on the surface of PEEK implant-supported provisional abutments compared to titanium…
- Conditions
- Peri-implant Mucositis, Oral Bacterial Infection, Bacterial Resistance
- Trial name
- NCT03998865
- Testing
- Provisional abutment material
- Where
- Chile
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Michael Wendler Ernst
Concussion, Mild, Concussion, Severe
Ketone Supplementation in Adolescents Post-Concussion
Adolescent brains undergo rapid and significant changes in structural architecture and functional organization during development.
- Conditions
- Concussion, Mild, Concussion, Severe, Concussion, Brain, Concussive Injury
- Trial name
- NCT04079907
- Testing
- Ketone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Mandibular Body Fractures
Assessment Polyether Ether Ketone (PEEK) Custom Made Plates Versuscustom Made Titanium Plates in Treatment of Mandibular Body Fractures
The design of the custom made Plates is customized to meet the individual needs of each patient and surgeon. By selecting plate design features, surgeons can customize the plate to create a patient specific solution.
- Trial name
- NCT07729345
- Testing
- computer-assisted Polyether ether ketone (PEEK) custom made plates
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Patient Satisfaction
Patient Centered Outcomes and Marginal Bone Changes in CAD/CAM Metallic and (PEEK) Partial Denture Frameworks
To compare PEEK to metallic partial denture frameworks in restoring mandibular Kennedy class I regarding patient satisfaction.
- Trial name
- NCT05622448
- Testing
- RPD with PEEK framework, RPD with metallic framework
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cranium; Deformity
Synthetic Cranioplasty PEEK Versus UHMWP
The purpose of this study is to report the investigators experience with synthetic reconstruction of cranial defects using computer guided milled UHMWP, in terms of benefits and limitations both clinically and radiographically in…
- Trial name
- NCT05250024
- Testing
- UHMWP Cranioplasty, PEEK Cranioplasty
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Drug Resistant Epilepsy
Exogenous Ketone Esters for Drug Resistant Epilepsy
This study aims to investigate the efficacy of add-on exogenous ketone esters for treating children with drug-resistant epilepsy
- Trial name
- EKEDRE (NCT05670847)
- Testing
- Exogenous ketone ester
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Metabolic Ketoacidosis, Ketoacidemia
0.9% Saline Versus Balanced Solutions in Severe Diabetic Ketoacidosis
Severe diabetic ketoacidosis (DKA) is a potentially serious complication of diabetes mellitus. The treatment regimen is based on insulin and rehydration. The choice of rehydration solution is a question that remains open.
- Conditions
- Metabolic Ketoacidosis, Ketoacidemia, Acetonemia, Acetonuria
- Trial name
- NCT05808972
- Testing
- Sodium chloride 0.9% (SC), Ringer lactate (RL)
- Where
- Tunisia
- Volunteers
- 92 people
- Sponsor
- Tunis University
VLCAD Deficiency, Fatty Acid Oxidation Defects
Acute Nutritional Ketosis in VLCAD Deficiency
To test if a ketone-ester based drink can boost muscle mitochondrial function in vivo in patients with VLCADD in order to establish a rational basis for therapeutic use in this disorder.
- Trial name
- NCT03531554
- Testing
- ketone ester drink, exercise, muscle biopsy
- Where
- 2 sites in Netherlands
- Volunteers
- 5 people
- Sponsor
- University Medical Center Groningen
Hypoglycaemia
Point of Care Ketone Measurement in the Newborn
Low blood sugar levels are common in babies after birth. This may be normal as babies can use other sources of energy. However if a baby does not produce these fuels the brain can be starved of energy and be damaged.
- Trial name
- POCKET (NCT02341313)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Kathryn Beardsall
Retention
Effectiveness of PEEK Fixed Retainer
A randomized clinical trial is set out to compare the effectiveness of two types of fixed retainer (multistranded stainless steel and PEEK types) in maintaining the stability of lower anterior teeth with less failure rate.
- Trial name
- RCT (NCT05557136)
- Testing
- Multistranded stainless steel fixed retainer, Polyether-Ether-Ketone (PEEK) fixed retainer
- Where
- Iraq
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Esraa Salman Jasim
MELAS Syndrome, Mitochondrial Diseases
Ketones & Mitochondrial Heteroplasmy
The current study is a prospective evaluation of the ability of ketosis to shift mitochondrial DNA (mtDNA) heteroplasmy in subjects harboring a known mutation in their mtDNA at position 3243 (A>G).
- Trial name
- NCT01252979
- Testing
- Medium-Chain Triglycerides
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- The University of Texas Health Science Center, Houston
Denture, CAD/CAM
Effect of Certain Denture Disinfectants on Surface Topography, Microhardness and Dimensional Stability of CAD/CAM Milled Polymethyl Methacrylate and Polyether Ether Ketone Denture Base Materials
This study aims to evaluate and compare the influence of different denture cleansing methods using 1% sodium hypochlorite solution, 0.2% chlorhexidine solution and effervescent alkaline peroxide tablet solution -according to…
- Conditions
- Denture, CAD/CAM, Stability, PEEK
- Trial name
- NCT07672847
- Testing
- M0 group, M1 group : PMMA+ Sodium hypochlorite, M2 group: PMMA+ Chlorhexidine
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Menoufia University