Clinical trials: Labor Complications
Extremely Low Gestational Age Newborn, Premature Infant
Oropharyngeal Administration of Colostrum to Extremely Low Gestational Age Newborns
Colostrum is rich in cytokines and other immune agents that may provide immunomodulatory protection against nosocomial infection in extremely premature infants.
- Trial name
- NCT01536093
- Testing
- oropharyngeal administration of own mother's colostrum, oropharyngeal administration of sterile water
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Music
Effects of Different Music Tempos on Feeding Outcomes in Preterm Infants
Background Newborns perceive the world through sound, and music therapy in the neonatal intensive care unit has been shown to have significant benefits in terms of heart rate, oxygen saturation, sucking/feeding capacity, and…
- Trial name
- NCT07506811
- Testing
- Music Therapy
- Where
- China
- Volunteers
- 284 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Small for Gestational Age at Delivery, Low Birth Weight
Effect of a Fortified Balanced Energy-Protein Supplement on Birth Outcome and Child Growth in Houndé District, Burkina Faso.
The 2016 WHO antenatal care guidelines stated that pregnant women in undernourished populations should receive fortified balanced energy-protein (BEP) supplements to reduce the risk of stillbirth and small-for-gestational-age…
- Conditions
- Small for Gestational Age at Delivery, Low Birth Weight, Prematurity, Infant Malnutrition
- Trial name
- MISAME-3 (NCT03533712)
- Testing
- Fortified balanced energy-protein (BEP) supplement, Fe and folic acid supplement
- Where
- Burkina Faso
- Volunteers
- 1,788 people, healthy volunteers welcome
- Sponsor
- University Ghent
Prematurity
Bridging the Docosahexaenoic Acid (DHA) Gap: The Effects of Omega-3 Fatty Acid Supplementation in Premature Infants
The purpose of this study is to understand if the "DHA gap" can be corrected by giving a daily dose of DHA oil to preterm babies. DHA is an essential omega-3 fatty acid, which means our body cannot make DHA.
- Trial name
- NCT01908907
- Testing
- DHA oil, (MCT) Control oil
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Prematurity, Feeding Behaviors
Effects of Environmental Comfort and Oral Motor Stimulation on Comfort and Oral Feeding Readiness in Preterm Infants
This study aims to evaluate the effects of short-term environmental comfort interventions and oral motor stimulation on comfort and oral feeding readiness in preterm infants.
- Trial name
- NCT07917871
- Testing
- Massage, White Noise, Oral Motor Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University
Neonatal Hypoglycemia, Prematurity
Late Preterm Corticosteroids and Neonatal Hypoglycemia
This is a prospective randomized controlled trial investigating the timing of betamethasone administration in late preterm infants in relation to delivery and impact on neonatal hypoglycemia.
- Trial name
- NCT04869709
- Testing
- Betamethasone Sodium Phosphate
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Infant, Newborn, Infant, Low Birth Weight
Early Blood Pressure Management in Extremely Premature Infants
This trial tests the feasibility of enrolling 60 extremely preterm infants in a randomized, double-blinded study of blood pressure management within 12 months.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- ELGAN BP (NCT00874393)
- Testing
- Dopamine, Hydrocortisone
- Where
- 17 sites in United States
- Volunteers
- 10 people
- Sponsor
- NICHD Neonatal Research Network
Respiratory Distress Syndrome, Infant, Premature
Feasibility of Use of the PATH bCPAP and Oxygen Blenders Device With Neonates in Uganda
In this mixed methods study, the investigators assessed feasibility of use of the PATH bCPAP kit on neonatal patients as well as the usability and acceptability of the device by healthcare workers.The study took place in a rural…
- Trial name
- NCT05462509
- Testing
- bCPAP with blenders
- Where
- Uganda
- Volunteers
- 14 people
- Sponsor
- PATH
Preterm, Parent-Child Relations
Sensory Optimization of the Hospital Environment
The long-term goal of this project is to improve the health and well-being of preterm infants and their parents. Although there is evidence to support positive multisensory interventions in the NICU, these interventions are often…
- Conditions
- Preterm, Parent-Child Relations, Parents, Development, Infant
- Trial name
- SOOTHE (NCT05230199)
- Testing
- SENSE multisensory program, Monitored standard of care
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- University of Southern California
Infantile Hemangioma, Very Low Birth Weight Infants
Timolol for the Prevention of Proliferation of Infantile Hemangioma (TiPPIH Trial)
The purpose of this trial is to see if a topical beta blocker is effective in preventing the proliferation of infantile hemangioma.
