Clinical trials: Kidney Transplant; Complications
Malignancy, Transplant Complication
Epidemiology of Complications After Solid Organ Transplantation - EpCOT Study
Cancer remains a major cause of morbidity and mortality post solid organ transplantation. While mortality from the other leading causes of death post-transplantation (e.g.
- Conditions
- Malignancy, Transplant Complication, Cancer, Kidney Failure
- Trial name
- EpCOT (NCT02991105)
- Where
- 2 sites in United Kingdom
- Volunteers
- 85,410 people
- Sponsor
- University of Birmingham
Cardiovascular Diseases, Kidney Transplant; Complications
Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause…
- Trial name
- CRAFT-CTCA (NCT06234410)
- Testing
- Computed tomography coronary angiography (CTCA)
- Where
- 2 sites in United Kingdom
- Volunteers
- 332 people
- Sponsor
- University of Edinburgh
Transplant Complication, Kidney Transplant
"A Privacy-protecting Environment for Child Transplants Health Related and Genomic Data Integration in the European Reference Network"
Protect_Child_101 is an observational study to be performed in children that have undergone a liver or renal transplant. The aim of this study is to analyse small variations in the genetic material (DNA) of transplanted children.
- Conditions
- Transplant Complication, Kidney Transplant, Liver Transplant
- Trial name
- Protect_Child (NCT07194057)
- Testing
- Whole genome sequencing, Polygenic Risk Score Calculation, Methylome and episignatures
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 200 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Antibody-mediated Rejection, Kidney Transplant; Complications
Clazakizumab for Chronic and Active Antibody Mediated Rejection Post-Kidney Transplant
Antibody mediated rejection (ABMR) is a unique, significant and often severe form of allograft rejection. This single center, phase I/II, open label single-arm exploratory study focuses on enrolling ten patients with biopsy…
- Conditions
- Antibody-mediated Rejection, Kidney Transplant; Complications, Transplant Glomerulopathy, Transplant Glomerulopathy - Late Form
- Trial name
- NCT03380377
- Testing
- Clazakizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanley Jordan, MD
Kidney Failure, Chronic, End-Stage Renal Disease
Clazakizumab in Highly-HLA Sensitized Patients Awaiting Renal Transplant
Patients who have had a previous allograft failure represent a major problem for transplant centers as they are highly-human leukocyte antigen (HLA) sensitized and unlikely to receive another transplant without significant…
- Conditions
- Kidney Failure, Chronic, End-Stage Renal Disease, Transplant Glomerulopathy, Transplant;Failure,Kidney
- Trial name
- NCT03380962
- Testing
- Clazakizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanley Jordan, MD
End Stage Kidney Disease, Delayed Graft Function
Better Evidence for Selecting Transplant Fluids
End-stage kidney disease (ESKD) is a significant, expensive health problem. Kidney transplantation improves survival, quality of life, and is much cheaper than dialysis treatment for ESKD.
- Conditions
- End Stage Kidney Disease, Delayed Graft Function, Kidney Transplant; Complications
- Trial name
- BEST-Fluids (NCT03829488)
- Testing
- Plasma-Lyte 148 (approx. pH 7.4) IV Infusion, 0.9% SODIUM CHLORIDE 9g/L injection BP
- Where
- 18 sites in Australia, New Zealand
- Volunteers
- 808 people
- Sponsor
- The University of Queensland
Kidney Transplant; Complications, Delayed Graft Function
Study of the Correlation Between Donor CIRBP and Transplanted Kidney Function
Deceased donors and recipients who successfully completed kidney transplantation between 2016 and 2019 were included in this study.
- Trial name
- NCT06641622
- Testing
- Prediction of delayed graft function
- Where
- China
- Volunteers
- 207 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Arterial Hypertension, Kidney Transplant; Complications
StOPping Hypertension and imprOving Children's Lives After KidnEy TranSplantation
Cardiovascular (CV) disease is a major morbidity in children after kidney transplantation (KTx), limiting life expectancy and impairing graft function.
- Trial name
- SOPHOCLES (NCT06589947)
- Testing
- Intensified BP control, Standard Treatment
- Volunteers
- 170 people
- Sponsor
- Hannover Medical School
Stem Cell Transplant Complications, Acute Graft Versus Host Disease
Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study
This study aims to establish a cohort of 500 patients with hematological disease who undergoing allogeneic hematopoietic stem cell transplantation in the northwest region.
- Conditions
- Stem Cell Transplant Complications, Acute Graft Versus Host Disease, Acute Kidney Injury, Major Adverse Cardiac Events
- Trial name
- NCT06386445
- Testing
- Serum metabolomics sequencing
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Post-Transplant Infections, Post-Transplant Renal Insufficiency
Study of the Complications Associated With Certain Stem Cell Transplants
Background: The National Institutes of Health (NIH) performs up to 100 allogenic stem cell transplants (allo-HSCT) each year. Many studies already look at different problems that can follow a transplant.
- Conditions
- Post-Transplant Infections, Post-Transplant Renal Insufficiency, Post-Transplant Pulmonary Complications
- Trial name
- NCT01919099
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplant; Complications, Kidney Transplant Infection
Pediatric Kidney Transplantation, Ureteroneocystostomy Techniques
In this study the researchers want to retrospectively compare non-refluxing ureteroneocystostomy (UNC techniques to reflux UNC techniques in paediatric kidney recipients with regard to urinary tract infections and uteral…
- Conditions
- Kidney Transplant; Complications, Kidney Transplant Infection, Kidney Transplant Failure and Rejection
- Trial name
- TUIKIT (NCT05397821)
- Testing
- UNC technique
- Where
- Netherlands
- Volunteers
- 398 people
- Sponsor
- Radboud University Medical Center
Liver Transplant; Complications, Renal Complication of Procedure
Renal Outcomes Among Post Liver Transplantation Patients
To evaluate Renal outcomes among patients, post liver transplantation at Assiut university.
- Trial name
- NCT06123260
- Testing
- renal function tests
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Renal Transplant Rejection, Immune Repertoire
ALLoreactive T-Cell receptOr RePertoire in kidnEy tranSplantation
In this study, the investigators will establish a workflow to generate unique patterns of the donor-reactive T cell repertoire using mixed lymphocyte reactions to select alloreactive T cell clones prior to transplantation Tissue…
- Conditions
- Renal Transplant Rejection, Immune Repertoire, Transplant; Complication, Rejection, Alloreactivity
- Trial name
- ALL-T-COPIES (NCT03422224)
- Testing
- Mixed lymphocyte reaction
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
End Stage Renal Disease, Pediatric ALL
Pediatric Kidney Transplant
End-stage renal disease (ESRD) is a rare disease in children. Renal transplantation (RT) is the treatment of choice for ESRD in the pediatric population. In France, around 100 pediatric kidney transplants are performed each year.
- Conditions
- End Stage Renal Disease, Pediatric ALL, Kidney Transplant; Complications
- Trial name
- PeKiT (NCT05977387)
- Where
- 4 sites in France
- Volunteers
- 500 people
- Sponsor
- Imagine Institute
Non-Alcoholic Fatty Liver Disease, Renal Transplant Complication Pre-Existing Disease
Transient Elastograghy to Detect Non Alcoholic Fatty Liver Disease in Renal Transplantation Recipients.
a. Primary (main): The presence of non alcoholic fatty liver disease in post renal transplantation recipients by non invasive methods as transient elastograghy b-Secondary (subsidiary): to evaluate if transient elastograghy could…
- Trial name
- NCT05894993
- Testing
- transient elastograghy
- Volunteers
- 50 people
- Sponsor
- Amany Khaled Ali Ahmed
Kidney Transplant; Complications
Effects of Graft Vascular Dimensions on Surgical and Functional Outcomes of Living Donor Kidney Transplantation
1. Correlate the radiological and intraoperative measuring of the vascular dimensions, 2. Assess the effect of the vascular dimensions on the short-term surgical complications and 3.
- Trial name
- NCT05797389
- Volunteers
- 30 people
- Sponsor
- Assiut University
Transplantation Infection, Kidney Transplant; Complications
Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients
This is a pilot study designed to investigate the alterations in the gut microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic hematopoietic stem cells and mesenchymal stem cells…
- Conditions
- Transplantation Infection, Kidney Transplant; Complications, Stem Cell Transplant Complications, Liver Transplant; Complications
- Trial name
- NCT04281797
- Testing
- Intestinal microbiome new generation sequencing
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
Kidney Transplant; Complications, Liver Transplant; Complications
Medicine Adherence and Effects on Transplants With Pilloxa's Electronic Pillbox
Poor adherence to medication among patients with chronic diseases is a major problem. A patient group where the adherence to prescribed medications is extremely important are organ transplanted patients.
- Trial name
- NCT03848585
- Testing
- Pilloxa Pillbox, Non active Pilloxa Pillbox
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Pilloxa
Kidney Transplant; Complications, Immunosuppression
Efficacy of Single Dose Anti-thymocyte Globulin in the Modulation of T Lymphocytes in Kidney Transplantation
The use of polyclonal anti-T cell antibodies (ATG) has benefits in kidney transplantation, however, its use is associated mainly with hematological, infectious, and neoplastic complications.
- Trial name
- NCT04835948
- Testing
- single dose of Anti-thymocyte globulin
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children