Clinical trials: Kidney Failure,Chronic
Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism (SHPT)
A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Paricalcitol For Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Participants With Stage 5 Chronic Kidney Disease (CKD)
The main objective of this study is to evaluate the safety, efficacy and pharmacokinetics of paricalcitol oral solution in pediatric participants of ages 0 to 9 years with SHPT associated with stage 5 CKD receiving Peritoneal…
- Trial name
- NCT04064827
- Testing
- Paricalcitol
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 2 people
- Sponsor
- AbbVie
Secondary Hyperparathyroidism
A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis
Assess the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of etelcalcetide in the treatment of secondary hyperparathyroidism (SHPT) in pediatric participants between ≥ 2 to < 18 years of age, with chronic…
- Trial name
- NCT03969329
- Testing
- Etelcalcetide
- Where
- 23 sites in Belgium, Czechia and 10 more
- Volunteers
- 24 people
- Sponsor
- Amgen
Brain Injuries, Malaria
An MRI Ancillary Study of a Malaria Fever Investigation
This study will seek consent from parents of children enrolled in the Malaria FEVER study to obtain neuroimaging and 12-month neuropsychiatric outcomes data and kidney function on their child.
- Conditions
- Brain Injuries, Malaria, MRI Imaging, Neurocognitive Deficits
- Trial name
- MRIA (NCT05746819)
- Testing
- Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT study
- Where
- 2 sites in Malawi, Zambia
- Volunteers
- 181 people
- Sponsor
- University of Rochester
Chronic Kidney Disease
Improving Care for Patients With Chronic Kidney Disease Using EMRALD
This pragmatic cluster randomized controlled trial will test the impact of feedback and a toolkit aimed at improving the management of chronic kidney disease (CKD) in the primary care setting.
- Trial name
- NCT02274298
- Testing
- CKD feedback and tools
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Kidney Diseases
Validation, Implementation, and Cost-analysis of a Strategy for Personalized Diagnosis of Rare Kidney Diseases
Chronic kidney disease (CKD) affects about 10% of the world population, with high morbidity and mortality. Genetic kidney diseases are increasingly recognized across all age groups and represent over 20% of all the causes of CKD.
- Trial name
- NCT06324136
- Testing
- Implementation of the diagnostic algorithm
- Where
- 3 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Meyer Children's Hospital IRCCS
Kidney Transplantation in Highly Sensitized Patients
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
The goal of this clinical trial is to learn about the efficacy and safety of imlifidase in highly sensitized paediatric patients, 1-17 years old, with end stage renal disease (ESRD).
- Trial name
- DINKY (NCT05753930)
- Testing
- Imlifidase
- Where
- 6 sites in Finland, France and 3 more
- Volunteers
- 10 people
- Sponsor
- Hansa Biopharma AB
Chronic Kidney Diseases
Effects of Resistant Starch Diet on the Gut Microbiome in Chronic Kidney Disease
The investigators want to learn more about how to help people who have chronic kidney disease (CKD). This study will increase the investigators understanding of how diet affects factors that can slow the progression of kidney…
- Trial name
- NCT03356990
- Testing
- Resistant Starch
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Arkansas
Cardiovascular Outcome, Kalemia Control
Fiber Intake in an End Stage Renal Disease (ESRD) Population Followed Over 2 Years
Our research involves the detailed description of the content of the diet of x dialysis patients. For our purpose we used a newly developed "food frequency questionnaire".
- Conditions
- Cardiovascular Outcome, Kalemia Control, Lipid Profile
- Trial name
- NCT00874380
- Testing
- Increasing total fiber intake in patient's diet
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwell Health
Acute Kidney Injury, Chronic Kidney Disease
Long Term Impact of Pediatric Acute Renal Injury in Severe Sepsis
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS (NCT02372721)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Diabetes Mellitus, Type 2, End Stage Renal Disease
Drug Interaction Potential of Pro-Inflammatory Conditions
Pro-inflammatory cytokines, which are elevated in pro-inflammatory disease states (e.g., type II diabetes mellitus [T2DM], irritable bowel diseases [IBD], and end stage renal disease [ESRD]) have been shown to inhibit hepatic…
- Conditions
- Diabetes Mellitus, Type 2, End Stage Renal Disease, Irritable Bowel Syndrome
- Trial name
- DIPPIC (NCT07360938)
- Testing
- None (Observational)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Chronic Kidney Disease
Registry to Evaluate Maintenance Treatment With Venofer in Pediatric Patients With Chronic Kidney Disease
The current registry is being undertaken to assess the long-term (12 month) safety and tolerability of Venofer in the pediatric population with chronic kidney disease that requires intravenous iron maintenance therapy.
- Trial name
- NCT02492672
- Where
- 9 sites in United States
- Volunteers
- 50 people
- Sponsor
- American Regent, Inc.
Uremia, End Stage Renal Disease on Dialysis
Independent Effects of Visceral Adipose Volume and Density on Patient Survival in Peritoneal Dialysis
It was VAT volume predict patient outcome, while VAT density predicted baseline membrane function in PD patients and reflected peritoneal vascular density and local inflammation status.
- Trial name
- NCT07086430
- Volunteers
- 358 people
- Sponsor
- RenJi Hospital
Hyperphosphatemia, Chronic Kidney Disease, Receiving Dialysis
A Study of a Novel Iron-based Phosphate Binder AP301 in Patients With Hyperphosphatemia in the U.S. and China
The goal of this clinical trial is to learn if AP301 could work in the patients receiving maintenance dialysis with elevated blood phosphate.
- Conditions
- Hyperphosphatemia, Chronic Kidney Disease, Receiving Dialysis, ESRD (End-Stage Renal Disease), Dialysis
- Trial name
- RESPOND-2 (NCT06933472)
- Testing
- AP301, AP301 Low Dose
- Where
- 42 sites in United States, China
- Volunteers
- 264 people
- Sponsor
- Alebund Pharmaceuticals
Sickle Cell Disease, Kidney Injury
Acute Kidney Injury in Patients With Sickle Cell Disease
Patients with sickle cell disease may be at risk for acute kidney injury (AKI)during sickle cell crisis (pain or acute chest syndrome).
- Conditions
- Sickle Cell Disease, Kidney Injury, Kidney Diseases, Kidney Disease, Chronic
- Trial name
- NCT03105271
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Kidney Disease, Dialysis
Dose-finding Study of MCI-196
The Primary Objective of this study is to determine the initial starting doses of colestilan (MCI-196) in paediatric subjects with Chronic Kidney Disease Stage 5 on Dialysis and with Hyperphosphataemia.
- Conditions
- Chronic Kidney Disease, Dialysis, Hyperphosphatemia, Paediatric
- Trial name
- NCT01814904
- Testing
- colestilan-L, colestilan-M, colestilan-H
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Tanabe Pharma Corporation
Chronic Kidney Disease Stage 5 (Disorder)
Acupressure and Fistula Needle Insert Pain Management
Introduction: This study was conducted to determine the effectiveness of acupressure application on Hegu (LI4) point on the severity of acute pain caused by fistula needle in patients with brescia-cimino, snuff-box and…
- Trial name
- NCT05971134
- Testing
- Acupreesure applied
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Baskent University
Proteinuria, Chronic Kidney Diseases
Efficacy and Safety of Dapagliflozin in Children With Proteinuric Chronic Kidney Disease
We aim to investigate the antiproteinuric effect of adding Dapagliflozin to the standard of care in children with proteinuria.
- Trial name
- NCT04531397
- Testing
- ACEI treatment, Dapagliflozin+ACEI treatment
- Where
- China
- Sponsor
- Children's Hospital of Fudan University
Chronic Kidney Disease
Patient INformation About Options for Treatment - PINOT
This prospective observational study is designed to find out what treatment options new patients with chronic kidney disease learn about from their renal unit.
- Trial name
- PINOT (NCT01298115)
- Where
- Australia
- Volunteers
- 721 people
- Sponsor
- University of Sydney
Heart Failure
Renal Denervation in Chronic Heart Failure
Renal denervation can be carried out for heart failure
- Trial name
- REACH (NCT02146794)
- Testing
- Renal denervation
- Volunteers
- 7 people
- Sponsor
- Imperial College London
End-Stage Renal Disease
Morbidity, Mortality, Short and Long-term Survival of Hemodialysis End-stage Kidney Disease Patients in Central Tanzania
Background: In the last 2 decades, Tanzania made great improvements in the renal replacement therapy infrastructure and services.
- Trial name
- NCT03988491
- Where
- Tanzania
- Volunteers
- 10,000 people
- Sponsor
- Benjamin Mkapa Hospital