- Trial name
- TiPPIH (NCT01434849)
- Testing
- topical 0.5% Timolol maleate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Alice K. Gong
Premature Births
Long-term Effect of The Mother Infant Transaction Program (MITP)
The purpose of this study is to investigate if a cost and time effective intervention in a previous RCT for preterm infants and their parents can reduce the parents experience of concern and stress, and improve the childrens…
- Trial name
- 2007/2/0150 (NCT00903149)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Prematurity, Necrotizing Enterocolitis
Prediction of NEC With Urinary iFABP
During the first four days of life, intestinal fatty acid binding protein (iFABP) is elevated in the urine of premature babies who go on to develop necrotizing enterocolitis (NEC) days to weeks later.
- Trial name
- NCT01805206
- Testing
- Assessment of urinary iFABP, Administration of enteral feedings
- Where
- United States
- Sponsor
- Loma Linda University
Respiratory Distress Syndrome, Newborn, Endotracheal Intubation
An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.
This research focuses on one of the most common problems in newborn medicine: breathing difficulties. Breathing problems are the most common reason for admission to our neonatal unit at the National Maternity Hospital.
- Conditions
- Respiratory Distress Syndrome, Newborn, Endotracheal Intubation, Neonatal Intubation Performance, Prematurity
- Trial name
- NINJA (NCT06898801)
- Testing
- Just-in-time video training
- Where
- Ireland
- Volunteers
- 140 people
- Sponsor
- University College Dublin
Premature Birth, Antibiotics
NICU Antibiotics and Outcomes (NANO) Follow-up Study
The NANO follow-up study is designed to determine whether a simple, cost-effective intervention- withholding antibiotics at birth- reduces clinically relevant outcomes such as behavioral and neurological impairment at 2 years of…
- Conditions
- Premature Birth, Antibiotics, Neurodevelopment
- Trial name
- NANO-FU (NCT05977400)
- Testing
- Ampicillin, Gentamicin
- Where
- 15 sites in United States, Canada
- Volunteers
- 802 people
- Sponsor
- Sharp HealthCare
Uterine Atony, Postpartum Hemorrhage
An Evidence Based Protocol for Oxytocin Administration in Vaginal Delivery
The purpose of this study will be to evaluate a standardized, evidence-based protocol versus a conventional approach for the dosing of oxytocin in vaginal delivery.
- Trial name
- NCT02410655
- Testing
- Oxytocin
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Preterm Infant, Effect of Drugs
Zinc Supplementation In Very Low Birth Weight Infants-A Randomised Controlled Trial
Zinc (Zn) is a structural component of human body and is a crucial element for a wide variety of cascades that take place in almost all organ systems.
- Conditions
- Preterm Infant, Effect of Drugs, Zinc Deficiency Disease
- Trial name
- NCT05311540
- Testing
- Zinc Sulfate
- Where
- Turkey (Türkiye)
- Volunteers
- 195 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Premature, Neonatal Intensive Care Unit
The Effect of Gentle Human Touch and Stimulus Reduction on Pain and Comfort During Heel Blood Collection in Premature Newborns
Premature infants frequently experience painful procedures during their admission to neonatal intensive care units; this can lead to acute adverse events, imbalances, and long-term neurodevelopmental implications.
- Conditions
- Premature, Neonatal Intensive Care Unit, Touch, Nursing Care
- Trial name
- NCT07715682
- Testing
- Gentle Human Touch, Environmental Modification
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kubra Nur Kabakcı Sarıdağ
Preterm Birth
Clinical Grade MIS Device for Cervical Assessment to Predict Preterm Birth
Every year, globally, about 15 million babies are born preterm (before 37 weeks). This number is rising. Preterm birth (PTB) complications are the leading cause of death among children under 5 years of age, responsible for nearly…
- Trial name
- NCT04008485
- Testing
- Magnetic Electric Impedance Spectroscopy Device to predict PTB
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Infant, Newborn, Infant, Low Birth Weight
Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
This large randomized trial tested whether phenobarbital given to a pregnant woman about to deliver a premature infant would prevent brain injuries in their newborns.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Phenobarbital (NCT00009620)
- Testing
- Phenobarbital, Saline
- Where
- 11 sites in United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Ductus Arteriosus Patent, Respiratory Distress Syndrome
Paracetamol vs Ibuprofen for PDA Closure in Preterm Infants.
Current pharmacological options to treat an hemodynamically significant PDA (HsPDA) in preterm infants are limited to non-selective cyclo-oxygenase (COX) inhibitors, indomethacin or ibuprofen.
- Trial name
- PARIDA (NCT02056223)
- Testing
- Intravenous paracetamol, Intravenous ibuprofen
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Padova