Clinical trials: Labour Induction
Labor Induction, Cervical Ripening
Trial of Foley Catheter With and Without Extra-Amniotic Saline Infusion for Labor Induction
The purpose of this study is to compare the efficacy of a transcervical Foley catheter with and without extra-amniotic saline infusion (EASI) for priming the cervix for labor.
- Trial name
- FOLEYEASI (NCT00442663)
- Testing
- Transcervical Foley Catheter, Transcervical Foley Catheter with an EASI
- Where
- 4 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Labor Induction
A Randomized Trial of Two Regimens of Misoprostol for Second Trimester Termination for Intrauterine Fetal Death
Misoprostol (Cytotec®) is a synthetic prostaglandin E1 analog that has been marketed in the United States since 1988 as a gastric cytoprotective agent.
- Trial name
- NCT00141895
- Testing
- Misoprostol
- Where
- Lebanon
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Induction of Labor Affected Fetus / Newborn
Dexamethasone and Induction of Delivery
This study aims to evaluate the effect of intravenous injection of a single dose of dexamethasone in shortening the duration interval between initiation of labor induction and delivery of the fetus in primigravida full-term…
- Trial name
- NCT03658590
- Testing
- Dexamethasone, Distilled Water
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- samar sayed el sayed
Labor, Induced, Obesity
Misoprostol for Induction of Labor in Obese Women: Comparison Between 25 and 50 mcg Oral Administration
In recent decades, obesity has become a prevalent issue in Portugal, with 38.6% and 13.8% of the population being overweight or obese, respectively.
- Conditions
- Labor, Induced, Obesity, Pregnancy, Cesarean Section
- Trial name
- NCT05857059
- Testing
- Misoprostol 25 mcg, Misoprostol 50 mcg
- Where
- Portugal
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Failed Induction (of Labor) by Oxytocin
Continuous Oxytocin Infusion Versus Pulsatile Intravenous Oxytocin for Augmentation of First Stage of Labor
Comparing continuous intravenous oxytocin infusion with pulsatile administration of intravenous oxytocin for augmentation of the first stage of labor.
- Trial name
- NCT02723461
- Testing
- Pulsatile Oxytocin, Continuous Oxytocin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Labour; Induced, Pilot Study
High Volume Foleys Increasing Vaginal Birth Pilot Trial
It is currently unknown if there is a way to decrease the risk of cesarean delivery when undergoing cervical ripening and induction of labour.
- Conditions
- Labour; Induced, Pilot Study, Cervical Ripening
- Trial name
- NCT02993432
- Testing
- Foley catheter filled to 80cc, prostaglandin of the clinician's choice
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Bishop Score, Primigravida Women
Bishop Score vs. Cervical Length in Labor Induction
The study population consists of term primigravida women undergoing induction of labor at a tertiary care referral center in Assiut, Egypt.
- Conditions
- Bishop Score, Primigravida Women, Cervical Length
- Trial name
- NCT07208552
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Labor, Induced
Sublingual Misoprostol for Induction of Labor
The purpose of this study is to compare effectiveness and safety of a sublingual misoprostol 12,5 mcg with vaginal misoprostol 25 mcg for induction of labour with an alive and term fetus.
- Trial name
- SUBMISO (NCT01406392)
- Testing
- Misoprostol 25mcg, Sublingual Misoprostol
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Medical Induction of Labor Affecting Fetus
Titrated Oral Misoprostol Compared to Vaginal Dinoprostone for Induction of Labor
To test the safety and efficacy of titrated oral misoprostol compared to vaginal dinoprostone for labor induction.
- Trial name
- NCT02036437
- Testing
- Misotac® Sigma Pharmaceutical Industries, Dinoprostone 3 mg
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Induction of Labour, Labour, Induced
Misoprostol Labour Induction Study
Labour induction is a frequent obstetric intervention (~20%). Prostaglandins (PGs) are effective agents, but gastrointestinal (GI) intolerance has limited use to non-oral routes.
- Trial name
- NCT03489928
- Testing
- Oral Misoprostol, Vaginal Misoprostol, Dinoprostone
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- David Young
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Duration of Labor
Does Oral Propranolol Accelerate Labor Induction/Augmentation With Oxytocin in Nulliparous Women in Abakaliki?
Labour is usually physiologic, spontaneous and progressive, but occasionally, there may be the need for induction or augmentation of labour especially in nulliparous women, who are at increased risk of dysfunctional labour.
- Trial name
- NCT05251610
- Testing
- 20mg oral propranolol and oxytocin, Oxytocin only
- Where
- Nigeria
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Cervical Ripening
Comparison Between Vaginal and Sublingual Misoprostol 50 µg for Cervical Ripening Prior to Induction of Labor
To analyze whether there is a statistically significant difference in the modifications present in the uterine cervix 6 hours after administration of misoprostol 50 µg through vaginal versus sublingual routes.
- Trial name
- CMVS (NCT02732522)
- Testing
- Sublingual misoprostol, Vaginal misoprostol
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universidad de la Republica
Induction of Labor
Sublingual Versus Vaginal Misoprostol for Labor Induction at Term
Misoprostol (Cytotec®) is a synthetic prostaglandin E1 analog that has been marketed in the United States since 1988 as a gastric cytoprotective agent.
- Trial name
- NCT00140114
- Testing
- Misoprostol (Cytotec®)
- Where
- Lebanon
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Virtual Reality, Induction of Labor Affected Fetus / Newborn
VR Glasses During Induction of Labour for Pain and Anxiety Relieve
In the current study, The investigators aim is to test the distraction affect of "Virtual Reality" (VR) technology on pain and anxiety in pregnant women who undergo through an induction of labour with an extra-amniotic balloon…
- Conditions
- Virtual Reality, Induction of Labor Affected Fetus / Newborn, Extra Amniotic Balloon
- Trial name
- NCT05187247
- Testing
- Virtual Reality glasses
- Where
- Israel
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Obesity, Induction of Labor Affected Fetus / Newborn
Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term
Obesity increases the risk of pregnancy complications, including among others puerperal infections and cesarean delivery, and risk rises with increasing body mass index (BMI).
- Trial name
- APPOINT (NCT03801252)
- Testing
- Cefazolin, Azithromycin
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Pregnancy, Induction of Labor
Transcervical Foley Catheter With or Without Oxytocin for Induction of Labor
The purpose of the present study is to evaluate the possible benefit of concurrent IV Oxytocin infusion with trans cervical Foley catheter for pre-induction cervical ripening.
- Trial name
- NCT00684606
- Testing
- Oxytocin IV
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Intrauterine Fetal Demise, Fetal Death
Mifepristone Induction for Fetal Demise
Methods: Double blinded, randomized controlled trial with 1:1 allocation of mifepristone or placebo at initiation of induction of labor for fetal demise 20 weeks estimated gestational age or greater.
- Trial name
- MIFD (NCT02620904)
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Normal Vaginal Delivery
Oral Misoprostol Solution in Comparison to Vaginal Misoprostol in Induction of Labor
Induction of labour at term is a common obstetric intervention. Induction of labour is the artificial initiation of labour before its spontaneous onset for the purpose of delivery of the fetoplacental unit using mechanical or…
- Trial name
- NCT03863392
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University