Clinical trials: Knee Infection
Periprosthetic Knee Infection
Outcome After Revisions of Infected Knee Arthroplasties
A prospective multicenter cohort study on all types of revision knee arthroplasty procedures performed due to infection.
- Trial name
- RIKA (NCT04427943)
- Testing
- revision surgery
- Where
- 8 sites in Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Primary Osteoarthritis of Knee Nos
Rate of Infection After Using Antibiotic Loaded Cement and Regular Cement in Total Knee Arthroplasty
Our study will be a prospective study To compare between the rate of infection after using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.this will be at assiut university…
- Trial name
- NCT06117839
- Testing
- using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Septic Arthritis
Surgical Management of Knee Septic Arthritis
Surgical excisional debridement is the mainstay of management in septic arthritis with necessary decompression, lavage, debridement, and partial synovectomy. However, there has been considerable debate over the optimal modality.
- Trial name
- NCT04786379
- Testing
- Arthroscopic Irrigation and Debridement, Open Arthrotomy with irrigation and debridement
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Amputation of Knee
Comparative Study of Through Knee Amputation Versus Above Knee Amputation Regarding Infection Rate and Function
The aim of this study is to search and compare outcomes of through knee amputation (TKA) and above knee amputation (AKA) in terms of Technique ,wound healing ,infection rate , function and ambulation
- Trial name
- NCT06365203
- Testing
- Through knee amputation, Above knee Amputation
- Volunteers
- 60 people
- Sponsor
- Assiut University
Surgery, Cataract
Routine Surgical Procedures During COVID-19 Pandemic: a French Nationwide Cohort Study
Determine the consequences of COVID-19 pandemic on routine targeted surgeries. Five surgical procedures were considered : cataract surgery, hip and knee arthoplasties, coronary revascularisation by angioplasty and definitive…
- Conditions
- Surgery, Cataract, Hip Arthroplasty, Knee Arthroplasty
- Trial name
- NCT05197660
- Testing
- surgical procedures
- Where
- France
- Volunteers
- 2,000,000 people
- Sponsor
- EPI-PHARE
Total Hip Arthroplasty (THA), Antibiotic Prophylaxis
Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.
Prosthetic Joint Infection (PJI) is a significant issue in joint replacement surgeries, causing additional surgeries and substantial healthcare costs.
- Conditions
- Total Hip Arthroplasty (THA), Antibiotic Prophylaxis, Revision Arthroplasty, Total Knee Arthroplasty
- Trial name
- REVISE (NCT07053943)
- Where
- Netherlands
- Volunteers
- 70,000 people
- Sponsor
- JointResearch
Prosthesis-Related Infections, Hip Prosthesis Infection
Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy.
It is not known in the literature how much sonication affects the patient's treatment. Another important issue is that the place of this method in diagnosis is not clear.
- Conditions
- Prosthesis-Related Infections, Hip Prosthesis Infection, Joint Infection, Biofilm
- Trial name
- NCT04304885
- Testing
- Sonication method
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Bezmialem Vakif University
Osteoarthritis, Septic Arthritis
Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques
Making the diagnosis underlying a painful, swollen joint currently involves aspiration followed by numerous microbiological and biochemical laboratory tests.
- Conditions
- Osteoarthritis, Septic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT02565160
- Testing
- Intra-articular aspiration of Joint, Joint irrigation washout, Total Joint Arthroplasty
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Imperial College London
Joint Infection, Periprosthetic Left Knee Joint Infection
Microbiological Structure of Pathogens of Periprosthetic Infection of Large Joints in the Post-Covid Period
Background. Infection is the most common complication of complications after joint arthroplasty. During the COVID-19 pandemic increased used antibacterial drugs by adults, this could change the spectrum of infectious agents and…
- Trial name
- NCT06267287
- Testing
- Microbiological examination of the patient's biological material and determination of antibiotic resistance
- Where
- Russia
- Volunteers
- 342 people
- Sponsor
- Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
Implant Infection, Skeletal Sarcoma
Implant-Related Infections in Patients With Skeletal Sarcomas
The aim of this observational study is to gain knowledge on the microbial and immunological factors behind implant-related infections in patients with skeletal sarcoma.
- Conditions
- Implant Infection, Skeletal Sarcoma, Hip Arthritis, Prosthesis-Related Infections
- Trial name
- IRISSAR (NCT07264296)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Knee Arthropathy, Recurrence
Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System
This study is a prospectively and retrospectively enrolled, post-market, open-label, non-randomized, single institution evaluation of clinical outcomes of primary or revision knee surgery patients who meet the eligibility…
- Conditions
- Knee Arthropathy, Recurrence, Knee Infection
- Trial name
- Hinge (NCT06379321)
- Testing
- Triathlon Hinge Knee (THK) System
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Total Knee Arthroplasty, Reinfection
Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies
A single-center retrospective cohort study was conducted in the Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University.
- Conditions
- Total Knee Arthroplasty, Reinfection, Aseptic Loosening, Revision
- Trial name
- NCT07232771
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Direct Infection of Hip- and Knee Arthroplasty
Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study
Introduction: Periprosthetic joint infection (PJI) is a common cause for reoperation after knee and hip arthroplasty surgery. Debridement, antibiotics and implant retention (DAIR) is recommended in early infections (< 4 weeks)…
- Trial name
- DAIR (NCT02087020)
- Testing
- Debridement, antibiotics and implant retention
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Danderyd Hospital
Periprosthetic Joint Infection (PJI)
Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection.
- Trial name
- NCT05117671
- Testing
- data collection to classify infection status
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 1,554 people
- Sponsor
- University Hospital, Basel, Switzerland
Anterior Cruciate Ligament Injuries
Infection Rates Between Using of Vancomycin Versus Gentamycin in Primary ACLR
The purpose of the study is to compare the efficacy of Vancomycin versus Gentamycin , in reducing infection rates following Anterior Cruciate Ligament Reconstruction .
- Trial name
- ACLR (NCT06050785)
- Testing
- Vancomycin
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assiut University
Periprosthetic Knee Infection
One-stage Versus Two-stage Revision of the Infected Knee Arthroplasty
This study investigates functional outcome and safety after one-stage versus two-stage revision of the infected knee arthroplasty.
- Trial name
- NCT03435679
- Testing
- one-stage, two-stage
- Where
- 9 sites in Denmark
- Volunteers
- 97 people
- Sponsor
- Odense University Hospital
Prosthesis-related Infections, Staphylococcal Infections
Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty
The number of patients requiring joint replacement is increasing due to its success in restoring function and pain relief, and the growing population of the elderly.
- Trial name
- NCT00423982
- Testing
- Rifampin-combination therapy, Monotherapy
- Where
- 8 sites in Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Wound Infection
Compare Antimicrobial to Conventional Suture in Patients Receiving Primary Total Knee Replacement
Total knee replacement is now one of the most popular reconstructive procedures for the elderly people to regain their functional capacity and life quality.
- Trial name
- Vicryl-Plus (NCT02533492)
- Testing
- vicryl, Vicryl plus
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- Mel Shiuann-Sheng Lee
Septic Arthritis
Two-stage Arthroplasty for the Septic Arthritis of the Native Knee Joint
Septic arthritis (SA) of the native knee joint is rare but difficult to manage. Open or arthroscopic debridement is currently the most widely used approach.
- Trial name
- NCT05484284
- Testing
- two-stage primary total knee arthroplasty with low-dose antibiotics
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine