Clinical trials: Laminectomy
Cervical Disc Prolapse
Functional Outcome After Combined Posterior Laminectomy and Anterior Cervical Discectomy and Fusion for Large Cervical Disc Prolapse
Cervical disc herniation (CDH) is the result of the displacement of the nucleus pulposus of the intervertebral disc, which may result in impingement of the traversing nerves as they exit the neural foramen or directly compressing…
- Trial name
- NCT06847503
- Volunteers
- 25 people
- Sponsor
- Assiut University
Ossification of the Posterior Longitudinal Ligament
A Prospective Study Comparing the Efficacy of Laminoplasty and Laminectomy With Fusion for Ossification of the Posterior Longitudinal Ligament With High Occupation Rate in Cervical Spine
The efficacy of laminoplasty and laminectomy with fusion for ossification of the posterior longitudinal ligament with high occupation rate in the cervical spine is not clear in the literature report so far.
- Trial name
- NCT05019001
- Testing
- Laminoplasty, Laminectomy With Fusion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Postoperative Pain, Postoperative Laminectomy Pain
Postoperative Analgesia in Laminectomy
Compare the analgesic effects of naproxen sodium codeine, paracetamol codeine and placebo on postoperative pain and tramadol (Contramal) consumption during the first 24 hour after a lumbar disk surgery.
- Trial name
- (PAL) (NCT02255955)
- Testing
- 550 mg naproxen sodium and 30mg codeine, 300 mg paracetamol and 30 mg codeine
- Volunteers
- 75 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Tethered Cord Syndrome
Efficacy and Safety of Nerve Root Axial Decompression Surgery in The Treatment of Tethered Cord Syndrome
Background: Tethered cord syndrome (TCS) is a progressive clinical condition including a series of neurological dysfunctions and deformities attributable to abnormally increased tension on the spinal cord, which is lacking…
- Trial name
- NCT03262844
- Testing
- Conservative treatment, Capsule surgery
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Changzheng Hospital
Failed Back Surgery Syndrome
Low Level Laser Therapy to Reduce Comorbidity in Spinal Surgery
Each year, more than one million individuals worldwide are submitted to laminectomies, with a failure rate higher than 40%. Postlaminectomy epidural adhesion is implicated as a main cause of ''failed back surgery syndrome'' and…
- Trial name
- LASPINE (NCT02529657)
- Testing
- Low Level Laser Therapy
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Tumor of Spinal Cord
Establishment and Application of Early Postoperative Activity Plan for Patients After Hemi-laminectomy for Lumbar Spinal Tumor Resection
Objective to construct the related early activity program for patients with lumbar intraspinal tumor after hemilaminectomy, and evaluate the postoperative limb function exercise according to the content of the program.
- Trial name
- NCT04968730
- Testing
- Postoperative rehabilitation nursing
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Achondroplasia
A Clinical Trial to Evaluate Safety of Vosoritide in At-risk Infants With Achondroplasia
Study 111-209 is a Phase 2 randomized, open-label clinical trial of BMN 111 in infants and young children with a diagnosis of Achondroplasia at a heightened risk of requiring cervicomedullary decompression surgery
- Trial name
- NCT04554940
- Testing
- vosoritide
- Where
- 3 sites in Australia, United Kingdom
- Volunteers
- 20 people
- Sponsor
- BioMarin Pharmaceutical
Chiari Malformation Type I, Tonsillectomy
PFDD Versus PFDRT in Chiari Decompression Surgery
The purpose of this study is to determine whether a posterior fossa decompression and duraplasty with or without tonsil manipulation results in better patient outcomes with fewer complications and improved quality of life in…
- Trial name
- NCT06079125
- Testing
- Posterior fossa decompression with duraplasty, PFDD with tonsillar resection/reduction
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xuanwu Hospital, Beijing
Cervical Spinal Cord Injury
Laminectomy Alone Versus Laminectomy and Fusion for Traumatic Cervical Spinal Cord Injury Without Instability
The aim of study is to compare clinical and radiological outcomes of laminectomy alone to laminectomy and fusion in the treatment of traumatic cervical spinal cord injury without instability.
- Trial name
- NCT05360524
- Testing
- Laminectomy alone versus laminectomy and fusion
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Assiut University
Surgical Site Infection, Antibiotics Prophylaxis
Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery
BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay.
- Trial name
- NCT05398081
- Testing
- Cefuroxime (Zinnat®), Ceftriaxone (Rocephin®)
- Where
- Nigeria
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Dr. Promise Tamunoipiriala Jaja
Cervical Spondylotic Myelopathy
Assessment of Surgical Techniques for Treating Cervical Spondylotic Myelopathy
The primary purpose of this study is to compare anterior and posterior surgical approach in treatment of CSM in terms of surgical complications and neurological, functional, disease-specific and quality of life outcomes measures.
- Trial name
- CSM (NCT00285337)
- Testing
- Laminectomy and Laminoplasty
- Where
- 13 sites in United States, Canada
- Volunteers
- 321 people, healthy volunteers welcome
- Sponsor
- AOSpine North America Research Network
Spinal Cord Injuries
Epidural Decompression Surgery Within 24 Hours After Acute Spinal Cord Injury Improves Spinal Nerve Function
To compare the effects of early (within 24 hours) and delayed (exceed 24 hours) epidural decompression surgery on the recovery of spinal nerve function in patients with acute spinal cord injury (complete and incomplete) at…
- Trial name
- NCT03103516
- Testing
- early epidural decompression group, delayed epidural decompression group
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital